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SUMMARY1. Experiments, using electrophysiological recording techniques, were carried out to confirm the report that prostaglandins affect spinal reflexes in cats.2. Ventral root potentials evoked by stimulation of the ipsilateral dorsal root were recorded. Those with a latent period corresponding to a monosynaptic pathway were used primarily in this investigation. 6. It is concluded that prostaglandins, two of which have previously been identified in cat brain extracts, have pronounced and long-lasting effects on monosynaptic spinal reflexes.

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