Identifying the association between contrast enhancement pattern, surgical resection, and prognosis in anaplastic glioma patients

Wang, Yinyan; Wang, Kai; Wang, Jiangfei; Li, Shaowu; Ma, Jun; Dai, Jianping; Jiang, Tao

doi:10.1007/s00234-016-1640-y

Cited by 17 publications

(17 citation statements)

References 30 publications

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“…Moreover, we found that the OS after surgery was 48.4 months for all anaplastic gliomas and 21.5 months in the AAw subgroup (Table 2). Previously reported prognostic factors for anaplastic glioma include advanced patient age, preoperative neurological status, KPS, symptom duration, tumor location, EOR, adjuvant therapy (including radiation therapy and chemotherapy), preoperative MRI findings, as well as various molecular markers including IDH and PTEN mutations, 1p/19q codeletion, epidermal growth factor receptor (EGFR) amplifica-tion, and MGMT methylation [4,[7][8][9][12][13][14][15]. The importance of these molecular markers for prognosis was reflected in the new WHO classification of 2016, which has had a great impact on the diagnostic criteria.…”

Section: Discussionmentioning

confidence: 99%

“…We performed volumetric analysis in the present study, confined to anaplastic gliomas, which have heterogenous features in MRI. A considerable proportion of anaplastic gliomas do not show contrast enhancement in T1weighted MRI [15,17]. Therefore, to obtain a more accurate tumor volume, both abnormal T2/FLAIR hyperintense lesions as well as T1-weighted contrast-enhanced lesions should be considered.…”

Section: Discussionmentioning

confidence: 99%

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Survival, Prognostic Factors, and Volumetric Analysis of Extent of Resection for Anaplastic Gliomas

et al. 2020

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The aim of this study is to evaluate the survival rate and prognostic factors of anaplastic gliomas according to the 2016 World Health Organization classification, including extent of resection (EOR) as measured by contrast-enhanced T1-weighted magnetic resonance imaging (MRI) and the T2-weighted MRI. Materials and Methods The records of 113 patients with anaplastic glioma who were newly diagnosed at our institute between 2000 and 2013 were retrospectively reviewed. There were 62 cases (54.9%) of anaplastic astrocytoma, isocitrate dehydrogenase (IDH) wild-type (AAw), 18 cases (16.0%) of anaplastic astrocytoma, IDH-mutant, and 33 cases (29.2%) of anaplastic oligodendroglioma, IDH-mutant and 1p/19q-codeleted. Results The median overall survival (OS) was 48.4 months in the whole anaplastic glioma group and 21.5 months in AAw group. In multivariate analysis, age, preoperative Karnofsky Performance Scale score, O 6-methylguanine-DNA methyltransferase (MGMT) methylation status, postoperative tumor volume, and EOR measured from the T2 MRI sequence were significant prognostic factors. The EOR cutoff point for OS measured in contrast-enhanced T1-weighted MRI and T2-weighted MRI were 99.96% and 85.64%, respectively. Conclusion We found that complete resection of the contrast-enhanced portion (99.96%) and more than 85.64% resection of the non-enhanced portion of the tumor have prognostic impacts on patient survival from anaplastic glioma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Survival, Prognostic Factors, and Volumetric Analysis of Extent of Resection for Anaplastic Gliomas

et al. 2020

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“…To determine the residual tumor after operation, preoperative MRI scans and MR images within 3 days after operation were compared on tissue volumes [18]. Enhancement which was defined as partial regions of the tumor showed a significant increase in the signal intensity on contrast-enhanced T1-W images [19,20] (Figure 1). The signal intensity from the marked enhanced area can be close to that of fat.…”

Section: Methodsmentioning

confidence: 99%

“…Depending upon the morphology of the largest enhanced region in the tumor, the patterns of enhancement were divided into three categories: focal enhancement, diffuse enhancement and ring-like enhancement. The focal enhancement pattern was defined as a well-defined enhancing area with a relatively smooth border [20] (Figure 1B). In contrast, the diffuse enhancement pattern was defined as a not well-defined enhancing area with rough border [20] (Figure 1C).…”

Section: Methodsmentioning

confidence: 99%

“…The focal enhancement pattern was defined as a well-defined enhancing area with a relatively smooth border [20] (Figure 1B). In contrast, the diffuse enhancement pattern was defined as a not well-defined enhancing area with rough border [20] (Figure 1C). The ring-like enhancement pattern was defined as a cystic necrosis surrounding by a contrast-enhanced border [19,20] (Figure 1D).…”

Section: Methodsmentioning

confidence: 99%

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Prognostic value of magnetic resonance imaging features in low-grade gliomas

et al. 2019

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Introduction: The treatment strategy for low-grade gliomas (LGGs) is still controversial, and there are no standardized criteria to predict the prognosis of patients with LGGs. Magnetic resonance imaging (MRI) is a routine test for preoperative diagnosis for LGG and can reflect the destructive features for the tumor. In the present study, we aimed to explore the relationship between the MRI features and prognosis in patients with LGG. Methods: Clinical data of 80 patients with pathologically proved LGGs between January 2010 and December 2016 were analyzed retrospectively. MRI features were classified as contrast enhancement pattern (focal enhancement, diffuse enhancement and ring-like enhancement), necrosis and cysts based on the preoperative MR images. Kaplan–Meier method and multivariate analysis were performed on the data by SPSS software to explore the prognostic significance of MRI features. Results: Patients with cystic LGG had a significantly longer 5-year progression-free survival (PFS) than that with no cyst (90.9 ± 8.7 vs 65.7 ± 9.1%, P=0.045). Multivariate analysis further verified cyst as an independent prognosis factor for PFS (P=0.027, hazard ratio [HR] = 0.084). Additionally, patients with ring-like enhancement exhibited significantly longer 5-year PFS time in the Kaplan–Meier survival curves (100 vs 67.2 ± 7.7%, P=0.049). There was no significant difference in PFS and overall survival (OS) between patients with or without necrosis. Conclusion: Our study suggests that cyst formation and ring-like enhancement on preoperative MR images can be useful to predict a favorable prognosis in patients with LGGs.

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MRI Morphometry in Brain Tumors: Challenges and Opportunities in Expert, Radiomic, and Deep-Learning-Based Analyses

et al. 2020

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Identifying the association between contrast enhancement pattern, surgical resection, and prognosis in anaplastic glioma patients

Abstract: Our results suggested that the contrast enhancement pattern on preoperative MR images was associated with the extent of resection and predictive of survival outcomes in AG patients.

Cited by 17 publications

References 30 publications

Survival, Prognostic Factors, and Volumetric Analysis of Extent of Resection for Anaplastic Gliomas

Survival, Prognostic Factors, and Volumetric Analysis of Extent of Resection for Anaplastic Gliomas

Prognostic value of magnetic resonance imaging features in low-grade gliomas

MRI Morphometry in Brain Tumors: Challenges and Opportunities in Expert, Radiomic, and Deep-Learning-Based Analyses

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