Identification of two novel avian influenza a (H5N6) viruses in wild birds, Shanghai, in 2016

He, Guimei; Zhou, Linan; Zhu, Chengshen; Shi, Hongliang; Li, Xiaofang; Wu, Di; Jing, Liu; Lv, Jiamin; Hu, Chuanxia; Li, Zhihui; Wang, Zhenghuan

doi:10.1016/j.vetmic.2017.07.017

Cited by 9 publications

(9 citation statements)

References 14 publications

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“…The increased awareness that wild birds are the natural hosts of AIVs [ 28 ] has promoted monitoring of AIVs in wild birds. Shanghai is one of the overwintering and stopover sites along the East Asian–Australasian migration route for wild birds [ 20 , 21 ]. Each year, millions of migratory birds of various species pass through Shanghai.…”

Section: Discussionmentioning

confidence: 99%

“…Waterfowl play an important role in AIV transmission because AIVs in the feces of infected birds are excreted into water and can be transmitted by migratory birds to other birds and mammals [ 18 , 19 ]. Shanghai is a city in the Yangtze River Estuary in the East Asian–Australasian Flyway and is an important stopover and wintering site for migratory birds [ 20 , 21 ]. During our routine surveillance of wild birds in 2016–2019, we detected a small number of H10–H12 subtypes of AIV in this region.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Avian Influenza Virus H10–H12 Subtypes Isolated from Wild Birds in Shanghai, China from 2016 to 2019

Tang

Ming

et al. 2020

Viruses

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H10, H11 and H12 (H10–H12) subtypes of the avian influenza virus (AIV) are associated with waterfowl. Although these subtypes of AIV are infrequently detected in nature, they can undergo reassortment with other AIV subtypes. Few H10–H12 subtypes of AIV have been isolated from wild birds in China. In this study, 12 AIV isolates of H10–H12 subtypes were identified via routine surveillance of wild birds in Shanghai, China from 2016 to 2019, including two H10, three H11 and seven H12 isolates. Sequence and phylogenetic analyses revealed that the genomic segments of the 12 isolates are highly diverse. These 12 isolates are closely related to those in the Eurasian lineage and share a high degree of sequence identity with those from wild birds and domestic ducks in countries in the East Asian–Australasian Flyway, including Japan, Korea, Bangladesh, Vietnam and China. However, parts of the genomic segments of two H12N2 isolates (NH112319-H12N2 and NH101807-H12N2) belong to the North American lineage, suggesting intercontinental reassortment among H12 AIVs in Eurasia and North American. To better understand the ecological and phylodynamic features of H10–H12 subtypes in wild birds, a large-scale surveillance of AIVs in wild birds is warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of Avian Influenza Virus H10–H12 Subtypes Isolated from Wild Birds in Shanghai, China from 2016 to 2019

Tang

Ming

et al. 2020

Viruses

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“…H5N3 viruses were first detected in South Africa in 1959 and are endemic in aquatic birds, especially wild and domestic ducks. Several subtypes including H5N1, H5N2, H5N6, H5N7 and H5N8 have been detected in wild and domestic aquatic birds, and co‐infections are a potential threat to the poultry industry and public health (Chen et al, ; El‐Shesheny et al, ; He et al, ; Jimenez‐Bluhm et al, ; Lee, Torchetti, Killian, DeLiberto, & Swayne, ; Liu et al, ; Ma et al, ).…”

Section: Introductionmentioning

confidence: 99%

Characterization of avian influenza H5N3 reassortants isolated from migratory waterfowl and domestic ducks in China from 2015 to 2018

Cui

Zeng

et al. 2019

Transbound Emerg Dis

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Wild and domestic aquatic birds are the natural reservoirs of avian influenza viruses (AIVs). All subtypes of AIVs, including 16 hemagglutinin (HA) and nine neuraminidase (NA), have been isolated from the waterfowls. The H5 viruses in wild birds display distinct biological differences from their highly pathogenic H5 counterparts. Here, we isolated seven H5N3 AIVs including three from wild birds and four from domestic ducks in China from 2015 to 2018. The isolation sites of all the seven viruses were located in the region of the East Asian‐Australasian Migratory Flyway. Phylogenetic analysis indicated that the surface genes of these viruses originated from the wild bird H5 HA subtype and the N3 Eurasian lineage. The internal genes of the seven H5N3 isolates are derived from the five gene donors isolated from the wild birds or ducks in Eastern‐Asia region. They were also divided into five genotypes according to their surface genes and internal gene combinations. Interestingly, two of the seven H5N3 viruses contributed their partial internal gene segments (PB1, M and NS) to the newly emerged H7N4 reassortants, which have caused first human H7N4 infection in China in 2018. Moreover, we found that the H5N3 virus used in this study react with the anti‐serum of the H5 subtype vaccine isolate (Re‐11 and Re‐12) and reacted well with the Re‐12 anti‐serum. Our findings suggest that worldwide intensive surveillance and the H5 vaccination (Re‐11 and Re‐12) in domestic ducks are needed to monitor the emergence of novel H5N3 reassortants in wild birds and domestic ducks and to prevent H5N3 viruses transmission from the apparently healthy wild birds and domestic ducks to chickens.

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“…Furthermore, for some representative subtypes detected in this study, genetic analyses have been performed in our previous published manuscripts, such as H5N6 viruses [19], H8N4 virus [24], H6 subtypes [25], H7 and H8-H12 subtypes (data not shown). From these analyses, we found that most of these strains were all clustered in the Eurasian lineage, but there were also a few gene segments belonging to the North American lineage.…”

Section: Species Differencesmentioning

confidence: 99%

Avian Influenza Virus Prevalence and Subtype Diversity in Wild Birds in Shanghai, China, 2016–2018

Tang

et al. 2020

Viruses

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From 2016 to 2018, surveillance of influenza A viruses in wild birds was conducted in Shanghai, located at the East Asian–Australian flyway, China. A total of 5112 samples from 51 species of wild birds were collected from three different wetlands. The total three-year prevalence of influenza A viruses among them was 8.8%, as assessed using real-time polymerase chain reaction (PCR) methods, and the total prevalence was higher in Anseriformes (26.3%) than in the Charadriiformes (2.3%) and the other orders (2.4%) in the Chongmin wetlands. Anseriformes should be the key monitoring group in future surveillance efforts. The peak prevalence of influenza A viruses in Charadriiformes were in April and September, and in other bird orders, the peaks were in November and December. Twelve subtypes of haemagglutinin (HA; H1–H12) and eight subtypes of neuraminidase (NA; N1, N2, N4–N9) were identified in 21 different combinations. The greatest subtype diversity could be found in common teal, suggesting that this species of the bird might play an important role in the ecology and epidemiology of influenza A viruses in Shanghai. These results will increase our understanding of the ecology and epidemiology of influenza A viruses in wild bird hosts in eastern China, and provide references for subsequent surveillance of influenza A virus in wild birds in this area.

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Identification of two novel avian influenza a (H5N6) viruses in wild birds, Shanghai, in 2016

Cited by 9 publications

References 14 publications

Characterization of Avian Influenza Virus H10–H12 Subtypes Isolated from Wild Birds in Shanghai, China from 2016 to 2019

Characterization of Avian Influenza Virus H10–H12 Subtypes Isolated from Wild Birds in Shanghai, China from 2016 to 2019

Characterization of avian influenza H5N3 reassortants isolated from migratory waterfowl and domestic ducks in China from 2015 to 2018

Avian Influenza Virus Prevalence and Subtype Diversity in Wild Birds in Shanghai, China, 2016–2018

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