Identification, Prevention and Treatment of Iron Deficiency during the First 1000 Days

Burke, Rachel M; León, Juan S.; Suchdev, Parminder S.

doi:10.3390/nu6104093

Cited by 108 publications

(119 citation statements)

References 97 publications

Supporting

Mentioning

109

Contrasting

Unclassified

Order By: Relevance

“…The maintenance of adequate iron stores is essential for the production of hemoglobin and the rapid expansion of red cell mass that occurs in young children, and iron deficiency during the first "1,000 days" of development has been linked to cognitive, motor, and behavioral deficits that can last into adulthood. 1,2 The first 30 months of age also represent a key window of vulnerability to severe malaria infection and death. 3,4 Until children have developed naturally acquired resistance against Plasmodium parasites, hepcidin plays a particularly valuable role in host defense.…”

Section: Introductionmentioning

confidence: 99%

Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study

Brickley

Spottiswoode

Kabyemela

et al. 2016

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Hepcidin, the master regulator of bioavailable iron, is a key mediator of anemia and also plays a central role in host defense against infection. We hypothesized that measuring hepcidin levels in cord blood could provide an early indication of interindividual differences in iron regulation with quantifiable implications for anemia, malaria, and mortality-related risk. Hepcidin concentrations were measured in cord plasma from a birth cohort (N = 710), which was followed for up to 4 years in a region of perennial malaria transmission in Muheza, Tanzania (2002Tanzania ( -2006. At the time of delivery, cord hepcidin levels were correlated with inflammatory mediators, iron markers, and maternal health conditions. Hepcidin levels were 30% (95% confidence interval [CI]: 12%, 44%) lower in children born to anemic mothers and 48% (95% CI: 11%, 97%) higher in placental malaria-exposed children. Relative to children in the lowest third, children in the highest third of cord hepcidin had on average 2.5 g/L (95% CI: 0.1, 4.8) lower hemoglobin levels over the duration of follow-up, increased risk of anemia and severe anemia (adjusted hazard ratio [HR]

show abstract

Section: Introductionmentioning

confidence: 99%

Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study

Brickley

Spottiswoode

Kabyemela

et al. 2016

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…The consequences of iron deficiency are expressed in adulthood, preventing the full realization of the inherent genetic potential [14][15][16][17][18].…”

mentioning

confidence: 99%

Anemia in Women of Reproductive Age

Solovyeva¹,

Gace²,

Ermolenko³

et al. 2018

Current Topics in Anemia

View full text Add to dashboard Cite

Anemia is a common condition in women of childbearing age which is associated with wide spread hyperplastic processes in the uterus (leiomyomas, etc.) and abnormal and/ or abundant uterine bleeding (AUB). Our study has considered the main causes of bleeding and the therapy aimed on limiting the amount of blood loss, as well as preoperative treatment of iron deficiency in women with uterine leiomyomas, planning for pregnancy.The combination of anemia with other abnormalities in the woman's health status is associated with complications during pregnancy such as premature births, the birth of small children and failure of the formation of neural tube in iron deficiency and hypoxia. During the treatment of iron deficiency anemia (IDA) with saline iron, we noted severity and pain in the stomach in 11.9% of patients, nausea in 13.1%, constipation in 21.4%, and diarrhea in 7.1% of women. Such complications did not occur while treating with ferric iron. The use of drugs Iron III hydroxide polymaltozate in women after the end of lactation resulted in normalization of the blood hemoglobin within 30 days and the number of erythrocytes and of serum ferritin by the 90th day.

show abstract

“…Anemia and iron deficiency are common during pregnancy [8,9]. A small decrease in hemoglobin (Hb) is a normal physiological consequence of the increase in blood plasma volume during pregnancy.…”

mentioning

confidence: 99%

“…Normally, after an initial increase (due to the cessation of menstruation), Hb levels decrease by around 20 g/l and reach their lowest level during the second trimester, returning to pre-pregnancy levels as the pregnancy advances toward Assessment of iron deficiency and anemia in pregnant women: an observational French study Thierry [8,10]. The increase in iron requirements during pregnancy results from increased total blood cell volume, the requirements of the fetus and placenta and, during labor, blood loss [9,10].…”

mentioning

confidence: 99%

Assessment of Iron Deficiency and Anemia in Pregnant Women: An Observational French Study

Harvey

Zkik

Augès

et al. 2016

Womens Health (Lond Engl)

View full text Add to dashboard Cite

Aim:We explored the prevalence and management of iron deficiency and anemia among pregnant women in France. Patients & methods: In this prospective, observational, multicenter registry study, randomly selected investigators (gynecologists/obstetricians/midwives registered in the CEGEDIM ® database) assessed pregnant women presenting for a consultation. Participants completed a questionnaire at study inclusion. Results: A total of 1506 patients were enrolled by 95 investigators. Overall, investigators estimated a moderate or significant risk of iron deficiency in almost 60% of women. The overall prevalence of anemia (15.8%) increased with longer pregnancy duration. Medication (mainly iron-based) was prescribed to 57.3% of patients. Conclusion: In French clinical practice, the estimated risk of iron deficiency and prevalence of anemia during pregnancy align with expectations and are managed according to national/international recommendations.

show abstract

Identification, Prevention and Treatment of Iron Deficiency during the First 1000 Days

Cited by 108 publications

References 97 publications

Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study

Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study

Anemia in Women of Reproductive Age

Assessment of Iron Deficiency and Anemia in Pregnant Women: An Observational French Study

Contact Info

Product

Resources

About