Idiopathic basal ganglia calcification (Fahr's disease) and dementia

Nunomura, Akihiko

doi:10.1111/pcn.12378

Cited by 6 publications

(7 citation statements)

References 8 publications

(17 reference statements)

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“…Nunomura 6 wrote a recent editorial in this journal regarding some of the issues we highlighted here. Hence, we strongly suggest that all patients diagnosed with or suspected of having DNTC need to be screened for mutations linked to PFBC.…”

Section: 5mentioning

confidence: 99%

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Response to ‘Challenging the concept of diffuse neurofibrillary tangles with calcification (Kosaka–Shibayama disease)’

Kosaka¹

2016

Psychiatry Clin Neurosci

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Section: 5mentioning

confidence: 99%

“…Only with genetic studies we can ensure that DNTC is really a new entity and not a phenotype of PFBC. 6 …”

Section: 5mentioning

confidence: 99%

Response to ‘Challenging the concept of diffuse neurofibrillary tangles with calcification (Kosaka–Shibayama disease)’

Kosaka¹

2016

Psychiatry Clin Neurosci

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“…By 2030 cancer is predicted that because of the demographic changes alone, the number of recent cancer cases can increase by seventieth worldwide [3]. Experimental tumors have nice importance for the needs of modeling, and one among the most typical is that the bacteriologist pathology tumor, that springs from a spontaneous murine exocrine gland carcinoma [4]. Mutation studies have reported that chronic aerobic stress, especially from chronic inflammation, is related to carcinogenesis [5].…”

Section: Introductionmentioning

confidence: 99%

Role of Sulforaphane on Histone Deacetylase Activity in Solid Ehrlich Carcinoma

El-Keey¹,

Ibrahim²,

El-Ghonamy³

et al. 2020

JBM

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Histone acylation is one in every of the posttranslational modification that incorporates a role within the regulation of sequence expression. This study was aimed to ameliorate neoplasm cell model Solid Ehrlich malignant neoplastic disease with sulforaphane extracted from cabbage alone and together with immune suppressant drug (MTX) by study the activity of simple protein deacetylase accelerator (HDAC). In this study, sulforaphane was extracted from cabbage leaves and evaluated victimization GC-MS and ultraviolet illumination spectrophotometry. 60 white male rats were divided into six equal groups. Group I: management ordinarily. The remaining mice were subjected to Ehrlich neoplasm cells. Group II: Tumor-bearing group. Group III: immune suppressant drug "MTX" treated group. Group IV, V treated with SFN before and when Paul Ehrlich cells implantation group VI (Methotrexate and sulforaphane-treated group). This result showed that sulforaphane was extracted from cabbage (Brassica oleracea) in concentration of 833 µg/g leave. HDAC was attenuated when treatment with sulforaphane after treatment with methotrexate or sulforaphane alone. The desoxyribonucleic acid injury was attenuated in neoplasm tissue of tumor-bearing mice when treatment with immune suppressant drug and hyperbolic considerably in tumor tissue of tumor-bearing mice treated with sulforaphane before and after carcinogenesis and together with methotrexate treatment after carcinogenesis.

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“…Fahr's disease patients usually present with slow progressive cognitive impairment, psychiatric disturbance, or behavioral dysfunction. [2] However, some acute deterioration of Fahr's disease has gained more attention in recent years, including subarachnoid hemorrhage, aneurysmal subarachnoid hemorrhage and epileptic syncope. Here we describe a patient with acute sensory disability and both thalamic hemorrhage and idiopathic basal ganglia calcification was demonstrated in CT scanning.…”

Section: Introductionmentioning

confidence: 99%

Fahr’s disease presenting with thalamic hemorrhage: a case report

Wang

Cheng

et al. 2019

Preprint

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Background: Fahr’s disease is a rare neurological disorder which is characterized by diffuse intracranial calcification documented in bilateral basal ganglia and dentate nuclei of the cerebellum. In recent years, some acute presentations of Fahr’s disease have been reported. Here we describe a Fahr’s disease patient presenting with thalamic hemorrhage, which has not been reported so far. Case presentation: A 51-year-old man doesn’t have any prior premonitory symptoms and significant family history of neurologic disorder, he presented to our emergency department because of acute left limb numbness. Both brain CT and MRI study exhibited symmetric calcifications in bilateral basal ganglia and bilateral cerebellar dentate nuclei, which was consistent with Fahr’s disease. In addition, the blood investigation provided no criteria to secondary intracranial calcification. After proper clinical medical treatment and sustained physical rehabilitation, the patient’s symptoms relieved and he was discharged from hospital. Conclusion: We describe a case of sporadic Fahr’s disease presenting with thalamic hemorrhage. It is unknown whether the calcification in Fahr’s disease negatively affects intracranial vessels predisposing acute presentation. Therefore, the association between idiopathic basal ganglia calcification and acute cerebrovascular disease is worth special attention and needs further studies. Keywords: Fahr’s disease, thalamic hemorrhage.

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Idiopathic basal ganglia calcification (Fahr's disease) and dementia

Cited by 6 publications

References 8 publications

Response to ‘Challenging the concept of diffuse neurofibrillary tangles with calcification (Kosaka–Shibayama disease)’

Response to ‘Challenging the concept of diffuse neurofibrillary tangles with calcification (Kosaka–Shibayama disease)’

Role of Sulforaphane on Histone Deacetylase Activity in Solid Ehrlich Carcinoma

Fahr’s disease presenting with thalamic hemorrhage: a case report

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