Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients

Jiang, Jianming; Liu, Yu; Huang, Xinghua; Chen, Xiaosong; Li, Dan; Zhang, Yazhou; Tang, Long; Zhao, Shengming

doi:10.1016/s0378-1119(01)00787-9

Cited by 58 publications

(52 citation statements)

References 18 publications

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“…In 2008, there were 900,000 new cases of prostate carcinoma globally; therefore, prostate cancer has become the second most serious cancer in terms of its threat to men's health (21). The morbidity of prostate cancer is lower in East Asia; however, due to the aging population, dietary structure alterations and improvements in diagnosis, the morbidity is also rising in countries in this region (2). The present study observed that ursolic acid significantly suppressed cell growth, and induced apoptosis and caspase-3 and caspase-9 activity in DU145 cells.…”

Section: Discussionmentioning

confidence: 99%

“…In East Asia, the morbidity of prostate cancer is relatively low but has demonstrated a rising trend due to the aging population, dietary structure alterations and improvements in diagnosis (2). Prostate carcinoma is currently the focus of much research attention, and if identified early and treated correctly patient quality of life and treatment efficacy will be high (3).…”

Section: Introductionmentioning

confidence: 99%

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Anti-cancer effect of ursolic acid activates apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer

Gai

Wang

et al. 2016

Oncology Letters

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Abstract. Ursolic acid is a type of pentacyclic triterpene compound with multiple pharmacological activities including cancer resistance, protection from liver injury, antisepsis, anti-inflammation and antiviral activity. The present study aimed to investigate the anticancer effect of ursolic acid. Ursolic acid activates cell apoptosis and its pro-apoptotic mechanism remains to be fully elucidated. Cell Counting kit-8 assays, flow cytometric analysis and analysis of caspase-3 and caspase-9 activity were used to estimate the anticancer effect of ursolic acid on DU145 prostate cancer cells. The protein expression of cytochrome c, rho-associated protein kinase (ROCK), phosphatase and tensin homolog (PTEN) and cofilin-1 were examined using western blot analysis. In the present study, ursolic acid significantly suppressed cell growth and induced apoptosis, as well as increasing caspase-3 and caspase-9 activities of DU145 cells. Furthermore, cytoplasmic and mitochondrial cytochrome c protein expression was significantly activated and suppressed, respectively, by ursolic acid. Ursolic acid significantly suppressed the ROCK/PTEN signaling pathway and inhibited cofilin-1 protein expression in DU145 cells. The results of the present study indicate that the anticancer effect of ursolic acid activates cell apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-cancer effect of ursolic acid activates apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer

Gai

Wang

et al. 2016

Oncology Letters

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“…Changes in the relative expression levels of the roadblock light chains have also been observed. In hepatocellular carcinoma tissue, the expression levels of roadblock-1 and roadblock-2 are altered relative to control tissue samples (62). In addition, the roadblock-1 light chain is highly expressed in the visual cortex and upon sensory stimulation, its mRNA and protein levels are rapidly down-regulated (63).…”

Section: Discussionmentioning

confidence: 99%

The Roadblock Light Chain Binds a Novel Region of the Cytoplasmic Dynein Intermediate Chain

Susalka

Nikulina

Salata

et al. 2002

Journal of Biological Chemistry

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“…We have previously identified km23-1 as a TGF␤ receptorinteracting protein (23), which is also known as km23 (24 -28), mLC7-1 (23), Robl1 (29), DNLC2A (30), and DYNLRB1 (31). km23-1 interacts with and co-localizes in early endosomes with T␤RII and Smad2 after TGF␤ treatment (23,32).…”

mentioning

confidence: 99%

The TGFβ Receptor-interacting Protein km23-1/DYNLRB1 Plays an Adaptor Role in TGFβ1 Autoinduction via Its Association with Ras

Jin

Ding

Mulder

2012

Journal of Biological Chemistry

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Background:The TGF␤ receptor-interacting protein km23-1 plays an important role in TGF␤ signal transduction in TGF␤-sensitive epithelial cells. Results:The role of km23-1 in TGF␤ activation of Ras/JNK/ERK, as well as TGF␤1 autoinduction, was determined. Conclusion: km23-1 is required for TGF␤1 autoinduction through a Smad2-independent Ras/ERK/JNK pathway. Significance: km23-1 functions as a critical adaptor coupling TGF␤ receptors to Ras activation after TGF␤ treatment.

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Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients

Cited by 58 publications

References 18 publications

Anti-cancer effect of ursolic acid activates apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer

Anti-cancer effect of ursolic acid activates apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer

The Roadblock Light Chain Binds a Novel Region of the Cytoplasmic Dynein Intermediate Chain

The TGFβ Receptor-interacting Protein km23-1/DYNLRB1 Plays an Adaptor Role in TGFβ1 Autoinduction via Its Association with Ras

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