Identification of renin inhibitors peptides from amaranth proteins by docking protocols

Nardo, Agustina Estefanía; Añón, Marı́a Cristina; Quiroga, Alejandra Viviana

doi:10.1016/j.jff.2019.103683

Cited by 16 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results did not totally agree with score values obtained with FlexPepDock, which predicted a higher affinity for SFNLPILR followed by AFEDGFEWVSKF and FNLPILR. Nardo et al (2020) stated that these inconsistencies had already been reported by other authors, attributing the problem to the scoring function of the docking technique using peptides as ligands.…”

Section: Renin Inhibitory Peptidesmentioning

confidence: 97%

“…Using bioinformatics tools, Nardo et al (2020) analyzed the interaction of the aforementioned peptides with renin. Initially, they used the CABS-dock server to perform a global docking assay on the enzyme surface, to obtain the renin-peptide complexes and to analyze the residues involved in the interaction.…”

Section: Renin Inhibitory Peptidesmentioning

confidence: 99%

“…Using bioinformatics tools, Nardo et al. (2020) analyzed the interaction of the aforementioned peptides with renin.…”

Section: Bioactive Peptides As Blood Pressure Regulatorsmentioning

confidence: 99%

“…On the other hand, it has recently been demonstrated that amaranth storage proteins, like other proteins of plant and animal origin, have encrypted amino acid sequences displaying different physiological activities: antihypertensive, antioxidant, antiproliferative/antitumor, antithrombotic, antihaemolitic, antimicrobial, hypocholesterolemic, hypoglycemic, and immunomodulatory. These sequences can be released by enzymatic treatment, through fermentative processes or during the gastrointestinal digestion ( Barrio and Añón, 2010 ; Lado et al., 2015 ; Sabbione et al., 2016a ; Sabbione et al., 2016b ; Moronta et al., 2016a ; Moronta et al., 2016b ; Orsini Delgado et al., 2016 ; García Fillería and Tironi, 2017 ; Quiroga et al., 2017 ; Orona-Tamayo et al., 2019 ; Martinez-Lopez et al., 2020 ; Nardo et al., 2020 ; Suárez et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Amaranth as a Source of Antihypertensive Peptides

et al. 2020

Self Cite

View full text Add to dashboard Cite

Amaranth is an ancestral crop used by pre-Columbian cultures for 6000 to 8000 years. Its grains have a relevant chemical composition not only from a nutritional point of view but also due to the contribution of components with good techno-functional properties and important potential as bioactive compounds. Numerous studies have shown that amaranth storage proteins possess encrypted sequences that, once released, exhibit different physiological activities. One of the most studied is antihypertensive activity. This review summarizes the progress made over the last years (2008-2020) related to this topic. Studies related to inhibition of different enzymes of the Renin-Angiotensin-Aldosterone system, in particular Angiotensin Converting Enzyme (ACE) and Renin, as well as those referring to potential modulation mechanisms of tissue or local Renin-Angiotensin-Aldosterone system, are analyzed, including in silico, in vitro, in vivo, and ex vivo assays. Furthermore, the potential use of these bioactive peptides or products containing them, in the elaboration of functional food matrices is discussed. Finally, the most relevant conclusions and future requirements in research and development of food products are presented.

show abstract

Section: Renin Inhibitory Peptidesmentioning

confidence: 97%

Section: Renin Inhibitory Peptidesmentioning

confidence: 99%

“…Using bioinformatics tools, Nardo et al. (2020) analyzed the interaction of the aforementioned peptides with renin.…”

Section: Bioactive Peptides As Blood Pressure Regulatorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Amaranth as a Source of Antihypertensive Peptides

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Daging merah juga mengandung zat besi, yang sangat penting bagi wanita. Pedoman USDA merekomendasikan makan 7 ons makanan berprotein per hari [8]. Jika Kita memang makan daging, unggas, atau ikan, cobalah untuk memilih potongan tanpa lemak dan lebih sering memilih ayam atau ikan.…”

Section: Makanan Berprotein (Daging Ikan Unggas Telur Kacang-kacangan)unclassified

Pelatihan Pengolahan Makanan Sehat Ibu-Ibu PKK Kelurahan Bulu Lor Semarang Utara

Wibowo

Gamayanto

2021

View full text Add to dashboard Cite

Dengan banyaknya bidang usaha bisnis, terutama makanan cepat saji yang sangat menjamur kadangkala mengakibatkan ibu ibu lebih senang beli makanan yang sudah siap, karena praktis tidak repot belanja, memasak dan lain lain. Apalagi di era semua serba elektronik dimana cara berbelanja semakin mudah dan praktis, banyak beberapa pengusaha makanan yang cara pemasaranya dengan menggunakan media elektronik, seperti gofood, akan semakin membuat kita khususnya ibu ibu yang relative sibuk lebih memilih menggunakan jasa gofood. Yang kita tidak tau pasti bagaimana kebersihan maupun kandungan gizi yang ada berkaitan dengan cara memasaknya. Berdasarkan analisis situasi dan identifikasi masalah tersebut diatas, maka dapat dirumuskan sebuah permasalahan yaitu bagaimana cara memberikan pelatihan pengolahan makanan yang sehat dan murah agar kebutuhan gizi dan kesehatan tetap terjaga. Hasil dari pengabdian masyarakat ini adalah ibu-ibu PKK Kelurahan Bulu Lor Semarang Utara dapat memahami bagaimana cara menyimpan, mengelola dan mempertahankan gizi pada makanan sehingga hal tersebut akan dapat menjaga kesehatan dan dapat meningkatkan kesehatan di masa yang akan datang. Pengabdian masyarakat ini akan terus berlangsung dan akan terdapat kegiatan-kegiatan lain yang berhubungan dengan kesehatan dan peningkatan gizi bagi Kelurahan Bulu Lor Semarang Utara. Hal ini diperlukan untuk meningkatkan pola hidup di sehat pada masyarakat khususnya Kelurahan Bulu Lor Semarang Utara Kata kunci: Pelatihan, Kelurahan Bulu Lor, Makanan Sehat, Pengolahan, PKK

show abstract