Identifying a marked inflammation mediated cardiac dysfunction during the development of arthritis in collagen-induced arthritis mice

Zhou, Zihao; Miao, Zhengyue; Luo, Aishu; Zhu, Didi; Lü, Yan; Feng, Xiaoke; Tan, Wenfeng; Wang, Fang

doi:10.55563/clinexprheumatol/6kxs1o

Cited by 13 publications

(6 citation statements)

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“…HF may also be investigated as a potential comorbidity of the induction of experimental inflammatory arthritis. Zhou and colleagues (94) reported myocardial inflammation and fibrosis, up‐regulated expression of TNF, IL‐6, IL‐17, and MMP‐3 genes in cardiomyocytes and cardiac fibroblasts, and a decline in LV function in mice with collagen‐induced arthritis. Additional work in animal models with concurrent inflammatory arthritis and HF could aid in defining shared molecular pathways between the two processes.…”

Section: Introductionmentioning

confidence: 99%

Myocardial Dysfunction and Heart Failure in Rheumatoid Arthritis

Park

Griffin

Bathon

2021

Arthritis & Rheumatology

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Rheumatoid arthritis (RA) patients have almost twice the risk of heart failure (HF) as individuals without RA, even with adjustment for the presence of ischemic heart disease. Moreover, RA patients remain at a 2-fold higher risk of mortality from HF compared to non-RA patients. These observations suggest that RA-specific inflammatory pathways are significant contributors to this increased risk of HF. Herein we summarize the epidemiology of HF in RA patients, the differences in myocardial structure or function between RA patients and non-RA patients without clinical signs of HF, and data on the role of systemic and local inflammation in RA HF pathophysiology. We also discuss the impact of subduing inflammation through the use of RA disease-modifying therapies on HF and myocardial structure and function, emphasizing gaps in the literature and areas needing further research.

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Section: Introductionmentioning

confidence: 99%

Myocardial Dysfunction and Heart Failure in Rheumatoid Arthritis

Park

Griffin

Bathon

2021

Arthritis & Rheumatology

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“…Chronic simulation of inflammatory factors in autoimmune disease can cause inflammatory damage of cardiomyocytes, which lead to cardiac damage. Cardiac dysfunction caused by inflammation have been reported in animal models as well ( 70 ). The importance of senescent immunity in autoimmune disease heart damage has not been officially proven and requires further research, which also provides another direction for our future research.…”

Section: Discussionmentioning

confidence: 99%

Cardiac damage in autoimmune diseases: Target organ involvement that cannot be ignored

et al. 2022

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Autoimmune diseases are diseases that cause damage to the body’s own tissues as a result of immune dysfunction, often involving multiple organs and systems. The heart is one of the common target organs of autoimmune diseases. The whole structure of the heart can be affected, causing microcirculatory disorders, arrhythmias, pericardial damage, myocarditis, myocardial fibrosis, and impaired valvular function. However, early clinical manifestations of autoimmune heart damage are often overlooked because they are insidious or have no typical features. The damage is often severe and irreversible when symptoms are apparent, even life-threatening. Therefore, early detection and treatment of heart damage in autoimmune diseases is particularly important. Herein, we review the clinical features and mechanisms of cardiac damage in common rheumatic diseases.

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“…The dynamic outcome was essentially consistent with previous research on the CIA model ( 25 , 26 ). This demonstrated that CIA is an ideal model to investigate the pathological and mechanism changes during the development of RA, primarily during the following three phases: induction, peak, and resolution ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

Analysis of Hepatic Lipid Metabolism and Immune Function During the Development of Collagen-Induced Arthritis

et al. 2022

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The liver is essential for metabolic and immune functions and has been linked to systemic inflammatory diseases. However, the role of the liver is still elusive during the development of rheumatoid arthritis (RA), although there have been indeed some reports. We used label-free quantitative proteomics and experimental verification in this study to reveal the hepatic lipid metabolism and immune function during collagen-induced arthritis (CIA) development. The proteomics results revealed that the role of the liver differs in different phases of CIA rats. In terms of specific performance, hepatic lipid metabolism, which is primarily concerned with cholesterol, triacylglycerol, and phospholipid, was significantly influenced in the CIA induction phase, whereas the immune function, which includes binding of granulocytes, adhesion of immune cells, etc., was affected considerably at the peak phase of CIA rats compared to normal rats. Finally, the hepatic dynamic changes in CIA rats were further confirmed using targeted metabolomics and ELISA. We found that most fatty acids of the liver in the CIA induction phase were significantly decreased, and proteins related to complement activation and migration or adhesion of immune cells including C3, MMP-8, CTSZ, and S100A9 were significantly increased in the liver of CIA rats in the peak phase. Our findings indicated that the lipid metabolism and immune function of the liver were influenced in CIA rats. Thus, the conditions of the liver during RA development should be considered in therapeutic and nutritional interventions.

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Identifying a marked inflammation mediated cardiac dysfunction during the development of arthritis in collagen-induced arthritis mice

Cited by 13 publications

References 0 publications

Myocardial Dysfunction and Heart Failure in Rheumatoid Arthritis

Myocardial Dysfunction and Heart Failure in Rheumatoid Arthritis

Cardiac damage in autoimmune diseases: Target organ involvement that cannot be ignored

Analysis of Hepatic Lipid Metabolism and Immune Function During the Development of Collagen-Induced Arthritis

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