Precise Molecular Design for High‐Performance Luminogens with Aggregation‐Induced Emission

Xu, Shidang; Duan, Yukun; Liu, Bin

doi:10.1002/adma.201903530

Cited by 358 publications

(339 citation statements)

References 198 publications

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“…[34] Meanwhile, AIE has great potential for a myriad of applications. [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] For example, recent literature reports have explored the practical applications of AIE luminogens (AIEgens), as components of electronic devices, [52][53][54][55][56][57][58][59] chemo-/biosensors, [60][61][62][63][64][65][66] bioimaging agents, [67][68][69][70][71][72] and theranostics. [73][74][75][76][77][78] By contrasting AIE with ACQ, we can conclude that molecular-level theories and properties do not necessarily correlate with properties of aggregates.…”

Section: Introductionmentioning

confidence: 99%

Aggregate Science: From Structures to Properties

et al. 2020

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Molecular science entails the study of structures and properties of materials at the level of single molecules or small interacting complexes of molecules. Moving beyond single molecules and well‐defined complexes, aggregates (i.e., irregular clusters of many molecules) serve as a particularly useful form of materials that often display modified or wholly new properties compared to their molecular components. Some unique structures and phenomena such as polymorphic aggregates, aggregation‐induced symmetry breaking, and cluster excitons are only identified in aggregates, as a few examples of their exotic features. Here, by virtue of the flourishing research on aggregation‐induced emission, the concept of “aggregate science” is put forward to fill the gaps between molecules and aggregates. Structures and properties on the aggregate scale are also systematically summarized. The structure–property relationships established for aggregates are expected to contribute to new materials and technological development. Ultimately, aggregate science may become an interdisciplinary research field and serves as a general platform for academic research.

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Section: Introductionmentioning

confidence: 99%

Aggregate Science: From Structures to Properties

et al. 2020

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“…[9,15] Based on this mechanism, AIE molecules can be constructed by incorporating typical AIEgens,s uch as tetraphenylethene,h exaphenylsilole,a nd distyreneanthracene,into the molecular structure. [16] Thestrong fluorescence intensity in the aggregated state and the variety of potential synthetic routes make AIE molecules one of the most important classes of fluorophores.T he AIE fluorophores in nanoparticles provide promising platforms for fluorescence imaging. [1a] Several reports have demonstrated the development of AIE nanoparticles for NIR-II imaging applications.…”

Section: Introductionmentioning

confidence: 99%

Semiconducting Polymer Dots with Dual‐Enhanced NIR‐IIa Fluorescence for Through‐Skull Mouse‐Brain Imaging

et al. 2020

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Fluorescence probes in the NIR‐IIa region show drastically improved imaging owing to the reduced photon scattering and autofluorescence in biological tissues. Now, NIR‐IIa polymer dots (Pdots) are developed with a dual fluorescence enhancement mechanism. First, the aggregation induced emission of phenothiazine was used to reduce the nonradiative decay pathways of the polymers in condensed states. Second, fluorescence quenching was minimized by different levels of steric hindrance to further boost the fluorescence. The resulting Pdots displayed a fluorescence QY of ca. 1.7 % in aqueous solution, suggesting an enhancement of ca. 21 times in comparison with the original polymer in tetrahydrofuran (THF) solution. Small‐animal imaging by using the NIR‐IIa Pdots exhibited a remarkable improvement in penetration depth and signal to background ratio, as confirmed by through‐skull and through‐scalp fluorescent imaging of the cerebral vasculature of live mice.

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“…They offer weak fluorescence when molecularly dissolved in good solvents. However, their emissions are greatly amplified in the aggregated state or in a confined environment owing to the restriction of intramolecular motion (RIM) [ [95] , [96] , [97] ]. In combination of AIE feature and lysosome degradation of mAb-receptor complex after internalization, Tang’s group developed a new antibody-AIEgen conjugate with “turn-on” fluorescence ( Fig.…”

Section: Assessment Of Biological Functionsmentioning

confidence: 99%

Recent progress in the molecular imaging of therapeutic monoclonal antibodies

Zeng

Qian

2020

Journal of Pharmaceutical Analysis

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Therapeutic monoclonal antibodies have become one of the central components of the healthcare system and continuous efforts are made to bring innovative antibody therapeutics to patients in need. It is equally critical to acquire sufficient knowledge of their molecular structure and biological functions to ensure the efficacy and safety by incorporating new detection approaches since new challenges like individual differences and resistance are presented. Conventional techniques for determining antibody disposition including plasma drug concentration measurements using LC-MS or ELISA, and tissue distribution using immunohistochemistry and immunofluorescence are now complemented with molecular imaging modalities like positron emission tomography and near-infrared fluorescence imaging to obtain more dynamic information, while methods for characterization of antibody’s interaction with the target antigen as well as visualization of its cellular and intercellular behavior are still under development. Recent progress in detecting therapeutic antibodies, in particular, the development of methods suitable for illustrating the molecular dynamics, is described here.

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Precise Molecular Design for High‐Performance Luminogens with Aggregation‐Induced Emission

Cited by 358 publications

References 198 publications

Aggregate Science: From Structures to Properties

Aggregate Science: From Structures to Properties

Semiconducting Polymer Dots with Dual‐Enhanced NIR‐IIa Fluorescence for Through‐Skull Mouse‐Brain Imaging

Recent progress in the molecular imaging of therapeutic monoclonal antibodies

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