Identification of two herbal compounds with potential cholesterol-lowering activity

Zhang, Yilin; Zhang, Haiqing; Hua, Shineng; Ma, Lianghui; Chen, Cong; Liu, Xiaoyu; Jiang, Liqun; Yang, Huanming; Zhang, Pei‐Cheng; Yu, Daoyong; Guo, Yinlong; Tan, Xuehai; Liu, Jianfeng

doi:10.1016/j.bcp.2007.06.020

Cited by 15 publications

(12 citation statements)

References 31 publications

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“…Various biological activities were also reported for Daphne species including analgesic, anti-inflammatory, antioxidant, anticancerogenic, antimicrobial, anti-ulcerogenic, abortive, hypocholesterolemic and hemostatic (Murakami et al, 1992;Cottiglia et al, 2001;Hong et al, 2002;Deiana et al, 2003;Kupeli et al, 2007;Zhang et al, 2007;Zheng et al, 2007;Lee et al, 2009).…”

Section: Introductionmentioning

confidence: 93%

Efficacy of Daphne oleoides subsp. kurdica used for wound healing: Identification of active compounds through bioassay guided isolation technique

Süntar

Akkol

Keleş

et al. 2012

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 93%

Efficacy of Daphne oleoides subsp. kurdica used for wound healing: Identification of active compounds through bioassay guided isolation technique

Süntar

Akkol

Keleş

et al. 2012

Journal of Ethnopharmacology

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“…Bahadori et al (2013) suggested that there were not significant effects of Dill seeds on cholesterol and serum blood highdensity lipoprotein levels in broilers. It has been argued that dill has dose-dependent cholesterol-lowering effects (Zhang et al, 2007). They also showed that birds fed by Dill seeds showed significantly (P<0.05) lower very low-density lipoprotein and triglyceride serum compared to control group.…”

Section: Resultsmentioning

confidence: 95%

Effect of using different levels of Dill seeds on performance, some blood biochemical and intestinal microbial population in Ross 308 broiler chicks

Rahimian¹,

Kheiri²,

Alavi³

et al. 2017

J. Herbal Drugs

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Background & Aim: Dill "Anethum graveolens" is an annual medical plantin the celery family "Apiaceae". It is the sole species of the genus "Anethum".The health advantages of dill seed include its ability to increasedigestive health, as well as providingrelief from insomnia, hiccups, diarrhea, dysentery, menstrual disorders, respiratory disorders, and cancer. This experiment aimed to determine the effects of using different levels of Dill seeds on performance, some blood biochemical parameters and intestinal microbial population in Ross 308 broiler chicks. Experimental: 300 one-day-old male broiler chickswere divided into the four treatments with six replicates and 15 birds each as randomized design. The treatments contained basal diet with no Dill seeds kept as control, and200,400 and 600 gof Dill seedsper each ton of diets respectively. The live bodyweightsgain, feed intake and feed conversion ratio of birdswere calculated weekly. At the end of the experimentfour male birdsform each replicates were slaughtered and dressing percentage were calculated. In addition, some carcass traits and chick's visceral partwere weighed separately as percentage of carcass and some organs weight. Results: Data indicated that using Dill seeds increased feed intake (FI) in treatmentscompared to control.Alsobody weight (BW) (g/d) and Preslaughter weight (g) were higher in groups that werefed by dill seedscompared to the control. Additionally, therewere significant differences (p<0.05) for feed conversation ratio (FCR) among treatments.

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“…While Ginkgo biloba triggers a PKC-independent modification of -secretases expression [206], green teaepigallocatechin-3-gallate seems to specifically activate ProADAM10 maturation and concomitantly presents the valuable advantage of inhibiting A -dependent BACE1 upregulation [207]. Because increased LDL-cholesterol is a well-established risk factor for AD, atherosclerosis and the underlying cause of coronary heart diseases and strokes, natural cholesterol-lowering agents such as the two herbal compounds (daphnetoxin and gniditrin) extracted from Chinese herb Daphne giraldii Nitschewith [208] are expected to very likely display beneficial effects toward distinct severe pathologies. It has also been shown that pore-perforing bacterial toxin streptolysin O (SLO) invokes a rapid and robust shedding of IL6 receptor and L-selectin [209,210].…”

Section: Natural Compoundsmentioning

confidence: 99%

α-Secretase in Alzheimers Disease and Beyond: Mechanistic, Regulation and Function in the Shedding of Membrane Proteins

Vincent¹,

Checler

2012

CAR

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Proteases regulate numerous physiological functions in all living organisms. Because of their contribution to βAPP processing, α-, β- and γ-secretases have focused particular attention of researchers in the field of Alzheimer's disease (AD) during the past 20 years. Whereas the β-secretase BACE1 and the heterotetrameric presenilin-dependent γ- secretase complex were identified between 1995 and 2002, α-secretase activity was attributed to previously described ADAM10 and ADAM17, two members of the type I integral membrane protein family called ADAMs (A Disintegrin And Metalloprotease). ADAM10 and/or ADAM17 target numerous substrates through various modes of action. This review focuses on the complex physiology of these α-secretases and will document their contribution to cancers, diabetes, rheumatoid arthritis, and prion diseases besides their well characterized role in Alzheimer's disease.

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Identification of two herbal compounds with potential cholesterol-lowering activity

Cited by 15 publications

References 31 publications

Efficacy of Daphne oleoides subsp. kurdica used for wound healing: Identification of active compounds through bioassay guided isolation technique

Efficacy of Daphne oleoides subsp. kurdica used for wound healing: Identification of active compounds through bioassay guided isolation technique

Effect of using different levels of Dill seeds on performance, some blood biochemical and intestinal microbial population in Ross 308 broiler chicks

α-Secretase in Alzheimers Disease and Beyond: Mechanistic, Regulation and Function in the Shedding of Membrane Proteins

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Identification of two herbal compounds with potential cholesterol-lowering activity

Cited by 15 publications

References 31 publications

Efficacy of Daphne oleoides subsp. kurdica used for wound healing: Identification of active compounds through bioassay guided isolation technique

Efficacy of Daphne oleoides subsp. kurdica used for wound healing: Identification of active compounds through bioassay guided isolation technique

Effect of using different levels of Dill seeds on performance, some blood biochemical and intestinal microbial population in Ross 308 broiler chicks

&#945;-Secretase in Alzheimers Disease and Beyond: Mechanistic, Regulation and Function in the Shedding of Membrane Proteins

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α-Secretase in Alzheimers Disease and Beyond: Mechanistic, Regulation and Function in the Shedding of Membrane Proteins