Curcumin as an Antiviral Agent

Jennings, Morgan R.; Parks, Robin J.

doi:10.3390/v12111242

Cited by 139 publications

(112 citation statements)

References 81 publications

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“…An in vivo study on a mouse model with intravaginal HSV-2 showed significant protection against HSV-2 infection due to curcumin administration [ 74 ]. Curcumin exerts its antiviral effects through signaling pathways, such as actin filament organization by replication inhibition in dengue virus and viral hemorrhagic septicemia virus; anti-inflammation and antioxidation activity inhibiting HIV replication; conformation of viral/cellular surface proteins through viral attachment in Zika virus, chikungunya virus, vesicular stomatitis virus, and human respiratory syncytial virus; HSC71 expression induces viral entry block in viral hemorrhagic septicemia virus; NF-κB signaling induce inhibition the replication and viral egress in Influenza A virus and HSV-2 [ 75 ]. We found nine surveys showing curcumin activity against SARS-CoV-2 targets.…”

Section: Discussionmentioning

confidence: 99%

Compounds of plants with activity against SARS-CoV-2 targets

Marmitt

Goettert

Rempel³

2021

Expert Review of Clinical Pharmacology

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Introduction The COVID-19 global pandemic is a public health emergency due to its high virulence and mortality. Many vaccine development studies at clinical trials are currently conducted to combat SARS-CoV-2. Plants are a rich source of phytochemicals with different biological activities, including antiviral activities, which are the focus of many studies. Areas covered This review shows compounds of traditional plants listed on RENISUS list have therapeutic properties against SARS-CoV-2 targets. Expert Opinion The rise of new variants, more pathogenic and virulent, impacts in the increase of mortality from SARS-CoV-2 infection, and thus, the control of the outbreaks of disease remains a global challenge. Other’s drug and vaccines development is an essential element in controlling SARS-COV-2. Therefore, it is imperative that approach to tackle this pandemic has to be solidly evidence-informed. It should be noticed that the immune system does play critical roles in fighting viruses. Studies show that T cells levels decreased continuously as the disease progressed. T cell-mediated cellular immune response, probably by immunological memory, is essential for direct virus eradication after infection whilst B cells functions in producing antibodies that neutralize virus.But, have distinct patterns of T cell response exist in different patients, suggesting the possibility of distinct clinical approaches. Efforts are concentrated to elucidate the underlying immunological mechanisms in SARS-CoV-2 pathogenesis and progression for better design of diagnostic, therapeutic and preventive strategies. We seek to identify biomolecules with the potential to act in biomarkers that predict how severe the disease can get. But it is important to warn that the plants that produce the compounds mentioned here should not be used without a physician prescription. Finally, we speculate that these compounds may eventually attract the attention of physicians and researchers to perform tests in specific contexts of SARS-CoV-2 infection, and if they show positive results, be tested in Clinical trials.

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Section: Discussionmentioning

confidence: 99%

Compounds of plants with activity against SARS-CoV-2 targets

Marmitt

Goettert

Rempel³

2021

Expert Review of Clinical Pharmacology

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“…The ethnopharmacology study of Zingiberaceae plants collected in Central Sulawesi, found the application of Curcuma longa to treat the HIV-1 infection. Literature investigation found that Curcuma longa contained curcumin as major compound that has been reported to possess a wide range inhibition of viruses such as dengue virus, herpes virus, and human immunodeficiency virus [ 7 , 17 ]. Therefore, we interest in further testing the other Zingiberaceae plants for antiviral activity.…”

Section: Discussionmentioning

confidence: 99%

Antiviral screening on Alpinia eremochlamys, Etlingera flexuosa, and Etlingera acanthoides extracts against HIV-infected MT-4 cells

Zubair

Khairunisa

Widodo

et al. 2021

Heliyon

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Alpinia eremochlamys K. Schum , Etlingera flexuosa A.D. Poulsen, and Etlingera acanthoides A.D. Poulsen are endemic Zingiberaceae plants from Central Sulawesi, Indonesia. This study is the first report on screening the potential antiviral activity of ethanol extracts of the leaves, pseudostems, and rhizomes parts on HIV-infected MT-4 cells and identifying chemical constituents by GC-MS. The plants were extracted by the maceration method using 96% ethanol as a solvent. The antiviral activity was measured using Viral-ToxGlo colorimetric method and using the extracts at concentrations ranging from 7.8 to 1000 μg/mL. GC-MS was used to identify the secondary metabolites of potential extracts. The results showed that ethanol extract of E. acanthoides rhizome was the most potent antiviral activity (IC 50 of 1.74 ± 2.46 μg/mL) and less toxic on lymphocyte (MT-4) cells (CC 50 of 204.90 ± 106.35 μg/mL), affording the highest value of selectivity index (SI) of 117.76. A. eremochlamys rhizomes also showed promising antiviral activity with IC 50 of 64.18 ± 2.58 μg/mL and no toxicity on MT-4 cells affording a high SI value 19.05. Preliminary GC-MS identification showed the presence of terpenoids and fatty acids as major compounds. Zerumbone, ar-turmerone, caryophyllene, and caryophyllene oxide were also detected. Chemical constituents identified by GC-MS might be responsible for the antiviral activity of extracts, suggesting further isolation and antiviral testing of the purified compounds.

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“…Accordingly, curcumin has presented effectiveness against a wide number of viruses, such as the Human Immunodeficiency Virus (HIV), Hepatitis C Virus (HCV), Human Cytomegalovirus (HCMV), Epstein-Barr Virus (EBV), Bovine Herpesvirus 1 (BHV 1), Chikungunya Virus, Ebola Virus, Enterovirus 71 (EV71), Rift Valley Fever Virus (RVFV), Human Norovirus (HuNoV), Respiratory Syncytial Virus (RSV), Fish Viral Hemorrhagic Septicemia Virus (VHSV), and Influenza A Virus (IAV) [23] .…”

Section: Curcumin As An Antiviral Alternative Against Sars-cov-2mentioning

confidence: 99%

Will curcumin nanosystems be the next promising antiviral alternatives in COVID-19 treatment trials?

Dourado

Freire

Pereira

et al. 2021

Biomedicine & Pharmacotherapy

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The COVID-19 has become of striking interest since the number of deaths is constantly rising all over the globe, and the search for an efficient treatment is more urgent. In light of this worrisome scenario, this opinion review aimed to discuss the current knowledge about the potential role of curcumin and its nanostructured systems on the SARS-CoV-2 targets. From this perspective, this work demonstrated that curcumin urges as a potential antiviral key for the treatment of SARS-CoV-2 based on its relation to the infection pathways. Moreover, the use of curcumin-loaded nanocarriers for increasing its bioavailability and therapeutic efficiency was highlighted. Additionally, the potential of the nanostructured systems by themselves and their synergic action with curcumin on molecular targets for viral infections have been explored. Finally, a viewpoint of the studies that need to be carried out to implant curcumin as a treatment for COVID-19 was addressed.

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Curcumin as an Antiviral Agent

Cited by 139 publications

References 81 publications

Compounds of plants with activity against SARS-CoV-2 targets

Compounds of plants with activity against SARS-CoV-2 targets

Antiviral screening on Alpinia eremochlamys, Etlingera flexuosa, and Etlingera acanthoides extracts against HIV-infected MT-4 cells

Will curcumin nanosystems be the next promising antiviral alternatives in COVID-19 treatment trials?

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