Response to ‘<scp>C</scp>hallenging the concept of diffuse neurofibrillary tangles with calcification (<scp>K</scp>osaka–<scp>S</scp>hibayama disease)’

Kosaka, Kenji

doi:10.1111/pcn.12471

Cited by 2 publications

(1 citation statement)

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“…3 It has since been known as Kosaka-Shibayama disease. More recently, this entity has been controversially discussed, 4,5 although all cases occurring in Japan were thoroughly reviewed, 6 and similar cases were also reported outside Japan. 7 We here report a case associated with localized senile plaque calcification, which is not a feature of DNTC.…”

Section: Introductionmentioning

confidence: 99%

Senile plaque calcification of the lamina circumvoluta medullaris in Alzheimer's disease

et al. 2021

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Vascular calcification is a common phenomenon in the elderly, predominantly appearing in the basal ganglia and in the lamina circumvoluta medullaris of the hippocampus. Calcifications are not an inherent feature of Alzheimer's disease. On the other hand, a rare presenile type of dementia with symmetrical Fahr‐type calcifications and numerous neurofibrillary tangles without senile plaques has been described by Kosaka in 1994 and was termed “diffuse neurofibrillary tangles with calcification” (DNTC). We here report a case of Alzheimer's disease with calcifications both in the basal ganglia and in the lamina circumvoluta medullaris of the hippocampus, differing from DNTC by the presence of senile plaques. The calcifications in the hippocampus were not only vascular in nature but also covered amyloid‐β‐ and phosphorylated tau‐positive plaque‐like structures that were linearly arranged along the dentate fascia in the CA1 sector, an unusual finding of pathogenetic interest.

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Section: Introductionmentioning

confidence: 99%

Senile plaque calcification of the lamina circumvoluta medullaris in Alzheimer's disease

et al. 2021

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Tau in Tauopathies That Leads to Cognitive Disorders and in Cancer

Huda¹,

Pan²

2019

Cognitive Disorders

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Tau is a copious microtubule-associated protein mainly expressed in neurons; it is also expressed in non-neuronal cells. Tauopathies are neurodegenerative diseases occurring mostly within the neuronal and glial cells of the central nervous system with a conspicuous tau pathology. In tauopathies, soluble tau disconnects from microtubules and forms abnormal, aggregated filamentous assemblies of hyperphosphorylated tau. Genetic, pathological and biochemical analyses have also proved that tau protein plays a major role in the pathogenesis of several tauopathies. Cognitive disorders are a type of psychological disorders that mainly distress observation, learning, memory, and problem elucidating. Among different cognitive disorders like amnesia, dementia, and delirium tauopathies mainly involve in dementia. Though tau is a neuronal protein, it is also expressed in various non-neuronal cells, like those of the liver, kidney and muscle. The activity of non-neuronal tau, especially in cancer cells, still needs to be elucidated; tau might have significant functions in nonneuronal cells. This chapter describes the associations between tauopathies and cancer.

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Response to ‘Challenging the concept of diffuse neurofibrillary tangles with calcification (Kosaka–Shibayama disease)’

Cited by 2 publications

References 1 publication

Senile plaque calcification of the lamina circumvoluta medullaris in Alzheimer's disease

Senile plaque calcification of the lamina circumvoluta medullaris in Alzheimer's disease

Tau in Tauopathies That Leads to Cognitive Disorders and in Cancer

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