Identifying the preferred interaction mode of naringin with gold nanoparticles through experimental, DFT and TDDFT techniques: insights into their sensing and biological applications

Singh, Baljinder; Rani, Monika; Singh, Janpreet; Moudgil, Lovika; Sharma, Prateek; Kumar, Sanjeev; Saini, G. S. S.; Tripathi, S. K.; Singh, Gurinder; Kaura, Aman

doi:10.1039/c6ra12076h

Cited by 23 publications

(8 citation statements)

References 40 publications

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“…Naringin-conjugated gold nanoparticles (N-AuNPs) were evaluated with cytotoxicity and hemolysis assays, which showed their biocompatibility with MDA-MB-231 cell lines and normal red blood cells, while also demonstrating their potential to induce cell death in T47D, PC-3, and MCF-7 cell lines. In vivo studies must be conducted to confirm the active targeted delivery of N-AuNPs in cancer ( Singh et al, 2016 ).…”

Section: Nanostructered Formulations Of Naringin In Combating Malignanciesmentioning

confidence: 99%

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

et al. 2021

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Background: Natural product-based cancer preventive and therapeutic entities, such as flavonoids and their derivatives, are shown to have a noticeable capability to suppress tumor formation and cancer cell growth. Naringin, a natural flavanone glycoside present in various plant species, has been indicated to modulate different signaling pathways and interact with numerous cell signaling molecules, which allows for an extensive variety of pharmacological actions, such as amelioration of inflammation, oxidative stress, metabolic syndromes, bone disorders, and cancer. The purpose of this systematic review is to present a critical and comprehensive assessment of the antitumor ability of naringin and associated molecular targets in various cancers.Methods: Studies were identified through systematic searches of Science Direct, PubMed, and Scopus as well as eligibility checks according to predefined selection criteria.Results: Eighty-seven studies were included in this systematic review. There was strong evidence for the association between treatment with naringin alone, or combined with other drugs and antitumor activity. Additionally, studies showed that naringin-metal complexes have greater anticancer effects compared to free naringin. It has been demonstrated that naringin employs multitargeted mechanisms to hamper cancer initiation, promotion, and progression through modulation of several dysregulated signaling cascades implicated in cell proliferation, autophagy, apoptosis, inflammation, angiogenesis, metastasis, and invasion.Conclusion: The results of our work show that naringin is a promising candidate for cancer prevention and treatment, and might offer substantial support for the clinical application of this phytocompound in the future. Nevertheless, further preclinical and clinical studies as well as drug delivery approaches are needed for designing novel formulations of naringin to realize the full potential of this flavonoid in cancer prevention and intervention.

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Section: Nanostructered Formulations Of Naringin In Combating Malignanciesmentioning

confidence: 99%

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

et al. 2021

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“…The possible reason behind this differential response pattern of breast tumour cells lies in their heterogeneous molecular and functional characteristics and metabolic phenotypes. MCF-7 (oestrogen/progesterone receptor positive) and T47D (oestrogen/progesterone/androgen receptor positive) cell lines are non-invasive, oestrogen-dependent, hormone-responsive breast cancer cell lines, whereas MDA-MB-231 [oestrogen/progesterone/human epidermal growth factor receptor (HER-2) negative] is a triple-negative, highly invasive, oestrogen-independent, hormone-insensitive, late-stage breast cancer cell line 19 .…”

Section: Discussionmentioning

confidence: 99%

S961, a biosynthetic insulin receptor antagonist, downregulates insulin receptor expression & suppresses the growth of breast cancer cells

Sharma¹,

Kumar²

2018

Indian J Med Res

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Background & objectives:Insulin resistance associated with hyperinsulinaemia and overexpression of insulin receptors (IRs) have been intricately linked to the pathogenesis and treatment outcomes of the breast carcinoma. Studies have revealed that upregulated expression of IRs in breast cancer pathogenesis regulates several aspects of the malignant phenotype, including cell proliferation and metastasis. This study was aimed to investigate the pivotal role of an IR antagonist S961 on IR signalling and other biological parameters in MCF-7, MDA-MB-231 and T47D cell lines.Methods:The effect of human insulin and S961 on growth, proliferation rate and clonogenic potential of breast cancer cells was evaluated by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide] assay and clonogenic assay. The mRNA expression of IR isoforms (IR-A and IR-B) was measured in the breast carcinoma cells using quantitative PCR.Results:The study revealed that breast cancer cells predominantly expressed IR-A isoform and showed extensive growth and proliferation owing to IR overexpression. It was found that S961 downregulated the IRs (IR-A and IR-B) with nanomolar dose and efficiently blocked expression of IRs even in the presence of insulin. IR mRNA expression levels were significantly downregulated in the continued presence of S961. S961 also inhibited cellular proliferation and colony formation in breast tumour cells.Interpretation & conclusions:IR antagonist, S961 showed distinct antagonism in vitro and appeared to be a powerful therapeutic modality that might provide insight into the pathogenesis of impaired IR signalling.

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“…Later, this mixture was incubated for 3 hours, followed by centrifugation, and the absorbance was calculated by ultraviolet spectrometer using the general formula: % Hemolysis = ( A s − A n )/( A p − A n ) × 100%, where, A s , A n , and A p are the absorbance of the sample, the negative control, and the positive control, respectively. 50 - 53 …”

Section: Methodsmentioning

confidence: 99%

Lactoferrin-Loaded PEG/PLA Block Copolymer Targeted With Anti-Transferrin Receptor Antibodies for Alzheimer Disease

Xiang-hong

Wan

et al. 2020

Dose-Response

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Last few years, struggles have been reported to develop the nanovesicles for drug delivery via the brain–blood barrier (BBB). Novel drugs, for instance, iAβ5, are efficient to inhibit the aggregates connected to the treatment of Alzheimer disease and are being evaluated, but most of the reports reflect some drawbacks of the drugs to reach the brain in preferred concentrations owing to the less BBB penetrability of the surface dimensions. In this report, we designed and developed a new approach to enhance the transport of drug via BBB, constructed with lactoferrin (Lf)-coated polyethylene glycol-polylactide nanoparticles (Lf-PPN) with superficial monoclonal antibody-functionalized antitransferrin receptor and anti-Aβ to deliver the iAβ5 hooked on the brain. The porcine brain capillary endothelial cells were utilized as BBB typically to examine the framework efficacy and toxicity. The cellular uptake of the immuno-nanoparticles with measured conveyance of the iAβ5 peptide was significantly enhanced and associated with Lf-PPN without monoclonal antibody functionalizations.

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Identifying the preferred interaction mode of naringin with gold nanoparticles through experimental, DFT and TDDFT techniques: insights into their sensing and biological applications

Abstract: In this work, the binding behaviour of naringin – a flavonoid with AuNPs is explained by combining experimental and theoretical approaches.

Cited by 23 publications

References 40 publications

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

S961, a biosynthetic insulin receptor antagonist, downregulates insulin receptor expression & suppresses the growth of breast cancer cells

Lactoferrin-Loaded PEG/PLA Block Copolymer Targeted With Anti-Transferrin Receptor Antibodies for Alzheimer Disease

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