Identification of radiolucent foreign bodies in tissue using optoacoustic spectroscopic imaging

Page, Leland; Maswadi, Saher; Glickman, Randolph D.

doi:10.1117/12.875403

Cited by 2 publications

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“…In this context, PAI, combining the merits of optical and ultrasound imaging, is emerging as a powerful modality for FB detection and characterization. 13,24,30,47 It offers great potential for generating high-quality images of traumatic injuries with retained radiolucent FBs that have poor or no contrast in X-ray-based modalities. 24,47 Moreover, the optical absorption spectrum of the object can be determined with multispectral imaging or spectroscopy, which may enable identification of the FB material, 24 possibly assisting the physician in selecting the optimal extraction approach.…”

Section: Fb Detectionmentioning

confidence: 99%

Photoacoustic Imaging and Sensing: A New Way to See the Eye

Glickman

2021

Journal of Ocular Pharmacology and Therapeutics

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Purpose: Photoacoustics (optoacoustics) is a hybrid technology utilizing light excitation of acoustic responses in targets of interest. It has found numerous applications in biomedicine, including eye research, because of its ability to report both morphological and functional data about the interrogated tissue. This presentation will give an overview of current applications. Methods: Wavelength-dependent absorption of light in a tissue chromophore causes local heating, leading to a thermoelastic expansion-contraction cycle. If nanosecond pulses of light are used to excite this process, the resulting pressure wave is an ultrasound signal propagating through the tissue and detectable at the tissue surface. This is highly advantageous because of the known properties of ultrasound propagation in tissue and the ability to use standard, medical ultrasound equipment for detection. The time of arrival and amplitude of ultrasound signals provide information about the location and nature of the absorber. Results: Due to the wavelength dependence of the photoacoustic response, functional and physiological applications are possible. For example, retinal oximetry can be determined from the different optical absorption properties of oxy-and deoxyhemoglobin. Multispectral imaging of the posterior segment can identify pigments such as melanin or lipofuscin or the nature of foreign bodies. The technique can be combined with other imaging modalities such as ultrasound and optical coherence tomography to produce high-resolution images of retinal structures along with functional information. Conclusion: Photoacoustic technology is a powerful noninvasive tool for ocular research and to study ocular morphology, fundamental physiological parameters, cellular responses, and molecular expression.

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Section: Fb Detectionmentioning

confidence: 99%

Photoacoustic Imaging and Sensing: A New Way to See the Eye

Glickman

2021

Journal of Ocular Pharmacology and Therapeutics

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Rare Earth Nanocomposites Based on Chitosan Platforms for Biological Applications

et al. 2012

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Chitosan (CHIT), a natural biopolymer, has established its applicability in numerous studies including, tissue scaffolds, topical antimicrobial agents, glucose biosensors and drug delivery platforms. Among these applications, biosensors utilizing CHIT has been championed due its excellent film-forming ability, biocompatibility, good adhesion, non-toxicity, and susceptibility to chemical modification due to the presence of plentiful amino groups and hydroxyl groups. The challenge in development of many biosensing materials is that they should offer robust and tunable characteristics (fluorescence, magnetic, thermal, etc.) while remaining biocompatible. In this work, a facile method was developed to synthesize biocompatible hetero-nanoparticles which inherently display multifunctionality based on a few interchangeable components. As an example, we present a system composed of rare earth metal oxide (REMO) nanoparticles, Er doped Y2O3, with the attachment of gold nanostructures using CHIT. The resulting REMO@CHIT@Au0 hybrid nanoparticles are capable of displaying tunable optical properties due to the surface plasmon resonance of the gold nanoparticles useful to photoacoustic applications. An overview of the nanostructure components are given followed by morphological and spectroscopic analyses. The results of the characterizations are the focus of our future work towards the applicability of these systems to biological sensing, detection and contrast agents.

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Identification of radiolucent foreign bodies in tissue using optoacoustic spectroscopic imaging

Cited by 2 publications

References 0 publications

Photoacoustic Imaging and Sensing: A New Way to See the Eye

Photoacoustic Imaging and Sensing: A New Way to See the Eye

Rare Earth Nanocomposites Based on Chitosan Platforms for Biological Applications

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