Identification of subdivisions in the medial geniculate body of the guinea pig

Anderson, Lucy A.; Wallace, Mark N.; Palmer, Alan R.

doi:10.1016/j.heares.2007.02.005

Cited by 60 publications

(64 citation statements)

References 47 publications

(102 reference statements)

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“…The lemniscal projection is tonotopically organised, and capable of conveying high-fidelity timing and tuning information, whereas the non-lemniscal pathway is thought to play a more important role in the representation of sound context, such as the behavioural significance of a sound or its probability of occurrence based on recent stimulus history. This proposal is supported by previous studies of single cell recordings from the ventral and dorsal MGB (Anderson et al., 2007 [guinea pig]; Calford and Aitkin, 1983 [cat]), as well as the current study.…”

Section: Discussionsupporting

confidence: 86%

“…As has been shown in other species, clear changes in response properties were frequently encountered as the electrode crossed between subdivision boundaries (Anderson et al., 2007 [guinea pig]; Calford, 1983 [cat]). Intracellular in-vitro studies have shown that in comparison to ventral and dorsal MGB neurons, medial MGB neurons are more excitable, have larger action potentials and do not exhibit the calcium bursting common to the ventral and dorsal MGB (Smith et al., 2006).…”

Section: Discussionmentioning

confidence: 60%

“…The MGB is considered the principal nucleus of the auditory thalamus and can be further subdivided into at least three major subdivisions (the ventral, dorsal and medial MGB) on the basis of anatomy, histochemistry and physiological response properties in a number of species (Anderson et al., 2007 [guinea pig]; Anderson et al., 2009b [mouse]; Calford, 1983 [cat]; Cruikshank et al., 2001 [mouse]; Gonzalez-Lima and Cada, 1994 [mouse]; Hackett et al., 1998 [monkey]; Morest, 1964 [cat]; Winer et al., 1999 [rat]). The relative positions of these subdivisions in the mouse MGB are shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

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Physiological differences between histologically defined subdivisions in the mouse auditory thalamus

Anderson

Linden

2011

Hearing Research

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The auditory thalamic area includes the medial geniculate body (MGB) and the lateral part of the posterior thalamic nucleus (Pol). The MGB can be subdivided into a ventral subdivision, forming part of the lemniscal (primary) auditory pathway, and medial and dorsal subdivisions, traditionally considered (alongside the Pol) part of the non-lemniscal (secondary) pathway. However, physiological studies of the auditory thalamus have suggested that the Pol may be more appropriately characterised as part of the lemniscal pathway, while the medial MGB may be part of a third (polysensory) pathway, with characteristics of lemniscal and non-lemniscal areas. We document physiological properties of neurons in histologically identified areas of the MGB and Pol in the anaesthetised mouse, and present evidence in favour of a distinctive role for medial MGB in central auditory processing. In particular, medial MGB contains a greater proportion of neurons with short first-spike latencies and high response probabilities than either the ventral or dorsal MGB, despite having low spontaneous rates. Therefore, medial MGB neurons appear to fire more reliably in response to auditory input than neurons in even the lemniscal, ventral subdivision. Additionally, responses in the Pol are more similar to those in the ventral MGB than the dorsal MGB.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

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Physiological differences between histologically defined subdivisions in the mouse auditory thalamus

Anderson

Linden

2011

Hearing Research

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“…Visual inspection of a retrograde tracer study by Winer et al (1999b) showed that cell clusters projecting to low-and high-frequency contours in A1 are positioned in dorsal and ventral parts of MGBv, respectively. This dorsal-to-ventral frequency organization resembles that of MGBv in other small mammals (Anderson et al, 2007;Cant and Benson, 2007;McMullen et al, 2005).…”

Section: Discussionsupporting

confidence: 59%

Thalamocortical pathway specialization for sound frequency resolution

Storace

Higgins

Read

2010

J of Comparative Neurology

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Core auditory cortices are organized in parallel pathways that process incoming sensory information differently. In the rat, sound filtering properties of the primary (A1) and ventral (VAF) auditory fields are markedly different, yet both are core regions that by definition receive most of their thalamic input from the ventral nucleus (MGBv) of the medial geniculate body (MGB). For example, spike rate responses to sound intensity and frequency are more narrowly resolved in VAF vs. A1. Here we question whether there are anatomic correlates of the marked differences in response properties in these two core auditory fields. Combined Fourier optical imaging and multiunit recording methods were used to map tone frequency responses with high spatial resolution in A1, VAF, and neighboring cortices. The cortical distance representing a given octave was similar, yet response frequency resolution was about twice as large in VAF as in A1. Retrograde tracers were injected into low- and high-isofrequency contours of both regions to compare MGBv label patterns. The distance between clusters of MGBv neurons projecting to low- and high-isofrequency contours in the cortex was twice as large in caudal as in rostral MGB. This suggests that differences in A1 and VAF frequency resolution are related to the anatomic spatial resolution of frequency laminae in the thalamus, supporting a growing consensus that antecedents of cortical specialization can be attributed in part to the structural and functional characteristics of thalamocortical inputs.

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“…In the auditory system, Pa-positive core thalamic neurons lie mostly within the ventral division of the medial geniculate nucleus (de Venecia, Smelser, Lossman, & McMullen, 1995; Jones, 2003), receive ascending inputs from the internal nucleus of the inferior colliculus (Winer & Schreiner, 2005; Oliver & Huerta, 1992), and exhibit narrow frequency tuning (Anderson, Wallace, & Palmer, 2007; Calford, 1983). They project mainly to Layer 4 and deep layer 3 of the auditory cortical “Core” regions including A1, and the more rostral regions (R and RT) (Hashikawa, Molinari, Rausell, & Jones, 1995; McMullen & de Venecia, 1993; Pandya, Rosene, & Doolittle, 1994; Kimura, Donishi, Sakoda, Hazama, & Tamai, 2003), where their pure tone preferences give rise to the well-known tonotopic maps of these regions.…”

Section: Integrating Tone and Rhythmmentioning

confidence: 99%

Thalamocortical mechanisms for integrating musical tone and rhythm

2014

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Studies over several decades have identified many of the neuronal substrates of music perception by pursuing pitch and rhythm perception separately. Here, we address the question of how these mechanisms interact, starting with the observation that the peripheral pathways of the so-called “Core” and “Matrix” thalamocortical system provide the anatomical bases for tone and rhythm channels. We then examine the hypothesis that these specialized inputs integrate tonal content within rhythm context in auditory cortex using classical types of “driving” and “modulatory” mechanisms. This hypothesis provides a framework for deriving testable predictions about the early stages of music processing. Furthermore, because thalamocortical circuits are shared by speech and music processing, such a model provides concrete implications for how music experience contributes to the development of robust speech encoding mechanisms.

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Identification of subdivisions in the medial geniculate body of the guinea pig

Cited by 60 publications

References 47 publications

Physiological differences between histologically defined subdivisions in the mouse auditory thalamus

Physiological differences between histologically defined subdivisions in the mouse auditory thalamus

Thalamocortical pathway specialization for sound frequency resolution

Thalamocortical mechanisms for integrating musical tone and rhythm

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