Identification of phytochemicals as potential therapeutic agents that binds to Nsp15 protein target of coronavirus (SARS-CoV-2) that are capable of inhibiting virus replication

Kumar, Suresh; Kashyap, Priya; Chowdhury, Suman; Kumar, Sunny; Panwar, Anil; Kumar, Ashok

doi:10.1016/j.phymed.2020.153317

Cited by 98 publications

(71 citation statements)

References 21 publications

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“…The study reported that ajmalicine, alpha terpinyl acetate, curcumin, gingerol, novobiocin, piperine, rosmarinic acid, silymarin, and aranotin, sarsasapogenin, and ursonic acid exhibited binding with the Nsp15 protein. Therefore, these phytochemicals might effectively inhibit viral replication and their efficacy should be evaluated in pre-clinical as well as clinical studies [ 182 ]. Another study conducted molecular docking simulations between functional foods and SARS-CoV-2 Mpro.…”

Section: Available Repurposed Drugs Against Covid-19mentioning

confidence: 99%

COVID-19, cytokines, inflammation, and spices: How are they related?

et al. 2021

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Background Cytokine storm is the exaggerated immune response often observed in viral infections. It is also intimately linked with the progression of COVID-19 disease as well as associated complications and mortality. Therefore, targeting the cytokine storm might help in reducing COVID-19-associated health complications. The number of COVID-associated deaths (as of January 15, 2021; https://www.worldometers.info/coronavirus/ ) in the USA is high (1199/million) as compared to countries like India is low (110/million). Although the reason behind this is not clear, spices may have some role in explaining this difference. Spices and herbs are used in different traditional medicines, especially in countries such as India to treat various chronic diseases due to their potent antioxidant and anti-inflammatory properties. Aim To evaluate the literature available on the anti-inflammatory properties of some spices which might prove beneficial in the prevention and treatment of COVID-19 associated cytokine storm. Method A detailed literature search has been conducted on PubMed for collecting information pertaining to the COVID-19; the history, origin, key structural features, and mechanism of infection of SARS-CoV-2; the repurposed drugs in use for the management of COVID-19 and the anti-inflammatory role of spices to combat COVID-19 associated cytokine storm. Key findings The literature search resulted in numerous in vitro , in vivo and clinical trials that have reported the potency of spices to exert anti-inflammatory effects by regulating crucial molecular targets for inflammation. Significance As spices are derived from Mother Nature and are inexpensive, they are relatively safer to consume. Therefore, their anti-inflammatory property can be exploited to combat the cytokine storm in COVID-19 patients. This review thus focuses on the current knowledge on the role of spices for the treatment of COVID-19 through suppression of inflammation-linked cytokine storm.

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Section: Available Repurposed Drugs Against Covid-19mentioning

confidence: 99%

COVID-19, cytokines, inflammation, and spices: How are they related?

et al. 2021

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“…Curcumin has already been demonstrated to inhibit SARS-CoV-1 replication (EC 50 of >10 µM), the coronavirus which caused the 2003 epidemic [66]. Additionally, several molecular docking studies have been performed that suggest curcumin would be effective at inhibiting SARS-CoV-2 replication [67], through interacting with the spike glycoprotein and inhibiting angiotensin-converting enzyme 2 (ACE2) [68], inhibiting the viral non-structural protein Nsp15 [69], or inhibiting the main viral protease [70].…”

Section: Severe Acute Respiratory Syndrome Coronavirusmentioning

confidence: 99%

Curcumin as an Antiviral Agent

Jennings

Parks

2020

Viruses

138

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“…There was an attempt to design a theoretical model of a carbon nanotube-UNA drug matrix to block the entry of human immunodeficiency virus (HIV) [86]. Moreover, a recent document demonstrated that UNA has the potential to strongly interact with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Nsp15, an endoribonuclease which is essential for the lifecycle of coronaviruses [87,88]. Molecular docking and dynamics analyses show that UNA is predicted to bind stably with the catalytic residues of SARS-CoV-2 Nsp15 via hydrogen bonds, suggesting that UNA may represent one of drug candidates to inhibit replication of SARS-CoV-2, the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic.…”

Section: Antiviral Effectsmentioning

confidence: 99%

Therapeutic Potential of Ursonic Acid: Comparison with Ursolic Acid

Son

Lee

2020

Biomolecules

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Plants have been used as drugs to treat human disease for centuries. Ursonic acid (UNA) is a naturally occurring pentacyclic triterpenoid extracted from certain medicinal herbs such as Ziziphus jujuba. Since the pharmacological effects and associated mechanisms of UNA are not well-known, in this work, we attempt to introduce the therapeutic potential of UNA with a comparison to ursolic acid (ULA), a well-known secondary metabolite, for beneficial effects. UNA has a keto group at the C-3 position, which may provide a critical difference for the varied biological activities between UNA and ULA. Several studies previously showed that UNA exerts pharmaceutical effects similar to, or stronger than, ULA, with UNA significantly decreasing the survival and proliferation of various types of cancer cells. UNA has potential to exert inhibitory effects in parasitic protozoa that cause several tropical diseases. UNA also exerts other potential effects, including antihyperglycemic, anti-inflammatory, antiviral, and antioxidant activities. Of note, a recent study highlighted the suppressive potential of UNA against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Molecular modifications of UNA may enhance bioavailability, which is crucial for in vivo and clinical studies. In conclusion, UNA has promising potential to be developed in anticancer and antiprotozoan pharmaceuticals. In-depth investigations may increase the possibility of UNA being developed as a novel reagent for chemotherapy.

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Identification of phytochemicals as potential therapeutic agents that binds to Nsp15 protein target of coronavirus (SARS-CoV-2) that are capable of inhibiting virus replication

Cited by 98 publications

References 21 publications

COVID-19, cytokines, inflammation, and spices: How are they related?

COVID-19, cytokines, inflammation, and spices: How are they related?

Curcumin as an Antiviral Agent

Therapeutic Potential of Ursonic Acid: Comparison with Ursolic Acid

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