Identification of the novel HLA‐DQB1*06:209 allele in a Chinese individual

Abstract

HLA-DQB1*06:209 has one nucleotide change from HLA-DQB1*06:01:01 at position 260 G>C in exon 2.

Characterization of the novel HLA‐A*31:01:34 allele by polymerase chain reaction sequencing‐based typing

“…According to the guidelines for HLA genotyping at the CMDP, the HLA genotype of the donors must be determined using molecular techniques. During this project, many HLA novel alleles have been identified in the Chinese donors 1‐3 . Here, we describe the novel allele, now named HLA‐A*31:01:34 , that was found in a CMDP donor.…”

Identification of the novel HLA‐DQB1*06:466 allele by next‐generation sequencing in a Chinese cord blood donor

“…Currently, more than 38,008 HLA alleles have been identified in the populations around the world according to the IPD‐IMGT/HLA Database release 3.55 version, including 2510 HLA‐DQB1 alleles 1 . We also reported more than 200 novel alleles during the routine HLA genotyping for the patients and donors 2,3 . Here, we present the novel HLA‐DQB1*06:466 allele, that has been identified in a Chinese cord blood donor.…”

“…1 We also reported more than 200 novel alleles during the routine HLA genotyping for the patients and donors. 2,3 Here, we present the novel HLA-DQB1*06:466 allele, that has been identified in a Chinese cord blood donor. The sample was originally genotyped for HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 loci using the AllType™ NGS 11-loci amplification kit (One Lambda Inc., Canoga Park, CA, USA) and the genotype of the sample was assigned with TypeStream Visual Software version 2.0 (One Lambda Inc.) as previously reported.…”