Identification of Prostaglandins in Central Nervous Tissues of the Cat and Chicken

Horton, E. W.; Main, I H

doi:10.1111/j.1476-5381.1967.tb02165.x

Cited by 81 publications

(44 citation statements)

References 28 publications

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“…Avanzino et al (1966) reported qualitative differences in the response of different brain stem neurones, but qualitative differences were never found in spinal cats by Horton & Main (1967a Latent period and duration of action. The duration of effects in this investigation was considerably longer than the duration of those reported by Horton & Main (1967 a) in spinal cats. The effects were reminiscent of the very prolonged actions following the injection of small doses of prostaglandins E into the cerebral ventricles of unanaesthetized cats (Horton, 1964;Horton & Main, 1965) effects which started some 20 min after the injection and lasted up to 48 hr.…”

Section: Prostaglandins and Reflex Responsescontrasting

confidence: 50%

“…Prostaglandins have been shown to have pharmacological actions on the brain and spinal cord (Horton, 1964;Horton & Main, 1965;Avanzino, 152 P. DUDA AND OTHERS Bradley & Wolstencroft, 1966;Horton & Main, 1967 a;Holmes & Horton 1968). In the present investigation, the actions of three prostaglandins have been studied on spinal reflexes by intra-arterial injection close to the spinal cord.…”

Section: Introductionmentioning

confidence: 99%

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The effects of prostaglandins E₁, F_1α and F_2α on monosynaptic reflexes

Duda¹,

Horton²,

McPherson³

1968

The Journal of Physiology

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SUMMARY1. Experiments, using electrophysiological recording techniques, were carried out to confirm the report that prostaglandins affect spinal reflexes in cats.2. Ventral root potentials evoked by stimulation of the ipsilateral dorsal root were recorded. Those with a latent period corresponding to a monosynaptic pathway were used primarily in this investigation. 6. It is concluded that prostaglandins, two of which have previously been identified in cat brain extracts, have pronounced and long-lasting effects on monosynaptic spinal reflexes.

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Section: Prostaglandins and Reflex Responsescontrasting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

The effects of prostaglandins E₁, F_1α and F_2α on monosynaptic reflexes

Duda¹,

Horton²,

McPherson³

1968

The Journal of Physiology

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“…collected during the pyrogen fever were subjected to thin layer chromatography, the activity was found to be present mainly or solely in the zone corresponding to the position of the prostaglandins of the E series. Since only E1 and F2, have so far been identified in cat's brain (Horton & Main, 1967) the activity of the c.s.f. samples tested on the rat stomach fundus strip preparation would appear to be due to prostaglandin E1.…”

Section: Discussionmentioning

confidence: 99%

“…(Horton & Main, 1967;Holmes & Horton, 1968;Holmes, 1970 W. FELDBERG AND K. P. GUPTA injected into the cerebral ventricles of unanaesthetized cats, rabbits or rats, minute amounts of PGE1 were found to produce fever by an action on the anterior hypothalamus. Of other prostaglandins examined only PGE2 was found to share with PGE1 the property of raising temperature (Milton & Wendlandt, 1970, 1971Feldberg & Saxena, 1971 a, b).…”

Section: Introductionmentioning

confidence: 99%

Pyrogen fever and prostaglandin‐like activity in cerebrospinal fluid

Feldberg¹,

Gupta²

1973

The Journal of Physiology

186

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1. In the unanaesthetized cat, rectal temperature was recorded and c.s.f. was collected from a Collison cannula implanted into the third ventricle with its opening lying in close proximity to the anterior hypothalamus. Samples of c.s.f. were collected from the same cat, during normal temperature, during fever produced by Shigella dysenteriae injected into the third ventricle and during the fall in temperature which occurred when the antipyretic paracetamol was injected intraperitoneally during the pyrogen fever. 2. The samples of c.s.f., when tested on the rat stomach fundus preparation, caused contractions which were not due, or at most to a small degree only, to 5‐hydroxytryptamine, as they were resistant to BOL. They were therefore probably due to a prostaglandin‐like substance. 3. When assayed against PGE1, the activity of c.s.f. collected from cats when their body temperature was normal corresponded to between 1·3 and 10 ng/ml. The values, whether low or high, rose over 2·5‐4 times to between 4 and 35 ng/ml. in c.s.f. collected during pyrogen fever; they were again low, between 1·5 and 6 ng/ml., in samples collected when the fever had been brought down by paracetamol, but rose again with the return of fever. 4. The results provide direct evidence for the theory that fever produced by pyrogens results from their ability to increase synthesis and release of prostaglandins, and that antipyretics bring down the fever because they inhibit the increased synthesis.

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“…It is not certain whether any prostaglandin is present in the cat brain stem, but PGF2O has been extracted from cat fore-brain (Horton & Main, 1966) and from bovine brain (Samuelsson, 1964) and a prostaglandin-like material has been extracted from cat cerebral and cerebellar cortex (Coceani & Wolfe, 1965). A mixture of prostaglandins (tentatively identified as E. and F2,) is released from the somatosensory cortex following transcallosal stimulation and stimulation of the contralateral superficial radial nerve (Shaw & Ramwell, personal communication; see also Shaw, 1964, andRamwell, 1965).…”

Section: Discussionmentioning

confidence: 99%