Identification of plant-derived genetically modified organisms in food and feed using a hydrogel oligonucleotide microchip

Gryadunov, Dmitry; Getman, Irina A.; Chizhova, S. I.; Mikhailovich, Vladimir; Заседателев, А. С.; Romanov, Georgy A.

doi:10.1134/s0026893311050062

Cited by 1 publication

(1 citation statement)

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“…Additionally, many rapid biosensing methods have been developed, such as isothermal-amplification-based biosensors [ 174 ], portable immune biosensors [ 175 ], and functional nucleic-acids-based biosensors [ 176 ]. Gryadunov et al [ 177 ] designed a DNA hydrogel chip for the detection of transgenic crops. The method is based on the hybridization of amplified DNA and oligonucleotide probes on the chip, trigger the change in fluorescence intensity, and realizes the detection of four GM foods.…”

Section: Stimulus-responsive Dna Hydrogel Biosensors For Food Safety ...mentioning

confidence: 99%

Stimulus-Responsive DNA Hydrogel Biosensors for Food Safety Detection

Wang

Lai

et al. 2023

Biosensors

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Food safety has always been a major global challenge to human health and the effective detection of harmful substances in food can reduce the risk to human health. However, the food industry has been plagued by a lack of effective and sensitive safety monitoring methods due to the tension between the cost and effectiveness of monitoring. DNA-based hydrogels combine the advantages of biocompatibility, programmability, the molecular recognition of DNA molecules, and the hydrophilicity of hydrogels, making them a hotspot in the research field of new nanomaterials. The stimulus response property greatly broadens the function and application range of DNA hydrogel. In recent years, DNA hydrogels based on stimulus-responsive mechanisms have been widely applied in the field of biosensing for the detection of a variety of target substances, including various food contaminants. In this review, we describe the recent advances in the preparation of stimuli-responsive DNA hydrogels, highlighting the progress of its application in food safety detection. Finally, we also discuss the challenges and future application of stimulus-responsive DNA hydrogels.

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