Identification of single‐nucleotide polymorphisms in 5′ end and exons of the <i>PRKAG3</i> gene in Hubbard White broiler, Leghorn layer, and three Chinese indigenous chicken breeds

Zhao, Chunjiang; Wang, C.F.; Deng, Xuemei; Gao, Yu Tang; Wu, Ch.

doi:10.1111/j.1439-0388.2006.00607.x

Cited by 13 publications

(11 citation statements)

References 8 publications

(14 reference statements)

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“…No SNP was detected in the corresponding position as observed in the porcine gene that caused the R225Q mutation (Zhao et al, 2006). Mutations at positions 2720 and 2786 of the cPRKAG3 gene were located in sequence corresponding to the fourth CBS domain of human PRKAG3 (Zhao et al, 2006). Additionally, an allele frequency study indicated that among the five chicken breeds, Leghorn layers have the least number of polymorphisms at the cPRKAG3 gene locus (Zhao et al, 2006).…”

Section: Ampk Subunit Gene Structure and Genomic Organizationmentioning

confidence: 92%

“…They found 12 potential SNPs (ten in exons 3, 4, 9 and 11, and two in 5 0 -end sequence), but only three of them resulted in amino acid substitutions (Zhao et al, 2006). No SNP was detected in the corresponding position as observed in the porcine gene that caused the R225Q mutation (Zhao et al, 2006). Mutations at positions 2720 and 2786 of the cPRKAG3 gene were located in sequence corresponding to the fourth CBS domain of human PRKAG3 (Zhao et al, 2006).…”

Section: Ampk Subunit Gene Structure and Genomic Organizationmentioning

confidence: 95%

“…The chicken AMPK gamma-3 subunit (cPRKAG3) gene is the best defined of the three cPRKAG genes. It consists of 12 coding and noncoding exons ranging in size from 73 to 759 bp and spans more than 4.1 kb on chromosome 7 ( Figure 4G) Zhao et al, 2006). Two transcript variants were reported for the cPRKAG3 gene.…”

Section: Ampk Subunit Gene Structure and Genomic Organizationmentioning

confidence: 98%

“…One such mutation (R225Q) occurs in the first CBS domain of the porcine PRKAG3 gene and causes a dominant phenotype characterized by very high skeletal muscle glycogen level with significant effects on meat quality and processing yield (Milan et al, 2000). Recently Zhao et al (2006) screened five chicken breeds, including Leghorn layers, Hubbard ISA White broilers and three native Chinese breeds, for potential polymorphisms in the cPRKAG3 gene. They found 12 potential SNPs (ten in exons 3, 4, 9 and 11, and two in 5 0 -end sequence), but only three of them resulted in amino acid substitutions (Zhao et al, 2006).…”

Section: Ampk Subunit Gene Structure and Genomic Organizationmentioning

confidence: 99%

“…Recently Zhao et al (2006) screened five chicken breeds, including Leghorn layers, Hubbard ISA White broilers and three native Chinese breeds, for potential polymorphisms in the cPRKAG3 gene. They found 12 potential SNPs (ten in exons 3, 4, 9 and 11, and two in 5 0 -end sequence), but only three of them resulted in amino acid substitutions (Zhao et al, 2006). No SNP was detected in the corresponding position as observed in the porcine gene that caused the R225Q mutation (Zhao et al, 2006).…”

Section: Ampk Subunit Gene Structure and Genomic Organizationmentioning

confidence: 99%

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5′-AMP-Activated protein kinase in avian biology

Proszkowiec‐Weglarz¹,

Richards²

2007

Avian & Poul. Biolog. Rev.

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To survive and perform basic metabolic processes, all living organisms must maintain a state of energy balance. Energy balance is achieved by increasing energy expenditure during periods of energy excess and decreasing energy expenditure during periods of energy deficit. In this review, we focus on 5 0 -AMP-activated protein kinase (AMPK), a heterotrimeric enzyme complex consisting of one catalytic and two regulatory subunits that is a key component in the pathway maintaining cellular and whole body energy balance. AMPK is widely expressed in mammalian as well as avian tissues. In response to states of negative energy balance, AMPK is activated through phosphorylation by upstream AMPK kinases. It then acts to increase the activities of those metabolic pathways that generate energy while decreasing the activities of energy-consuming pathways. As a result, AMPK is involved in the regulation of carbohydrate, lipid and protein metabolism. AMPK achieves its metabolic effects acutely by direct phosphorylation of many downstream target proteins and, long-term, by regulation of transcription factor and co-activator activities which leads to changes in gene transcription. AMPK responds not only to fluctuations in cellular energy level, but also to specific nutrients and hormones and thereby participates in the regulation of whole body energy balance and food intake. Recent work has begun to define the AMPK pathway in avian species where it most likely plays a similar role in maintaining energy balance and controlling food intake as it has been reported to do in mammals.

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Section: Ampk Subunit Gene Structure and Genomic Organizationmentioning

confidence: 92%

Section: Ampk Subunit Gene Structure and Genomic Organizationmentioning

confidence: 95%

Section: Ampk Subunit Gene Structure and Genomic Organizationmentioning

confidence: 98%

Section: Ampk Subunit Gene Structure and Genomic Organizationmentioning

confidence: 99%

Section: Ampk Subunit Gene Structure and Genomic Organizationmentioning

confidence: 99%

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5′-AMP-Activated protein kinase in avian biology

Proszkowiec‐Weglarz¹,

Richards²

2007

Avian & Poul. Biolog. Rev.

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Muscle transcriptome analysis reveals molecular pathways and biomarkers involved in extreme ultimate pH and meat defect occurrence in chicken

Beauclercq

Hennequet-Antier

Praud

et al. 2017

Sci Rep

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The processing ability and sensory quality of chicken breast meat are highly related to its ultimate pH (pHu), which is mainly determined by the amount of glycogen in the muscle at death. To unravel the molecular mechanisms underlying glycogen and meat pHu variations and to identify predictive biomarkers of these traits, a transcriptome profiling analysis was performed using an Agilent custom chicken 8 × 60 K microarray. The breast muscle gene expression patterns were studied in two chicken lines experimentally selected for high (pHu+) and low (pHu−) pHu values of the breast meat. Across the 1,436 differentially expressed (DE) genes found between the two lines, many were involved in biological processes related to muscle development and remodelling and carbohydrate and energy metabolism. The functional analysis showed an intensive use of carbohydrate metabolism to produce energy in the pHu− line, while alternative catabolic pathways were solicited in the muscle of the pHu+ broilers, compromising their muscle development and integrity. After a validation step on a population of 278 broilers using microfluidic RT-qPCR, 20 genes were identified by partial least squares regression as good predictors of the pHu, opening new perspectives of screening broilers likely to present meat quality defects.

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An SNP in Exon 11 of Chicken 5′-AMP-Activated Protein Kinase Gamma 3 Subunit Gene was Associated with Meat Water Holding Capacity

Yang

Xiong

Yao

et al. 2015

Animal Biotechnology

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The 5'-Adenosine-monophosphate -activated protein kinase plays a key role in regulating cellular energy homeostasis, and it was reported that nucleotide variants in the genes coding the protein were associated with meat quality. In the present study, genetic variations in the exons of gamma non-catalytic subunit genes of the protein kinase were screened among 284 White Plymouth Rock chickens from 7 families with denaturing gradient gel electrophoresis, and their meat quality traits including drip loss and cooked meat rate which reflect water holding capacity and serum biochemical indices were also measured, and the association between the genotypes and the traits was analyzed with a SAS GLM procedure. Our results showed that there were three G/A nucleotide variants including one in exon 6 of the gamma subunit 2 gene and two in exon 11 of the gamma subunit 3 gene, which resulted in amino acid substitutions V150I, V315 M, and A337 T, respectively. And locus V315 M was associated with water holding capacity significantly (P < 0.05). The studied polymorphic locus has the potential to be used as a genetic marker for poultry breeding work.

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Identification of single‐nucleotide polymorphisms in 5′ end and exons of the PRKAG3 gene in Hubbard White broiler, Leghorn layer, and three Chinese indigenous chicken breeds

Cited by 13 publications

References 8 publications

5′-AMP-Activated protein kinase in avian biology

5′-AMP-Activated protein kinase in avian biology

Muscle transcriptome analysis reveals molecular pathways and biomarkers involved in extreme ultimate pH and meat defect occurrence in chicken

An SNP in Exon 11 of Chicken 5′-AMP-Activated Protein Kinase Gamma 3 Subunit Gene was Associated with Meat Water Holding Capacity

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