Identification of the three predominant prostatic-secreted proteins and their immunohistochemical localization in normal, hyperplastic and neoplastic prostatic tissue

Pa, Abrahamsson; Lilja, Hans; Falkmer, S; Wadström, Lars B.

doi:10.1016/0277-5379(87)90163-5

Cited by 2 publications

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“…Although presence of inhibin in the prostate was first demonstrated by immunoassay in 1981 and later confirmed by bioassay (Kharbanda -1985) and immunohistochemical technique (Doctor et al -1987;Abrahamson et al -1987) prostate was considered as a repository of inhibin rather than a tissue responsible for its synthesis. This was partly guided by (i) the presumption that testis is the only source of inhibin (ii) presence of specific receptors for inhibin in the prostate (Phadke et al -1982) and (iii) lack of knowledge of any biosynthetic mechanism.…”

Section: Discussionmentioning

confidence: 99%

Hormonal modulation of Invitro Biosynthesis of Inhibin like Peptide by Human Prostate: Hormonelle Modulation der In-vitro-Biosynthese des Inhibin-ähnlichen Peptids durch die menschliche Prostata

et al. 2009

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Summary: The hormonal regulation of inhibin biosynthesis by human benign hyperplastic prostate tissue was studied by determining the incorporation of 3H‐leucine. 3H‐inhibin, synthesized de novo, was immunoprecipitated from the culture media using specific antibodies to human prostatic inhibin. Testosterone and estradiol had no effect on inhibin biosynthesis whereas hFSH and PMSG had stimulatory effect. A decrease in inhibin biosynthesis was noticed on the addition of LHRH, TRH, hCG, hLH and human prolactin. Zusammenfassung: Mittels des Einbaues von 3H‐Leucin wurde die hormonelle Regulation der Inhibin‐Biosynthese durch menschliches Gewebe von benigner hyperplastischer Prostata untersucht. 3H‐Inhibin wurde immunpraecipitiert von den Kulturmedien unter Verwendung von spezifischen Antikörpern gegen menschliches Prostata‐Inhibin. Testosteron und Oestradiol hatten keinen Einfluß auf die Inhibin‐Biosynthese, während humanes FSH und PMSG einen stimulierenden Effekt besaßen. Ein Rückgang der Inhibin‐Biosynthese konnte beobachtet werden nach Zusatz von LH‐RH, hCG, hLH und menschlichem Prolaktin.

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Section: Discussionmentioning

confidence: 99%