Identification of Rheumatoid Factor in Periodontal Disease

Gargiulo, Anthony W.; Robinson, John A.; Toto, Patrick D.; Gargiulo, and Anthony W.

doi:10.1902/jop.1982.53.9.568

Cited by 51 publications

(41 citation statements)

References 30 publications

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“…This contrasts with reports showing that RF can be detected in the gingiva, subgingival plaque, and serum of patients with PD (42, 43). Locally-produced RF in PD appears to be most closely linked to infections with Fusobacterium nucleatum and Capnocytophaga ochracea , oral pathogens that do not express PAD (42, 44).…”

Section: Discussioncontrasting

confidence: 99%

Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis

Mikuls

Payne

Reinhardt

et al. 2009

International Immunopharmacology

243

205

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Summary Antibody titers to P. gingivalis are increased in patients with rheumatoid arthritis and are associated with disease-specific autoimmunity. Background Periodontitis (PD) has been implicated as a risk factor for rheumatoid arthritis (RA). We sought to characterize antibody titers to P. gingivalis (a pathogen in PD) in subjects with RA, PD, and in healthy controls and to examine their relationship with disease autoantibodies. Methods P. gingivalis antibody was measured in subjects with RA (n = 78), PD (n = 39), and in controls (n = 40). Group frequencies of bacterial titer elevations were compared using the Chi-square test and antibody titers were compared using non-parametric tests. Correlations of P. gingivalis titer with C-reactive protein (CRP), antibody to cyclic citrullinated peptide (anti-CCP), and rheumatoid factor (RF) were examined in those with RA while CRP and autoantibody concentrations were compared based on seropositivity to P. gingivalis. Results Antibody titers to P. gingivalis were highest in PD, lowest in controls, and intermediate in RA (p = 0.0003). Elevations in P. gingivalis (titer ≥ 800) were more common in RA and PD (67% and 77%, respectively) than in controls (40%) (p = 0.002). In RA, there were significant correlations with P. gingivalis titer with CRP, anti-CCP-IgM, and -IgG-2. CRP (p = 0.006), anti-CCP-IgM (p = 0.01) and -IgG2 (p = 0.04) concentrations were higher in RA cases with P. gingivalis titers ≥ 800 compared to cases with titers < 800. Conclusion Antibodies to P. gingivalis are more common in RA subjects than controls, although lower than that in PD. Associations of P. gingivalis titers with RA-related autoantibody and CRP concentrations suggests that infection with this organism plays a role in disease risk and progression in RA.

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Section: Discussioncontrasting

confidence: 99%

Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis

Mikuls

Payne

Reinhardt

et al. 2009

International Immunopharmacology

243

205

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“…This similarity between RA and periodontal disease has prompted many studies [3,8,10,11,17]. MALMSTROM AND CALONIUS [11] have shown an increased frequency of edentulous patients and more missing teeth in patients with RA, when compared Table 4 Immunoglobulin levels in 15 systemically and periodontally healthy control subjects (mg/dl) with control subjects.…”

Section: Resultsmentioning

confidence: 99%

Clinical and Immunological Characteristics of Patients with Rheumatoid Arthritis and Periodontal Disease.

Yavuzyilmaz

Yamalik

Calguner

et al. 1992

The Journal of Nihon University School of Dentistry

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“…RF has been detected in the gingiva, subgingival plaque, saliva, and serum of patients with various periodontal diseases, particularly in patients with AP (41)(42)(43)(44)(45). However, the characteristics and precise function of RF in periodontal disease has not yet been established.…”

Section: Rheumatoid Factor In Periodontal Diseasementioning

confidence: 99%

Hypothesis: The Humoral Immune Response to Oral Bacteria Provides a Stimulus for the Development of Rheumatoid Arthritis

et al. 2004

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Rheumatoid arthritis (RA) and adult periodontitis share common pathogenetic mechanisms and immunologic and pathological findings. One oral pathogen strongly implicated in the pathogenesis of periodontal disease, Porphyromonas gingivalis, possesses a unique microbial enzyme, peptidylarginine deiminase (PAD), the human equivalent of which has been identified as a susceptibility factor for RA. We suggest that individuals predisposed to periodontal infection are exposed to antigens generated by PAD, with de-iminated fibrin as a likely candidate, which become systemic immunogens and lead to intraarticular inflammation. PAD engendered antigens lead to production of rheumatoid factor-containing immune complexes and provoke local inflammation, both in gingiva and synovium via Fc and C5a receptors.

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Identification of Rheumatoid Factor in Periodontal Disease

Cited by 51 publications

References 30 publications

Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis

Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis

Clinical and Immunological Characteristics of Patients with Rheumatoid Arthritis and Periodontal Disease.

Hypothesis: The Humoral Immune Response to Oral Bacteria Provides a Stimulus for the Development of Rheumatoid Arthritis

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