Identifikasi Metabolit Sekunder dan Aktivitas Antibakteri Ekstrak Daun Sungkai (Peronema canescens JACK.) terhadap Beberapa Bakteri Patogen

Ibrahim, Arsyik; Kuncoro, Hadi

doi:10.25026/jtpc.v2i1.43

Cited by 43 publications

(47 citation statements)

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“…Somehow, it also uses for women after childbirth and as a mouthwash to prevent toothache. 11,12 Previous studies were reported that P. canescens) contain several bioactive compound, and the bioactive compound might act as antimalarial, antiplasmodial, 13 antibacterial, 14 analgesic, and immunomodulator. 15 P. canescens leaves contains bioactive compound such as flavonoids, alkaloids, steroids, tannins, phenol, and saponins.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Activity of Sungkai (Peronema canescens Jack) Leaves Ethanol Extract on the Male Mice Induced Alloxan Monohydrate

Latief

Sari

Fatwa

et al. 2021

Pharmacology and Clinical Pharmacy Research (PCPR) is an intern

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Sungkai (Peronema canescens Jack) is an alternative natural ingredient that can be used as an antidiabetic containing several secondary metabolites which are thought to reduce blood glucose levels by inhibiting the action of the α-glucokinase enzyme and increasing the activity of antioxidant enzymes and being able to regenerate β-cells, damaged pancreas so that insulin deficiency can be overcome. The aim of this study was to determine the effect of P. canescens leaves ethanol extract on antidiabetic activity and to determine the effect of various doses of sungkai leaf ethanol extract as antidiabetic. The scientific research method used in this study was a completely randomized design (CRD) and data analysis used in this study is the one way ANOVA, following by the Duncan test. Blood glucose measurement in treated mice was carried out 3 times. Mice were devided into five groups, three mice in each group, and each group was administered different dosages of sungkai extract (T1 = extract 175 mg/kg body weight; T2 = extract 350 mg/kg body weight; T3 = extract 700 mg/ kg body weight). First, the mice were acclimatized for six days and the injection of treatment was started at day 7. Blood glucose levels, urine volume, body weight and daily drinking of mice was carried out before induction (day 0), after induction (day 8) and after the end of treatment for 10 days (day 18), was carried out using the Point of Care Test (POCT) method using the Easy Touch GCU. The results showed that the ethanol extract of sungkai leaves had the potential to reduce blood glucose levels in mice. The ethanol extract of sungkai leaves at a dose of 350 mg/kg body weight has the most optimal potential to reduce blood glucose levels, urine volume, daily drinking, and body weight.

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Section: Introductionmentioning

confidence: 99%

Antidiabetic Activity of Sungkai (Peronema canescens Jack) Leaves Ethanol Extract on the Male Mice Induced Alloxan Monohydrate

Latief

Sari

Fatwa

et al. 2021

Pharmacology and Clinical Pharmacy Research (PCPR) is an intern

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“…Flavonoid memiliki aktivitas untuk menghambat pertumbuhan bakteri dengan cara mendenaturasi protein yang menyebabkan terhentinya aktivitas metabolisme sel bakteri, dengan terhentinya aktivitas metabolisme mengakibatkan kematian pada sel. Flavonoid lipofilik dapat membentuk senyawa kompleks dengan protein ekstraseluler sehingga mengganggu integritas membran sel bakteri [33,[35][36]. Tanin diduga dapat mengerutkan dinding sel sehingga mengganggu permeabilitas sel bakteri [35].…”

Section: Hasil Uji Aktivitas Antibakteriunclassified

“…Flavonoid lipofilik dapat membentuk senyawa kompleks dengan protein ekstraseluler sehingga mengganggu integritas membran sel bakteri [33,[35][36]. Tanin diduga dapat mengerutkan dinding sel sehingga mengganggu permeabilitas sel bakteri [35]. Selain itu, tanin diduga mengganggu kerja DNA gyrase, yaitu enzim yang berperan dalam replikasi DNA [37].…”

Section: Hasil Uji Aktivitas Antibakteriunclassified

“…Golongan senyawa terpenoid diduga dapat merusak dinding sel bakteri dengan jalan mengganggu komponen petidoglikan sel bakteri. Hal tersebut menyebabkan lapisan dinding sel mengalami kerusakan, hingga sel bakteri menjadi lisis dan mengalami kematian [35]. Saponin diduga memiliki aktivitas antibakteri karena zat aktif pada saponin mirip detergen, akibatnya saponin akan menurunkan tegangan permukaan dinding sel bakteri dan merusak permeabilitas membran.…”

Section: Hasil Uji Aktivitas Antibakteriunclassified

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Antibacterial Activity of Grape Seeds Extracts (Vitis vinifera L.) Against Streptococcus mutans ATCC 31987

et al. 2021

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ABSTRAK Streptococcus mutans merupakan salah satu bakteri penyebab karies gigi. Penggunaan antibiotic merupakan terapi infeksi yang umum dilakukan untuk menghambat pertumbuhan bakteri. Biji anggur diketahui mengandung senyawa polifenol yang berpotensi sebagai antibakteri. Tujuan penelitian ini untuk mengetahui aktivitas ektrak biji anggur terhadap Streptococcus mutans. Bahan uji yang digunakan adalah buah anggur yang diambil bijinya. Buah anggur diperoleh dari Pasar Induk, Kramat Jati, Jakarta Timur. Ekstrak biji anggur diperoleh dengan metode maserasi menggunakan pelarut etil asetat dan etanol 70%. Uji aktivitas antibakteri dilakukan menggunakan metode difusi cakram pada media Mueller Hinton Agar dengan konsentrasi 5%, 10%, 20%, dan 40%. Hasil penelitian menunjukkan bahwa ekstrak etanol 70% biji anggur memiliki aktivitas antibakteri pada konsentrasi 5%, 10%, 20%, dan 40% dengan nilai hambatan secara berurutan sebesar 8,46 mm; 8,91 mm; 9,89 mm; dan 11,04 mm. Hasil pada ekstrak etil asetat juga menunjukkan ada aktivitas penghambatan pada konsentrasi 5%, 10%, 20%, dan 40% dengan nilai hambatan secara berurutan sebesar 7,72 mm; 8,50 mm; 9,64 mm; dan 10,51 mm. Ekstrak etanol 70% biji anggur memiliki daya hambat yang lebih besar dibandingkan dengan ekstrak etil asetat. Hasil ini dapat menjadi acuan untuk pengembangan potensi biji anggur sebagai bahan obat atau kosmedik (kosmetik-medik) penanganan karies gigi. ABSTRACT Streptococcus mutans is one of the bacteria that cause dental caries. The antibiotics usually used for the therapy of this infection to inhibit bacterial growth. Polyphenol, which recommended as an antibacterial agent, is common secondary metabolites in grape seeds. The purpose of this study is to know the activity of grape seed extract against Streptococcus mutans. The grape seeds were obtained from fresh fruits which bought from Pasar Induk, Kramat Jati, East Jakarta. The grape seed extract was obtained by the maceration method using ethyl acetate and 70% ethanol. The antibacterial activity test was carried out using the disk diffusion method on Mueller Hinton Agar media with a concentration of 5%, 10%, 20%, and 40%. The results showed that 70% ethanol extract of grape seeds had antibacterial activity at concentrations of 5%, 10%, 20%, and 40% with a value of 8.46 mm; 8.91 mm; 9.89 mm; and 11.04 mm respectively. The results of ethyl acetate extract also showed inhibitory activity at concentrations of 5%, 10%, 20%, and 40% with values of 7.72 mm; 8.50 mm; 9.64 mm; and 10.51 mm respectively. The inhibition of 70% ethanol extract of grape seed is greater than ethyl acetate extract. The results of the study can be used as reference for the potential development of grape seed as a medicinal or cosmedic cosmetic-medical) ingredient for treating dental caries.

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“…The P. canescens extract has been used for a long time as an herbal medicine to treat toothache, cold, fever, and ringworm [21]. The methanol extract of P. canescens leaves is known to contain secondary metabolites such as alkaloids, flavonoids, terpenoids, steroids, and tannins [22]. In addition, studies have shown that the extract of young leaves of P. canescens has good activity as an herbal medicine and a dosage of 0.5625 mg kg w/w can decrease the mice body temperature by up to 29% [23].…”

Section: Introductionmentioning

confidence: 99%

Reduction of 4-nitrophenol Mediated by Silver Nanoparticles Synthesized using Aqueous Leaf Extract of Peronema canescens

Falahudin

Wibowo

et al. 2021

Bull. Chem. React. Eng. Catal.

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In this study, we developed an alternative of 4-nitrophenol reduction mediated by silver nanoparticles (AgNPs) which was synthesized using aqueous extract of the Peronema canescens leaf through an eco-friendly approach. The reducing 4-nitrophenol to 4-aminophenol mediated by AgNPS in the presence of sodium borohydride as a hydrogen source proceeded rapidly at room temperature without any additional treatments. The AgNPS synthesis was simple and was carried out under mild conditions. Ultraviolet–visible spectroscopy was performed to examine the properties of the obtained AgNPs, which displayed an absorption peak at 431 nm. A transmission electron microscopy analysis revealed that the AgNPs were spherical in shape and had an average particle size of 19 nm as determined by particle size analysis. Copyright © 2021 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).

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Identifikasi Metabolit Sekunder dan Aktivitas Antibakteri Ekstrak Daun Sungkai (Peronema canescens JACK.) terhadap Beberapa Bakteri Patogen

Abstract: A research which identification of secondary metabolites and antibacterial activity test from methanol exstract of leaf Sungkai (Peronema canencensJack

Cited by 43 publications

References 0 publications

Antidiabetic Activity of Sungkai (Peronema canescens Jack) Leaves Ethanol Extract on the Male Mice Induced Alloxan Monohydrate

Antidiabetic Activity of Sungkai (Peronema canescens Jack) Leaves Ethanol Extract on the Male Mice Induced Alloxan Monohydrate

Antibacterial Activity of Grape Seeds Extracts (Vitis vinifera L.) Against Streptococcus mutans ATCC 31987

Reduction of 4-nitrophenol Mediated by Silver Nanoparticles Synthesized using Aqueous Leaf Extract of Peronema canescens

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