Identification of the significant pathways of Banxia Houpu decoction in the treatment of depression based on network pharmacology

Chen, Ziying; Xie, Danfeng; Liu, Zhiyuan; Zhong, Yongqi; Zeng, Jingyan; Chen, Zheng; Chen, Xinlin

doi:10.1371/journal.pone.0239843

Cited by 8 publications

(4 citation statements)

References 74 publications

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“…Although the exact mechanism of action of Banxia Houpu Decoction has not been fully elucidated, network pharmacology analysis has identified several major pathways and targets, including the MAPK pathway, HIF pathway, PI3K pathway, calcium signaling pathway, and neural ligand-receptor interaction. [ 24 ] The active ingredients in Banxia Houpu Decoction, such as Pinellia alkaloids, can act on the 5-HT pathway to regulate smooth muscle tone, [ 25 ] while magnolia phenols in houpo can act on G proteins to regulate calcium ion influx and increase sphincter tone. [ 26 , 27 ] Perilla aldehyde in size can reduce the levels of inflammatory cytokines such as IL-1β, IL-6, and TNF-α.…”

Section: Discussionmentioning

confidence: 99%

Efficacy evaluation and exploratory analysis of influencing factors of Banxia Houpu Decoction in the treatment of refractory gastroesophageal reflux disease

Song,

Zhang,

Zhang

et al. 2024

Medicine

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Approximately 10% to 40% of patients with gastroesophageal reflux disease (GERD) exhibit poor response to proton pump inhibitors (PPIs), indicating refractory GERD (RGERD). Banxia Houpu Decoction is a traditional Chinese medicine formula used for treating GERD, particularly for atypical symptoms. This study aimed to investigate the improvement of different symptoms in RGERD patients treated with Banxia Houpu Decoction and identify relevant factors influencing its efficacy. From November 2021 to November 2022, a total of 89 RGERD patients voluntarily participated in this clinical study at our hospital. They were randomly assigned to 2 treatment groups: the Banxia Houpu Decoction group and the Western medicine group. The former received standard-dose Banxia Houpu Decoction, while the latter had a switch in PPI type with double-dose maintenance and the addition of magnesium aluminum carbonate as an acid suppressant. The improvement of different symptoms was compared between the 2 groups. Clinical data, including age, gender, gastric mucosal status, and esophagitis severity, were collected. Univariate analysis was performed to explore factors influencing the therapeutic effect of Banxia Houpu Decoction. Both treatment groups showed significant improvement in Frequency Scale for the Symptoms of GERD (FSSG) scores. The Banxia Houpu Decoction group exhibited the most significant efficacy in relieving throat burning sensation (P = .003) and frequent hiccups (P = .003). It also demonstrated improvement in swallowing difficulty (P = .048) and postprandial abdominal distension (P = .041), surpassing the Western medicine group. The Western medicine group had the most significant improvement in heartburn sensation (P = .008) and showed significant improvement in gastric burning sensation (P = .022), surpassing Banxia Houpu Decoction. Age (P = .025) and gastroesophageal flap valve (GEFV) grade (P = .014) were identified as factors influencing the efficacy of Banxia Houpu Decoction. Banxia Houpu Decoction exhibits superior efficacy compared to double-dose PPI combined with acid suppressants in relieving symptoms such as throat burning sensation, swallowing difficulty, and frequent hiccups. It shows significant efficacy in patients under 60 years of age and with GEFV grades I-II.

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Section: Discussionmentioning

confidence: 99%

Efficacy evaluation and exploratory analysis of influencing factors of Banxia Houpu Decoction in the treatment of refractory gastroesophageal reflux disease

Song,

Zhang,

Zhang

et al. 2024

Medicine

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“…2C). After ltering the highest 30% -betweenness centrality (BC) 30 of subnetwork, the key network was established, containing 26 nodes, and 248 edges (Table S4, Fig. 2D).…”

Section: Ppi Networkmentioning

confidence: 99%

A panorama to mine “bioactive X” against progressive deterioration of liver disease: from NAFLD to HCC

Oh,

Yoon,

Eom

et al. 2023

Preprint

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Non-alcoholic fatty liver disease (NAFLD) is implicated in steatohepatitis (NASH), liver cirrhosis (LC) to hepatocellular carcinoma (HCC), sequentially. Herein, our aim was to unravel the nuanced key components (compounds, and targets) to deter the progressive severity concerning hepatocellular diseases. We incorporated rigor bioinformatics and computational screening tools to decode effector(s) against NAFLD, NASH, LC, and HCC. The targets of the four hepatic-diseases were browsed by DisGeNET and OMIM, then, the intersecting targets were identified by Venn diagram. Protein-protein interaction (PPI) networks were constructed on STRING database with the aid of R program. The uppermost target(s) against NAFLD, NASH, LC, and HCC were filtered by degree centrality (DC), and betweenness centrality (BC) value. We utilized the Selleckchem (compound repository website) to retrieve the ligand(s) for the target(s), hereby, confirmed the affinity via molecular docking test (MDT), density functional theory (DFT), and toxicity prediction. The final targets (295) were identified by DisGeNET and OMIM, the core PPI networks comprised 26 nodes, and 248 edges with two key targets (INS, and IL6) in the highest 30% betweenness centrality (BC). The corresponding ligands of PDX1 (transcription factor of INS; one agonist), and IL6 (thirty-two antagonists) were identified by Selleckchem. Molecular docking test (MDT) revealed that PDX1- BRD7552 conformer (-12.1 kcal/mol), and IL6- Forsythoside B (-11.4 kcal/mol) conformer formed most stable complex. In parallel, DFT proposed that BRD7552, and Forsythoside B had significant chemical properties to react the targets, respectively. In conclusion, we decoded causatives of the progressive liver disease with web-based tools in drug repositioning theory. BRD7552 as PDX1 agonist, and Forsythoside B as IL6 antagonist were attributed to synergistic efficacy against NAFLD-derived HCC.

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“… 2017 ; Chen et al. 2020 ) and chronic obstructive pulmonary disease (Li and Bai 2019 ). In addition to adjusting lipid metabolism disorders and endothelial damage in OSA patients, clinical studies have also illustrated that BHD could significantly improve the severity of OSA through the ‘Phlegm-Qi’ interaction (Fang et al.…”

Section: Introductionmentioning

confidence: 99%

Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia

Song

Zhao

Zhen

et al. 2022

Pharmaceutical Biology

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Context Obstructive sleep apnoea (OSA) causes chronic intermittent hypoxia (CIH), which results in mitochondrial dysfunction and generates reactive oxygen species (ROS) in the heart. Excessive free iron could accelerate oxidative damage, which may be involved in this process. Banxia-Houpu decoction (BHD) was reported to improve the apnoea hypopnoea index in OSA patients, but the specific mechanism was still unclear. Objective To investigate whether BHD could reduce CIH-induced heart damage by regulating iron metabolism and mitochondrial function. Materials and methods C57BL/6N mice were randomly divided into control, CIH and BHD groups. Mice were exposed to CIH (21 − 5% O 2 , 20 times/h, 8 h/d) and administered BHD (3.51, 7.01 and 14.02 g/kg, intragastrically) for 21 d. Cardiac and mitochondrial function, iron levels, apoptosis and mitophagy were determined. Results BHD (7.01 g/kg) significantly improved cardiac dysfunction, pathological change and mitochondrial structure induced by CIH. BHD increased the Bcl-2/Bax ratio (1.4-fold) and inhibited caspase 3 cleavage in CIH mice (0.45-fold). BHD activated mitophagy by upregulating Parkin (1.94-fold) and PINK1 (1.26-fold), inhibiting the PI3K-AKT-mTOR pathway. BHD suppressed ROS generation by decreasing NOX2 (0.59-fold) and 4-HNE (0.83-fold). BHD reduced the total iron in myocardial cells (0.72-fold) and mitochondrial iron by downregulating Mfrn2 (0.81-fold) and MtFt (0.78-fold) proteins, and upregulating ABCB8 protein (1.33-fold). Rosmarinic acid, the main component of Perilla Leaf in BHD, was able to react with Fe 2+ and Fe 3+ in vitro . Discussion and conclusions These findings encourage the use of BHD to resist cardiovascular injury and provide the theoretical basis for clinical treatment in OSA patients.

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Identification of the significant pathways of Banxia Houpu decoction in the treatment of depression based on network pharmacology

Cited by 8 publications

References 74 publications

Efficacy evaluation and exploratory analysis of influencing factors of Banxia Houpu Decoction in the treatment of refractory gastroesophageal reflux disease

Efficacy evaluation and exploratory analysis of influencing factors of Banxia Houpu Decoction in the treatment of refractory gastroesophageal reflux disease

A panorama to mine “bioactive X” against progressive deterioration of liver disease: from NAFLD to HCC

Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia

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