The article deals with drilling of titanium alloys, which are becoming more widely used in aerospace and automotive industry as well as in other sectors for its specific properties such as hardness, corrosion resistance, biocompatibility, etc. The aim of this article is basic research with focus on drilling conditions of titanium alloy using HSS drill bits with diameter ø2,3 mm with PVD coating and without coating on CNC turning machine Polygim Diamond 12 series. This research can support problem solutions in small diameter drilling.