Identification of SEPP1 polymorphisms is not a genetic risk factor for preeclampsia in Chinese Han women

Wu, Hong; Jia, Xiaoyan; Zhao, Hengli; Huang, Youmin; Liu, Chang; Huang, Zuzhou; Li, Shunjun; Wang, Jingli

doi:10.1097/md.0000000000007249

Cited by 4 publications

(4 citation statements)

References 34 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The full text of 8 papers were in Chinese, and they were assessed by one of the authors (JH). Overall, 43 studies met the criteria and were used for data extraction 46 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , and six were suitable for meta-analysis [ 68 , 72 , 87 , 96 , 100 , 108 ].…”

Section: Resultsmentioning

confidence: 99%

Blood biomarkers to predict the onset of pre-eclampsia: A systematic review and meta-analysis

Danielli

Thomas

Gillies

et al. 2022

Heliyon

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Blood biomarkers to predict the onset of pre-eclampsia: A systematic review and meta-analysis

Danielli

Thomas

Gillies

et al. 2022

Heliyon

View full text Add to dashboard Cite

“…Although increasing levels of estrogen throughout pregnancy modulate selenoprotein P and subsequently affect tissue distribution of Se, inadequate Se intake will ultimately lead to low plasma selenoprotein P levels [ 18 , 19 , 20 ]. The downregulation of selenoprotein P encoded by Sepp1 will promote oxidative stress throughout pregnancy [ 83 , 84 , 85 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Selenium Status by Age and Gender: A Retrospective Observational Cohort Study in Western Romania

et al. 2021

View full text Add to dashboard Cite

Selenium, residing in a series of selenoproteins, plays an important role in both female and male reproductive function. Of particular significance for reproduction is the antioxidant glutathione peroxidase (GPx), a main selenoenzyme, whose level is regulated by the availability of Se in the body. We hypothesized that changes in Se status, closely related to GPx activity, would result in an increased risk of reproductive dysfunction in individuals. We retrospectively investigated the serum selenium (SeS) concentrations of 1264 apparently healthy people, aged 16–89 years, from Western Romania. The general analysis revealed a non-normal SeS distribution with a median SeS of 100.26 ± 18.32 μg/L and a significant difference in SeS levels between age groups. The analysis of the young group (16–35 years) revealed that up to 50% of individuals did not reach the SeS threshold corresponding to maximum GPx activity (80 μg/L), and a significant imbalance between the genders was apparent when looking at SeS values outside the range. Our results correlated with the general diminished reproductive ability registered in Romania during the last few years. Serum selenium content proves to offer a proper reflection of the fertility competence of the young population, and its monitoring is important for guiding dietary adjustments and attaining normal reproductive function.

show abstract

“…Genotyping of 8 and 10 candidate SNPs related to inflammatory and oxidative stress, respectively, (Tables 1 and 2) was performed using predesigned TaqMan allelic discrimination real-time PCR followed by partial validation by Sanger sequencing. All women who were genotyped were retrospectively confirmed from our previous studies [23][24][25][26][27][28][29][30][31][32][33][34].…”

Section: Methodsmentioning

confidence: 99%

Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia

Chen

Zhao

Wang

et al. 2020

Journal of Immunology Research

Self Cite

View full text Add to dashboard Cite

Unbalanced inflammatory reactions and oxidative stress are inseparably interconnected, and both may play crucial roles in the pathophysiological mechanisms of preeclampsia (PE). In the published previous studies, we have genotyped for SNPs that related to inflammation (rs2227485, rs153109, rs17855750, rs2027432, rs2275913, rs763780, rs4819554, and rs13015714) and oxidative stress (rs1695, rs4680, rs1800566, rs4807542, rs713041, rs7579, rs230813, rs1004467, rs3824755, and rs9932581) to investigate whether these polymorphisms were associated with susceptibility to PE in a Chinese Han population. In this present study, we collected these data of experimental and clinical from above studies for haplotype analysis of inflammation-related SNPs in 631 PE patients and 720 normal pregnancy and oxidative stress-related SNPs in 342 PE patients and 457 normal pregnancies for susceptibility to PE. The data of genotype distribution and allele frequency comparisons after correction for multiple comparisons (P/8 or P/10) showed 2 among the 8 candidate inflammation-related SNPs have significant differences (rs2027432 genotype χ2=407.377,p<0.001,p<0.00625). Moreover, the minor alleles of rs2027432 T (minor allele χ2=450.923,p<0.001,p<0.00625;OR=21.439,95%CI=15.181‐30.278) and rs4819554 G (minor allele χ2=163.465,p<0.001,p<0.00625;OR=5.814,95%CI=4.380‐7.719) were confirmed as risk allele of PE, respectively. Our analysis revealed rs2027432 (TT) of NLRP3 and rs4819554 (GG) of IL-17RA are risk factors for PE. However, no significant difference was found at the oxidative stress-related SNPs. In the candidate loci for oxidative stress, we also identified 3 SNP matches (rs4807542 and rs713041, rs230813 and rs75799, rs1004467 and rs3824755) that had high linkage disequilibrium (LD) with each other and were selected as a block (r2=0.98,r2=0.97,r2=0.97,r2>0.9), and the GT and GC haplotypes of rs4807542 and rs713041 in GPX4 showed significant differences between the PE and control groups (χ2=5.143,p=0.0233,p<0.05;χ2=6.373,p=0.0116,p<0.05). So, we inferred that polymorphisms of NLRP3 rs2027432 and IL-17RA rs4819554, which are related to inflammation, and the rs713041 variant of GPX4, which is related to oxidative stress, were associated with susceptibility to PE. The GT and GC haplotypes of rs4807542 and rs713041 in GPX4 may increase the risk of PE in the Chinese Han population.

show abstract

Identification of SEPP1 polymorphisms is not a genetic risk factor for preeclampsia in Chinese Han women

Cited by 4 publications

References 34 publications

Blood biomarkers to predict the onset of pre-eclampsia: A systematic review and meta-analysis

Blood biomarkers to predict the onset of pre-eclampsia: A systematic review and meta-analysis

Evaluation of Serum Selenium Status by Age and Gender: A Retrospective Observational Cohort Study in Western Romania

Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia

Contact Info

Product

Resources

About