Identify production area, growth mode, species, and grade of Astragali Radix using metabolomics “big data” and machine learning

Wu, Jing; Deng, Shaoqian; Yu, Xinyue; Wu, Yanlin; Hua, Xiaoyi; Zhang, Zunjian; Huang, Yin

doi:10.1016/j.phymed.2023.155201

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Phytomedicine

2024

DOI: 10.1016/j.phymed.2023.155201

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Identify production area, growth mode, species, and grade of Astragali Radix using metabolomics “big data” and machine learning

Jing Wu,

Shaoqian Deng,

Xinyue Yu

et al.

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2024

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Cited by 2 publications

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“…Compared with HPLC, the sensitivity of UPLC-MS/MS is much higher, and because it benefits from a low detection limit and low sample consumption, UPLC-MS/MS is widely used in pharmaceutical analysis for evaluating chemical composition (Lu et al, 2023;Wu et al, 2023;Zhang et al, 2023;Zhao et al, 2023), elucidating drug metabolism, and identifying impurities (Famiglini et al, 2021;Nasiri et al, 2021). Therefore, this study sought to establish a UPLC-MS/ MS method for measuring the concentrations of crassicauline A, fuziline, karacoline, and songorine in rat plasma.…”

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confidence: 99%

Development of an ultra‐high‐performance liquid chromatography–tandem mass spectrometry method for the simultaneous determination of crassicauline A, fuziline, karacoline, and songorine in rat plasma and application in their pharmacokinetics

Chen,

Wang,

Luo

et al. 2024

Biomedical Chromatography

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In this paper, an ultra‐high‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was developed for quantifying the levels of crassicauline A, fuziline, karacoline, and songorine in rat plasma. After processing the rat plasma, the proteins in the plasma were separated by extracting the analytes with acetonitrile–methanol (9:1, v/v). The chromatographic column used was the UPLC HSS T3 column, and the mobile phase (methanol–water with 0.1% formic acid) under a gradient elution profile was used to separate the four compounds, with elution times for each analyte being less than 5 min. Electrospray ionization in positive‐ion mode and operating in multiple reaction monitoring mode was used for quantitative analysis. Crassicauline A, fuziline, karacoline, and songorine were administered to 48 rats (n = 6 per group) orally (5 mg/kg) and intravenously (0.5 mg/kg). The standard curves demonstrated excellent linearity in the range of 1–2500 ng/mL, wherein all r values were greater than 0.99. The UPLC–MS/MS method for the determination of crassicauline A, fuziline, karacoline, and songorine in rat plasma was successfully applied in determining their pharmacokinetics parameters, from which their oral bioavailabilities were calculated to be 18.7%, 4.3%, 6.0%, and 8.4%, respectively.

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mentioning

confidence: 99%

Development of an ultra‐high‐performance liquid chromatography–tandem mass spectrometry method for the simultaneous determination of crassicauline A, fuziline, karacoline, and songorine in rat plasma and application in their pharmacokinetics

Chen,

Wang,

Luo

et al. 2024

Biomedical Chromatography

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Germplasm Resources and Genetic Breeding of Huang-Qi (Astragali Radix): A Systematic Review

Dong,

Wang,

Chen

et al. 2024

Biology

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Huang-Qi (Astragali radix) is one of the most widely used herbs in traditional Chinese medicine, derived from the dried roots of Astragalus membranaceus or Astragalus membranaceus var. mongholicus. To date, more than 200 compounds have been reported to be isolated and identified in Huang-Qi. However, information pertaining to Huang-Qi breeding is considerably fragmented, with fundamental gaps in knowledge, creating a bottleneck in effective breeding strategies. This review systematically introduces Huang-Qi germplasm resources, genetic diversity, and genetic breeding, including wild species and cultivars, and summarizes the breeding strategy for cultivars and the results thereof as well as recent progress in the functional characterization of the structural and regulatory genes related to horticultural traits. Perspectives about the resource protection and utilization, breeding, and industrialization of Huang-Qi in the future are also briefly discussed.

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Identify production area, growth mode, species, and grade of Astragali Radix using metabolomics “big data” and machine learning

Cited by 2 publications

References 30 publications

Development of an ultra‐high‐performance liquid chromatography–tandem mass spectrometry method for the simultaneous determination of crassicauline A, fuziline, karacoline, and songorine in rat plasma and application in their pharmacokinetics

Development of an ultra‐high‐performance liquid chromatography–tandem mass spectrometry method for the simultaneous determination of crassicauline A, fuziline, karacoline, and songorine in rat plasma and application in their pharmacokinetics

Germplasm Resources and Genetic Breeding of Huang-Qi (Astragali Radix): A Systematic Review

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