Identification of the N-Acetylcysteine Sensitive Receptor Endoglin in Hepatic Stellate Cells

Meurer, SK; Tihaa, Lidia; Lahme, Birgit; Gressner, A. M.; Weiskirchen, Ralf

doi:10.1055/s-2005-861596

Cited by 1 publication

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“…Besides, Meurer et al (2005) demonstrated that NAC blocked the receptor binding of TGF-β1 and prevent fibronectin creation from stopping irregular cellular remodeling. This support our finding concerning the α-smooth muscle actin (α-SMA) in which NAC reversed the TGF-β1-stimulated α -SMA expression (Meurer et al, 2005) also, Kopp et al (2006) proposed that NAC repeals TGFβ1 signaling and consequent fibrogenesis adjective of proteins related with Dupuytren's disease. Our finding revealed that GA3 treated group shows a significant increase of TNFα and NFkB, this result was in agreement with (Khalaf et al, 2019).…”

Section: Discussionmentioning

confidence: 98%

Impacts of n‐acetyl cysteine on gibberellic acid‐induced hepatorenal dysfunction through modulation of pro‐inflammatory cytokines, antifibrotic and antioxidant activity

et al. 2021

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The extensive usage of gibberellic acid (GA3) in agriculture and plant growth is generally associated with enormous human and public health hazards. The present research assesses the impact of n-acetyl cysteine (NAC) on the hepatorenal injury persuaded by GA3 for this purpose, After two weeks of adaptation twenty-four rats allocated into four groups (6 rats/group) as follows: control group, supplied with saline only; n-acetyl cysteine (NAC) group, provided with 150 mg/kg/bw by stomach tube (orally) dissolved in saline; Positive GA3 group, received GA3 (55 mg/kg/bw) orally; Protective group received NAC (150 mg/kg/bw) and GA3 (55 mg/kg/bw) as in NAC and GA3 groups. Rats received their treatments for consecutive 3 weeks.On day 22, rats were anesthetized, then euthanized. Blood and tissue samples were obtained for biochemical, antioxidants markers analysis, gene expression, and histopathological examination. Our results revealed significant changes in serum AST, ALT, urea, uric acid, total protein, and albumin levels with a substantial rise of MDA and NO concentration in GA3 treated rats along with a considerable decrease of the GSH and overexpression of the inflammatory hepatic and renal cytokines (IL-10, TNFα, NOS) and fibrotic gene expression TGF-β1, and α-SMA, with boost expression of nuclear factor-kappa (NF k B). NAC co-administered with GA3 significantly normalized the kidney and liver function and the antioxidant state, besides normal histological structure of both liver and kidney tissue and downregulated expression of the proinflammatory cytokines as well as, fibrogenic gene expression. How to cite this article: Soliman MM, Aldhahrani A, Gaber A, et al. Impacts of n-acetyl cysteine on gibberellic acid-induced hepatorenal dysfunction through modulation of proinflammatory cytokines, antifibrotic and antioxidant activity. J

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