Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia

Song, Ji-Xian; Zhao, Ya-Shuo; Zhen, Ya-Qin; Yang, Xiongwen; Chen, Qi; An, Ji-Ren; Ji, En-Sheng

doi:10.1080/13880209.2022.2043392

Cited by 19 publications

(23 citation statements)

References 51 publications

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“… 53 Intrahippocampal iron causes toxic effects and cognitive dysfunction manifested by the damage of dendritic structure and downregulation of synapse-related proteins, including BDNF, SYP, PSD95, and tenascin C. 54 At the same time, excess iron could accelerate mitochondrial oxidative damage caused by CIH. 16 , 34 …”

Section: Discussionmentioning

confidence: 99%

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Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia

Yang¹,

Geng²,

Li³

et al. 2023

IJN

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Background Chronic intermittent hypoxia (CIH) could cause neuronal damage, accelerating the progression of dementia. However, safe and effective therapeutic drugs and delivery are needed for successful CIH therapy. Purpose To investigate the neuroprotective effect of Huperzine A (HuA) packaged with nanoliposomes (HuA-LIP) on neuronal damage induced by CIH. Methods The stability and release of HuA-LIP in vitro were identified. Mice were randomly divided into the Control, CIH, HuA-LIP, and HuA groups. The mice in the HuA and HuA-LIP groups received HuA (0.1 mg/kg, i.p.), and HuA-LIP was administered during CIH exposure for 21 days. HuA-LIP contains the equivalent content of HuA. Results We prepared a novel formulation of HuA-LIP that had good stability and controlled release. First, HuA-LIP significantly ameliorated cognitive dysfunction and neuronal damage in CIH mice. Second, HuA-LIP elevated T-SOD and GSH-Px abilities and decreased MDA content to resist oxidative stress damage induced by CIH. Furthermore, HuA-LIP reduced brain iron levels by downregulating TfR1, hepcidin, and FTL expression. In addition, HuA-LIP activated the PKAα/Erk/CREB/BDNF signaling pathway and elevated MAP2, PSD95, and synaptophysin to improve synaptic plasticity. Most importantly, compared with HuA, HuA-LIP showed a superior performance against neuronal damage induced by CIH. Conclusion HuA-LIP has a good sustained-release effect and targeting ability and efficiently protects against neural injury caused by CIH.

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Section: Discussionmentioning

confidence: 99%

“…Analysis of interaction with iron ions was carried out as previously described. 34 HuA, dissolved in methanol, reacted with Fe 2+ and Fe 3+ solutions in acetic acid-sodium acetate (HAc-NAc) buffer. Then HuA and mixture were simultaneously detected via full wavelength scanning.…”

Section: Methodsmentioning

confidence: 99%

Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia

Yang¹,

Geng²,

Li³

et al. 2023

IJN

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“…HKT improved CIH‐induced cardiac dysfunction and histological changes, attenuated mitochondrial damage and apoptosis, and activated mitophagy to resist cardiac injury. In addition, HKT suppressed ROS generation in cardiac tissue and reduced CIH‐induced iron deposits in the mitochondria [61].…”

Section: Kampo Extract Formulation Administration Amount and Duration...mentioning

confidence: 99%

A review of frequently used Kampo prescriptions: Part 2—Hangekobokuto

Suzuki

Kikuchi

Arita

et al. 2023

Traditional & Kampo Medicine

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BackgroundThe origin of hangekobokuto (HKT) is from Jin Gui Yao Lue (Kinkiyōryaku in Japanese), and it has been indicated for treating throat discomfort in women.Key FindingsHKT consists of five crude drugs. Clinical studies have shown that HKT can improve the swallowing reflex by increasing the substance P level in saliva; improve the cough reflex; reduce pneumonia in patients with dementia, cerebrovascular disease, Alzheimer's disease, or Parkinson's disease; reduce postoperative aspiration pneumonia in patients who undergo cardiovascular surgery; and improve depression and anxiety scores in patients with globus hystericus. Furthermore, HKT has been reported to increase serotonin (5‐HT) and noradrenaline levels in the hypothalamus, and dopamine (DA) levels in the striatum in a healthy rodent model; improve 5‐HT levels in the striatum and hippocampus, and ameliorate 5‐HT and DA reductions in the whole brain in an acute stress model; improve 5‐HT levels in the striatum, and ameliorate 5‐HT and DA reductions in the prefrontal cortex in a chronic stress model; and decrease corticosterone and corticotropin‐releasing factor levels in a chronic stress model. Reported adverse events of HKT include interstitial pneumonia (0.38 per 100 000 cases) and liver damage (0.89 per 100 000 cases), which are rare.ConclusionHKT is widely used and shows a low rate of adverse events. Several clinical studies have reported its effects in reducing aspiration pneumonia and improving depression and anxiety, some of which may be explained by the regulation of monoamines and stress hormones in the brain and substance P levels in the oral cavity.

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“…Chronic intermittent hypoxia (CIH) is the most deleterious feature of OSA, as it can lead to oxidative damage in every organ ( Shan et al, 2007 ). CIH can suppress mitochondrial function and lead to the generation of reactive oxygen species (ROS) ( Wang et al, 2010 ; Huang et al, 2014 ; Zhao et al, 2019 ; Lin et al, 2021 ; Song et al, 2022 ). As mitochondrial status is important for the metabolic function of all organs, mitochondrial dysfunction at the cellular level that can affect systemic metabolic balance can significantly contribute to many diseases and have been defined as classical a hallmark of many diseases ( Srinivasan et al, 2017 ; Chapman et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…Second, mitochondrial DNA (mtDNA) copy number is significantly reduced in patients with OSA, and it is a reliable biomarker for predicting cardiovascular risk in patients with OSA ( Kim et al, 2014 ). Third, Banxia-Houpu decoction reduced CIH-induced heart damage by regulating mitochondrial function ( Song et al, 2022 ). Fourth, attenuating mitochondria-dependent apoptosis has been suggested as a novel adjunct strategy for ameliorating OSA-induced neurocognitive impairment ( Xu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Construction of a mitochondrial dysfunction related signature of diagnosed model to obstructive sleep apnea

Liu

Hao²,

Li³

et al. 2022

Front. Genet.

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Background: The molecular mechanisms underlying obstructive sleep apnea (OSA) and its comorbidities may involve mitochondrial dysfunction. However, very little is known about the relationships between mitochondrial dysfunction-related genes and OSA.Methods: Mitochondrial dysfunction-related differentially expressed genes (DEGs) between OSA and control adipose tissue samples were identified using data from the Gene Expression Omnibus database and information on mitochondrial dysfunction-related genes from the GeneCards database. A mitochondrial dysfunction-related signature of diagnostic model was established using least absolute shrinkage and selection operator Cox regression and then verified. Additionally, consensus clustering algorithms were used to conduct an unsupervised cluster analysis. A protein–protein interaction network of the DEGs between the mitochondrial dysfunction-related clusters was constructed using STRING database and the hub genes were identified. Functional analyses, including Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, gene set enrichment analysis (GSEA), and gene set variation analysis (GSVA), were conducted to explore the mechanisms involved in mitochondrial dysfunction in OSA. Immune cell infiltration analyses were conducted using CIBERSORT and single-sample GSEA (ssGSEA).Results: we established mitochondrial dysfunction related four-gene signature of diagnostic model consisted of NPR3, PDIA3, SLPI, ERAP2, and which could easily distinguish between OSA patients and controls. In addition, based on mitochondrial dysfunction-related gene expression, we identified two clusters among all the samples and three clusters among the OSA samples. A total of 10 hub genes were selected from the PPI network of DEGs between the two mitochondrial dysfunction-related clusters. There were correlations between the 10 hub genes and the 4 diagnostic genes. Enrichment analyses suggested that autophagy, inflammation pathways, and immune pathways are crucial in mitochondrial dysfunction in OSA. Plasma cells and M0 and M1 macrophages were significantly different between the OSA and control samples, while several immune cell types, especially T cells (γ/δ T cells, natural killer T cells, regulatory T cells, and type 17 T helper cells), were significantly different among mitochondrial dysfunction-related clusters of OSA samples.Conclusion: A novel mitochondrial dysfunction-related four-gen signature of diagnostic model was built. The genes are potential biomarkers for OSA and may play important roles in the development of OSA complications.

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Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia

Cited by 19 publications

References 51 publications

Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia

Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia

A review of frequently used Kampo prescriptions: Part 2—Hangekobokuto

Construction of a mitochondrial dysfunction related signature of diagnosed model to obstructive sleep apnea

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