Identifying glioblastoma margins using dual-targeted organic nanoparticles for efficient <i>in vivo</i> fluorescence image-guided photothermal therapy

Cai, Xiaolei; Bandla, Aishwarya; Chuan, Chan Kim; Magarajah, Gayathiri; Liao, Lun-De; Teh, Daniel Boon Loong; Kennedy, Brian K.; Thakor, Nitish V.; Liu, Bin

doi:10.1039/c8mh00946e

Cited by 53 publications

(60 citation statements)

References 31 publications

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“…Conventional GBM treatments are often limited by their brain‐targeted delivery efficiency due to the presence of blood–brain barrier (BBB) and blood–brain tumor barrier (BBTB) . In GBM at the early stage, BBB acts as the major barrier for brain targeted delivery and the protector for growth of tumor cells .…”

Section: Resultsmentioning

confidence: 99%

Nanostructural Control Enables Optimized Photoacoustic–Fluorescence–Magnetic Resonance Multimodal Imaging and Photothermal Therapy of Brain Tumor

Duan

Guo

et al. 2019

Adv Funct Materials

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The performance of current multimodal imaging contrast agents is often constrained by the tunability of nanomaterial structural design. Herein, the influence of nanostructure on the overall imaging performance of a composite nanomaterial for multimodal imaging of brain tumors is studied. Newly designed near-infrared molecules (TC1) are encapsulated into nanocomposites with ultrasmall iron oxide nanoparticles (UIONPs), forming stable nanoagents for multimodal imaging and photothermal therapy (PTT). Through a modified nanoprecipitation method, the synthesis of nanocomposites denoted as HALF is realized, in which UIONPs are restricted to half of the nanosphere. Such a unique nanostructure that physically separates TC1 and UIONPs is found with capabilities of mitigating fluorescence quenching, preserving the good performance of photoacoustic imaging, and enhancing the magnetic resonance imaging signals. Decorated with a peptide ligand cRGD for better brain tumor targeting, HALF-cRGD is evaluated both in vitro and in vivo as imaging contrast agents and photothermal therapeutic agents. The good imaging performance and PTT effect of HALF-cRGD in mice models indicate that the rational design and control of nanostructures could optimize multimodal imaging performance using the same components.

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Section: Resultsmentioning

confidence: 99%

Nanostructural Control Enables Optimized Photoacoustic–Fluorescence–Magnetic Resonance Multimodal Imaging and Photothermal Therapy of Brain Tumor

Duan

Guo

et al. 2019

Adv Funct Materials

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“…Additionally, an ideal organic PTA should also possess good photothermal conversion efficiency, high photostability and photothermal stability, precise lesion site accumulation, and more importantly, simultaneous imaging (e.g., fluorescent and photoacoustic) and PTT capabilities. AIE‐active PTAs ( Scheme ) can be ideal alternatives, and have shown good performance in image‐guided PTT 111c,116e,123…”

Section: Image‐guided Therapymentioning

confidence: 99%

“…It has been hypothesized that combining PAI and PTT together will be a more effective strategy for cancer theranostics 116e,123b,c. For example, Cai et al123b reported that the introduction of propeller AIE units could significantly enhance PA signals and photothermal conversion efficiencies. The NIR‐absorbing/fluorescent (724/870 nm) compound BTPETTQ was obtained by connecting a TTQ core with two propeller AIE‐active TPE units.…”

Section: Image‐guided Therapymentioning

confidence: 99%

“…Qi et al123d also reported an NIR‐absorbing (≈780 nm) small molecule (TPA‐T‐TQ), which was comprised the electron‐donor (TPA), the electron‐acceptor (thiadiazoloquinoxaline, TQ), and a π‐conjugation unit (thiophene, T). Biocompatible organic nanoparticles (ONPs), namely TPA‐T‐TQ ONPs, were prepared through a nanoprecipitation method ( Figure A) and exhibited similar NIR‐absorbing properties as TPA‐T‐TQ.…”

Section: Image‐guided Therapymentioning

confidence: 99%

Section: Image‐guided Therapymentioning

confidence: 99%

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Promising Applications of AIEgens in Animal Models

Situ

Zhao

et al. 2019

Small Methods

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organisms cannot be achieved from these static findings. Therefore, gaining in-depth insights into biological and physiological functions at the in vivo level is of great significance, and various imaging techniques have been explored for this purpose. [1] In addition to the clinically available magnetic resonance imaging (MRI), ultrasonic imaging, computed tomography (CT), positron emission tomography (PET), and single-photon emission computed tomography, fluorescence imaging (another distinct type of optical imaging [1c] from bioluminescence imaging [2] ) has attracted increasing attention, owing to its advantages of high temporal-spatial resolution and sensitivity, noninvasive, and real-time applications, and the ability to provide dynamic information for basic research and (pre-)clinical settings at cellular and subcellular levels. [3] Fluorescent probes or contrast agents are essential for fluorescence imaging. Compared with fluorescent proteins, [4] inorganic nanoparticles (NPs), [5] such as quantum dots, [6] upconversion NPs, [7] and metallic NPs, [8] and organic dyes [9] (e.g., U.S. Food and Drug Administration (FDA)-approved 5-ALA, indocyanine green (ICG), and methylene blue), organic NPs [10] have obvious advantages, such as easy preparation and good biocompatibility. However, many organic NPs show weak fluorescence because they are made with conventional organic dyes, which suffer from the aggregation-caused quenching (ACQ) effect, i.e., their fluorescence is partially or completely quenched in the aggregated state.The advent of the aggregation-induced emission (AIE) concept offers a new strategy to deal with ACQ. [11] AIE refers to the interesting photophysical phenomenon that luminogens are weakly fluorescent or nonfluorescent in solution but show greatly enhanced emission in the aggregated state, primarily because of restricted intramolecular motion. [12] The past 19 years have witnessed spectacular advances of AIEgens, [13] due to their advantages of structural variety, easy functionalization, strong luminescence, large Stokes shift, high photobleaching-resistance, and so on. In particular, various AIE bioprobes have been designed: [14] (i) water-soluble AIEgens, which are comprised of a hydrophobic AIE core and hydrophilic units (e.g., ionic groups, peptides, carbohydrates, DNA, aptamers, antibodies, and poly(ethylene glycol) (PEG)); (ii) bare AIEgen dots (nanoaggregates); iii) AIEgen/biopolymer dots, which can be obtained by loading AIEgens onto biopolymer matrixes covalently (e.g., chitosan, dextran, and starch) or noncovalently (e.g., bovine serum albumin, human serum albumin (HSA), and fetal bovine serum (FBS)); (iv)In vivo investigations using small animal models are of great significance for the comprehensive understanding of biological and physiological functions-seeing is believing. Fluorescence imaging can provide real-time and dynamic information of living systems. During the past few years, aggregation-induced emission luminogens (AIEgens) are widely and rapidly developed for biolog...

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Precise Molecular Design for High‐Performance Luminogens with Aggregation‐Induced Emission

2019

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Precise design of fluorescent molecules with desired properties has enabled the rapid development of many research fields. Among the different types of optically active materials, luminogens with aggregation‐induced emission (AIEgens) have attracted significant interest over the past two decades. The negligible luminescence of AIEgens as a molecular species and high brightness in aggregate states distinguish them from conventional fluorescent dyes, which has galvanized efforts to bring AIEgens to a wide array of multidisciplinary applications. Herein, the useful principles and emerging structure–property relationships for precise molecular design toward AIEgens with desirable properties using concrete examples are revealed. The cutting‐edge applications of AIEgens and their excellent performance in enabling new research directions in biomedical theranostics, optoelectronic devices, stimuli‐responsive smart materials, and visualization of physical processes are also highlighted.

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Identifying glioblastoma margins using dual-targeted organic nanoparticles for efficient in vivo fluorescence image-guided photothermal therapy

Abstract: Dual-targeted organic nanoparticles efficiently target the margin of glioblastoma and successfully suppress the tumour growth through photothermal therapy.

Cited by 53 publications

References 31 publications

Nanostructural Control Enables Optimized Photoacoustic–Fluorescence–Magnetic Resonance Multimodal Imaging and Photothermal Therapy of Brain Tumor

Nanostructural Control Enables Optimized Photoacoustic–Fluorescence–Magnetic Resonance Multimodal Imaging and Photothermal Therapy of Brain Tumor

Promising Applications of AIEgens in Animal Models

Precise Molecular Design for High‐Performance Luminogens with Aggregation‐Induced Emission

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