Identification of two urinary metabolites of rats treated with acrylonitrile; Influence of several inhibitors on the mutagenicity of those urines

Lambotte-Vandepaer, M.; Bogaert, M. Duverger-van; Meester, Conrad De; Rollmann, Bruno; Poncelet, F.; Mercier, Michel

doi:10.1016/0378-4274(81)90055-2

Cited by 23 publications

(2 citation statements)

References 10 publications

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“…Metabolism studies with [2,3-14C]AN did not result in the exhalation of significant amounts of 14C02 (37). Cyanoacetaldehyde has also been suggested as an intermediate in the production of cyanoacetic acid and cyanoethanol, both in vitro and in vivo (38). However, neither of these end products was detected as metabolites in this study.…”

Section: Discussioncontrasting

confidence: 63%

Urinary metabolites of [1,2,3-13C]acrylonitrile in rats and mice detected by carbon-13 nuclear magnetic resonance spectroscopy

Fennell

Kedderis²,

Sumner³

1991

Chem. Res. Toxicol.

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Section: Discussioncontrasting

confidence: 63%

Urinary metabolites of [1,2,3-13C]acrylonitrile in rats and mice detected by carbon-13 nuclear magnetic resonance spectroscopy

Fennell

Kedderis²,

Sumner³

1991

Chem. Res. Toxicol.

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“…In many of these experiments, metabolic activation with liver microsome fraction was required for induction of mutagenic response, but not essential. Urine from rats and mice receiving intraperitoneal injection of AN was positive to Ames test in the absence of S-9 mix (Lambotte-Vandepaer et al, 1980, 1981) 51,52) . The same was true on rats orally treated with AN (Lambotte-Vandepaer et al, 1985) 53) .…”

Section: Mutagenicitymentioning

confidence: 99%

Carcinogenicity and Other Health Effects of Acrylonitrile with Reference to Occupational Exposure Limit.

SAKURAI

2000

INDUSTRIAL HEALTH

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The occupational exposure limit for acrylonitrile (AN) has been set by many organizations on the basis of its carcinogenicity. However, recent epidemiological studies do not afford evidence supporting the hypothesis that AN is carcinogenic to humans. Review of the 18 published cohort studies revealed that, although there is not adequate evidence in humans for carcinogenicity of AN, the possibility of a causal association between high exposure to AN and lung cancer in humans cannot be excluded. It was pointed out that carcinogenic potential of AN may be weak, if any, to humans, and the current occupational exposure limit (OEL) for AN of 2 ppm was evaluated as appropriate in view of AN exposure levels reported by epidemiological studies. Based also on review of the literature on health effects other than carcinogenicity, it was concluded that the current OEL for AN is a reasonable value and there is no need for a revision at present.

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Acrylonitrile [BAT Value Documentation in German language, 1994]

Lewalter¹,

Bolt²

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Biologische Arbeitsstoff‐Toleranz‐Werte (BAT‐Werte) und Expositionsäquivalente für krebserzeugende Arbeitsstoffe (EKA) , 7. Lieferung, Ausgabe 1994 Der Artikel enthält folgende Kapitel: Metabolismus und Kinetik Metabolismus Kinetik Kritische Toxizität Krebserzeugende Wirkung Vegetatives Nervensystem Weitere Organe Auswahl geeigneter Indikatoren Empfohlene Untersuchungsmethoden Belastung und Beanspruchung Evaluierung Interpretation von Untersuchungsdaten

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Identification of two urinary metabolites of rats treated with acrylonitrile; Influence of several inhibitors on the mutagenicity of those urines

Cited by 23 publications

References 10 publications

Urinary metabolites of [1,2,3-13C]acrylonitrile in rats and mice detected by carbon-13 nuclear magnetic resonance spectroscopy

Urinary metabolites of [1,2,3-13C]acrylonitrile in rats and mice detected by carbon-13 nuclear magnetic resonance spectroscopy

Carcinogenicity and Other Health Effects of Acrylonitrile with Reference to Occupational Exposure Limit.

Acrylonitrile [BAT Value Documentation in German language, 1994]

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