Identification of the CCR5-Δ32 HIV resistance allele and new mutations of the CCR5 gene in different Tunisian populations

Determination of the CCR5∆32 frequency in Emiratis and Tunisians and the screening of the CCR5 gene for novel alleles in Emiratis

“…The group from Tunisia noticed high frequency of the L55Q variant among individuals of Berber origin (Jlizi et al, 2007). The highest frequency of 0.21 was observed in the Berber of Chenini-Douriet (38.46%) followed by a frequency of 0.07 in the Berber of Sajnene (14.28%, Table 3) (Jlizi et al, 2007). The L55Q variant was associated with C101X polymorphism in the same haplotype in the studied Tunisian samples.…”

“…The L55Q variant was associated with C101X polymorphism in the same haplotype in the studied Tunisian samples. Moreover, Jlizi and research group have noticed that the frequency of L55Q polymorphism was higher in HIV affected group compared to healthy people, however the difference was not significant (Jlizi et al, 2007).…”

“…However, it was absent among African and East Asian individuals (Table 3). Studies have shown that the percentages of L55Q polymorphism were found to be 7.8%, 3-4% and 2.7% among Tunisians, Caucasians and Euro-Brazilians, respectively (Table 3) (Boldt et al, 2009;Carrington et al, 1999;Jlizi et al, 2007). The group from Tunisia noticed high frequency of the L55Q variant among individuals of Berber origin (Jlizi et al, 2007).…”

“…The frequency of the CCR5Δ32 mutant is at the brink of significance between both studied groups (p = 0.06, Table 1), this might be due to (i) the difference in size samples (253/150) and (ii) wide genetic differences. For the Tunisian population, Barbouche et al (2001) have shown that the frequency of the CCR5Δ32 allele was 0.01 (3/145) in healthy Tunisian control samples, though another group demonstrated that its frequency was 0.034 (205 control samples) (Jlizi et al, 2007). Therefore, for the Tunisian population the frequency ranges between 0.01 and 0.034, giving a mean of 0.02.…”

“…Studies have shown that the percentages of L55Q polymorphism were found to be 7.8%, 3-4% and 2.7% among Tunisians, Caucasians and Euro-Brazilians, respectively (Table 3) (Boldt et al, 2009;Carrington et al, 1999;Jlizi et al, 2007). The group from Tunisia noticed high frequency of the L55Q variant among individuals of Berber origin (Jlizi et al, 2007). The highest frequency of 0.21 was observed in the Berber of Chenini-Douriet (38.46%) followed by a frequency of 0.07 in the Berber of Sajnene (14.28%, Table 3) (Jlizi et al, 2007).…”