Identification of Synaptic Patterns of NMDA Receptor Subtypes Upon Direction-Selective Rabbit Retinal Ganglion Cells

Kwon, Oh-Ju; Lee, Jung Hoon; Kim, Hang-Gu; Jeon, Chang‐Jin

doi:10.3109/02713683.2015.1056378

Cited by 3 publications

(2 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We previously reported that most glutamate receptors, including N-methyl- d -aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and kainate (KA) receptors, showed no anatomical evidence of asymmetry in their distribution patterns on the dendrites of the ON-OFF DS RGCs in the adult rabbit retina [ 26 , 30 , 31 ]. Taken together, our previous and present expressional pattern results indicate that the excitatory neurotransmitters receptor subunits have no critical effect on the anisotropy of the ON-OFF DS RGCs for the induction of direction selectivity.…”

Section: Discussionmentioning

confidence: 99%

“…These cells have bistratified dendrites at a depth of 20% and 70% of the inner plexiform layer (IPL) of the retina in sublamina a (OFF) and sublamina b (ON), respectively [ 7 , 11 , 13 , 29 , 49 , 50 , 57 ]. With their distinctive anatomical structures, various receptors are expressed in the ON-OFF DS RGCs [ 26 , 28 , 30 , 31 , 44 ], but the molecular profiles of the ON-OFF DS RGCs are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expression of Nicotinic Acetylcholine Receptor α4 and β2 Subunits on Direction-Selective Retinal Ganglion Cells in the Rabbit

Lee

Kim

Ahn

et al. 2017

Acta Histochem. Cytochem

Self Cite

View full text Add to dashboard Cite

The direction selectivity of the retina is a distinct mechanism that is critical function of eyes for survival. The direction-selective retinal ganglion cells (DS RGCs) strongly respond to a preferred direction, but rarely respond to opposite direction or null directional visual stimuli. The DS RGCs are sensitive to acetylcholine, which is secreted from starburst amacrine cells (SACs) to the DS RGCs. Here, we investigated the existence and distribution of the nicotinic acetylcholine receptor (nAChR) α4 and β2 subunits on the dendritic arbors of the DS RGCs in adult rabbit retina using immunocytochemistry. The DS RGCs were injected with Lucifer yellow to identify their dendritic morphology. The double-labeled images of dendrites and nAChR subunits were visualized for reconstruction using high-resolution confocal microscopy. Although our results revealed that the distributional pattern of the nAChR subunits on the dendritic arbors of the DS RGCs was not asymmetric in the adult rabbit retina, the distribution of nAChR α4 and β2 subunits and molecular profiles of cholinergic inputs to DS RGCs in adult rabbit retina provide anatomical evidence for direction selectivity.

show abstract

Section: Discussionmentioning

confidence: 99%