Evaluation of Serum Selenium Status by Age and Gender: A Retrospective Observational Cohort Study in Western Romania

Bizerea-Moga, Teofana Otilia; Pitulice, Laura; Bizerea-Spiridon, Otilia; Moga, Tudor

doi:10.3390/nu13051497

Cited by 8 publications

(7 citation statements)

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“…From a physiological perspective, selenium uptake may represent a primary modifiable factor that may account for differential susceptibility to stroke and infection. The optimal concentration levels in adult human blood serum are 80 to 120 mcg/L, though there is a great variety of normal values from country to country [ 14 , 115 ]. However, selenium concentration is age dependent [ 116 , 117 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, absorption of selenocompounds by the intestinal epithelia seems to be greater in females (~96%) [ 120 ] compared to males (~76%) [ 121 ]. A recent study in western Romania found that selenium uptake was lower in females compared to males [ 115 ]. Although these studies cannot provide a mechanism for these differences, they nevertheless should be taken into account when interpreting data and designing future studies.…”

Section: Discussionmentioning

confidence: 99%

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Selenium, Stroke, and Infection: A Threefold Relationship; Where Do We Stand and Where Do We Go?

et al. 2023

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Stroke is currently the second most common cause of death worldwide and a major cause of serious long-term morbidity. Selenium is a trace element with pleotropic effects on human health. Selenium deficiency has been associated with a prothrombotic state and poor immune response, particularly during infection. Our aim was to synthesize current evidence on the tripartite interrelationship between selenium levels, stroke, and infection. Although evidence is contradictory, most studies support the association between lower serum selenium levels and stroke risk and outcomes. Conversely, limited evidence on the role of selenium supplementation in stroke indicates a potentially beneficial effect of selenium. Notably, the relationship between stroke risk and selenium levels is bimodal rather than linear, with higher levels of serum selenium linked to disturbances of glucose metabolism and high blood pressure, morbidities which are, in turn, substrates for stroke. Another such substrate is an infection, albeit forming a bidirectional relationship with both stroke and the consequences of impaired selenium metabolism. Perturbed selenium homeostasis leads to impaired immune fitness and antioxidant capacity, which both favor infection and inflammation; specific pathogens may also contend with the host for transcriptional control of the selenoproteome, adding a feed-forward loop to this described process. Broader consequences of infection such as endothelial dysfunction, hypercoagulation, and emergent cardiac dysfunction both provide stroke substrates and further feed-forward feedback to the consequences of deficient selenium metabolism. In this review, we provide a synthesis and interpretation of these outlined complex interrelationships that link selenium, stroke, and infection and attempt to decipher their potential impact on human health and disease. Selenium and the unique properties of its proteome could provide both biomarkers and treatment options in patients with stroke, infection, or both.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Selenium, Stroke, and Infection: A Threefold Relationship; Where Do We Stand and Where Do We Go?

et al. 2023

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“…Pursuant to a collaboration agreement with “Victor Babeș” University of Medicine and Pharmacy from Timișoara, Bioclinica provided services for the analysis of microelements from human fluids. Se analyses were performed using an inductively coupled plasma mass spectrometry (ICP-MS) method, as described elsewhere ( 33 ).…”

Section: Methodsmentioning

confidence: 99%

“…However, among biomarkers used to assess Se status, blood and urine Se easily translate into use in neonate clinical settings. Blood contains almost half of the body's selenium, and blood Se concentration properly reflects Se intake or exposure; whole blood and erythrocyte Se reflect long-term status, while the serum/plasma Se (SeS) indicates short-term status ( 32 , 33 ). Urine, on the other hand, is the main route of Se excretion ( 34 , 35 ) with a selenosugar (1 β -methylseleno-N-acetyl-D-galactosamine) being the predominant speciation ( 34 ).…”

Section: Introductionmentioning

confidence: 99%

Selenium status in term neonates, according to birth weight and gestational age, in relation to maternal hypertensive pathology

et al. 2023

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BackgroundPregnancy represents a state of increased oxidative stress and antioxidants, in which selenium (Se) plays a pivotal role, contribute to maintain the oxidative balance. If antioxidant defenses are depleted, placental function is disrupted, resulting in pregnancy complications, including pregnancy-induced hypertension (PIH). Little is known about fetal selenium status in concomitant relation to maternal PIH, gestational age (GA) and birthweight (BW).MethodsWe examined over a 3-year period the serum (SeS) and urine selenium (SeU) status in term neonates from normotensive (nonPIH) and hypertensive (PIH) mothers as clinical markers of oxidative stress. In this retrospective observational study, 72 neonates with maternal PIH were matched for GA and BW to 72 neonates of normotensive mothers. Four groups were obtained, based on maternal PIH and BW relative to GA (appropriate-for-gestational-age—AGA, small-for-gestational-age—SGA): nonPIH-AGA (control group), nonPIH-SGA, PIH-AGA, and PIH-SGA.ResultsThe results showed significant differences (p < 0.001) in selenium levels among the study groups: SeS - 44.85 ± 7.56 μg/L in nonPIH-AGA, 39.62 ± 11.42 μg/L in nonPIH-SGA, 40.01 ± 10.07 μg/L in PIH-AGA, and 25.39 ± 8.99 μg/L in PIH-SGA; SeU - 27.98 ± 7.99 μg/L in nonPIH-AGA, 22.85 ± 9.48 μg/L in nonPIH-SGA, 23.44 ± 6.73 μg/L in PIH-AGA, and 13.05 ± 5.86 μg/L in PIH-SGA. Selenium depletion was more common in neonates born from hypertensive mothers and those born small for gestational age. Though moderate in intensity, selenium levels were positively correlated with BW (0.319 for SeS, 0.397 for SeU) and negatively correlated with maternal systolic blood pressure (−0.313 for SeS, −0.324 for SeU). The main independent effects on SeS and SeU of each maternal blood pressure and birth weight turned out statistically significant. In interaction, a more pronounced effect was reached in PIH-SGA neonates.ConclusionSelenium status seemed to reflect the negative impact that PIH exerts in neonates during intrauterine development. Clinical markers of selenium status could thus be of great value for tracking responses of individuals to selenium supplementation as part of health improvement and harm mitigation approaches.

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“…In addition, the metabolic and physiological functions, including excretion function, of older adults are gradually impaired during the aging process ( 20 , 21 ). Therefore, compared with other age groups, older adults have higher selenium levels and more cases of high selenium ( 22 – 24 ). Moreover, aging adults experience multisystem functional impairment and increasing susceptibility to multiple chronic diseases ( 25 ).…”

Section: Introductionmentioning

confidence: 99%

Novel Strategies for Assessing Associations Between Selenium Biomarkers and Cardiometabolic Risk Factors: Concentration, Visit-to-Visit Variability, or Individual Mean? Evidence From a Repeated-Measures Study of Older Adults With High Selenium

Zhou

Mei

et al. 2022

Front. Nutr.

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Background and AimsPrevious studies have focused only on the cardiometabolic effects of selenium concentrations. We explored whether selenium levels and their visit-to-visit variability (VVV) and individual mean (IM) are independently associated with cardiometabolic risk factors.MethodsA three-wave repeated-measures study of older adults with high selenium (n = 201) was conducted in Beijing from 2016 to 2018. Whole blood selenium and urinary selenium concentrations were measured. VVV and IM were used to profile the homeostasis of the selenium biomarkers. Four indicators, namely standard deviation, coefficient of variation, average real variability, and variability independent of the mean, were employed to characterize VVV. We considered 13 cardiometabolic factors: four lipid profile indicators, three blood pressure indices, glucose, uric acid, waistline, hipline, waist-hip ratio, and sex-specific metabolic syndrome score. Linear mixed-effects regression models with random intercepts for the participants were employed to explore the associations of the selenium concentrations, VVV, and IM with the cardiometabolic factors.ResultsThe geometric mean whole blood and urinary selenium levels were 134.30 and 18.00 μg/L, respectively. Selenium concentrations were significantly associated with numerous cardiometabolic factors. Specifically, whole blood selenium was positively associated with total cholesterol [0.22, 95% confidence interval (CI): 0.12, 0.33], low-density lipoprotein cholesterol (LDL-C; 0.28, 95% CI: 0.13, 0.42), glucose (0.22, 95% CI: 0.10, 0.34), and uric acid (0.16, 95% CI: 0.04, 0.28). After adjustment for VVV, the IM of whole blood selenium was positively correlated with total cholesterol (0.002, 95% CI: 0.001, 0.004), triglycerides (0.007, 95% CI: 0.004, 0.011), and LDL-C (0.002, 95% CI: 0.000, 0.004). However, we did not observe any robust associations between the VVV of the selenium biomarkers and cardiometabolic risk factors after adjustment for IM.ConclusionOur findings suggest that selenium concentrations and their IMs are significantly associated with cardiometabolic risk factors among older adults with high selenium. Longer repeated-measures studies among the general population are required to validate our findings and elucidate the relevant underlying mechanisms.

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Evaluation of Serum Selenium Status by Age and Gender: A Retrospective Observational Cohort Study in Western Romania

Cited by 8 publications

References 79 publications

Selenium, Stroke, and Infection: A Threefold Relationship; Where Do We Stand and Where Do We Go?

Selenium, Stroke, and Infection: A Threefold Relationship; Where Do We Stand and Where Do We Go?

Selenium status in term neonates, according to birth weight and gestational age, in relation to maternal hypertensive pathology

Novel Strategies for Assessing Associations Between Selenium Biomarkers and Cardiometabolic Risk Factors: Concentration, Visit-to-Visit Variability, or Individual Mean? Evidence From a Repeated-Measures Study of Older Adults With High Selenium

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