Identification of Very Small Embryonic/Epiblast-Like Stem Cells (VSELs) Circulating in Peripheral Blood During Organ/Tissue Injuries

Ratajczak, Mariusz Z.; Liu, Rui; Marlicz, Wojciech; Błogowski, Wojciech; Starzyńska, Teresa; Wojakowski, Wojciech; Zuba‐Surma, Ewa

doi:10.1016/b978-0-12-385493-3.00003-6

Cited by 47 publications

(39 citation statements)

References 63 publications

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“…This observation laid the foundation for the concept that G-CSF mobilization can be employed to harvest these cells from patients for therapeutic purposes in regenerative medicine. Several reports also provided evidence that VSELs are mobilized into PB during strenuous exercise, infections, and sepsis as well as in patients suffering from heart infarct, stroke, skin burns, active inflammatory bowel disease, and several types of cancer [83][84][85][86][87][88][89][90][91] More importantly, based on our preliminary data, we also envision that in several clinical situations the number of VSELs circulating in PB in patients could be of prognostic value. This possibility, however, requires further study and long-term clinical correlations.…”

Section: Mobilization Of Vsels Into Pb In Response To Stress and Tissmentioning

confidence: 85%

Very small embryonic-like stem cells as a novel developmental concept and the hierarchy of the stem cell compartment

Ratajczak

Marycz

Poniewierska-Baran

et al. 2014

Advances in Medical Sciences

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Section: Mobilization Of Vsels Into Pb In Response To Stress and Tissmentioning

confidence: 85%

Very small embryonic-like stem cells as a novel developmental concept and the hierarchy of the stem cell compartment

Ratajczak

Marycz

Poniewierska-Baran

et al. 2014

Advances in Medical Sciences

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“…Their quiescent state is comparable to that of the peripheral blood lymphocytes, whose metabolic rate and generation of oxidants is nearly two orders of magnitude lower that of their mitogenically stimulated counterparts [48, 49]. The metabolic rate of the most primitive stem cells, the “very small embryonic-epiblast stem cells”(VSELs), as judged from extreme paucity of their cytoplasmic content and few mitochondria, is expected to be indeed minimal [50]. …”

Section: Containing Danger Of Endogenous Oxidantsmentioning

confidence: 99%

Genome integrity, stem cells and hyaluronan

Darżynkiewicz

Balazs²

2012

Aging

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Faithful preservation of genome integrity is the critical mission of stem cells as well as of germ cells. Reviewed are the following mechanisms involved in protecting DNA in these cells: (a) The efflux machinery that can pump out variety of genotoxins in ATP-dependent manner; (b) the mechanisms maintaining minimal metabolic activity which reduces generation of reactive oxidants, by-products of aerobic respiration; (c) the role of hypoxic niche of stem cells providing a gradient of variable oxygen tension; (d) (e) the presence of hyaluronan (HA) and HA receptors on stem cells and in the niche; (f) the role of HA in protecting DNA from oxidative damage; (g) the specific function of HA in protecting DNA in stem cells; (h) the interactions of HA with sperm cells and oocytes that also may shield their DNA from oxidative damage, and (e) mechanisms by which HA exerts the anti-oxidant activity. While HA has multitude of functions its anti-oxidant capabilities are often overlooked but may be of significance in preservation of integrity of stem and germ cells genome.

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“…by treating with busulphan in female [31] and male [32] mice. Freshly prepared BM may also exhibit early tissue-specific markers but are up-regulated several folds when the function of organ is compromised [33].…”

Section: Trans-differentiation Of Bone Marrow Stem Cellsmentioning

confidence: 99%

“…They express several morphological (e.g., relatively large nuclei containing euchromatin) and molecular (e.g. expression of SSEA-1, Oct4, Nanog, Rex1) markers characteristic for embryonic stem cells (ESCs) [33]. The morphology of the cells was investigated using transmission electron microscopy which showed their distinctive morphology and size differentiating VSELs from HSC in particular in terms of size (3-6 μm vs. 6-8 μm for HSC), chromatin structure and nucleus/cytoplasm ratio.…”

Section: Very Small Embryonic Like Stem Cells (Vsels)mentioning

confidence: 99%