Identification of oxytocin and vasopressin in the testis and in adrenal tissue

Hd, Nicholson; Rw, Swann; Gd, Burford; Wathes, D C; Dg, Porter; Bt, Pickering

doi:10.1016/0167-0115(84)90169-1

Cited by 155 publications

(67 citation statements)

References 19 publications

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“…Conversely, ACTH-positive cells in macronodular hyperplasias express Leydig cell markers, suggesting that their neuroendocrine characteristics could be regarded as a feature of gonadal-like differentiation (105). This hypothesis is also supported by the observation that AVP and 5-HT are physiologically present in the human testis (111,249,250,251).…”

Section: Pathophysiological Significance Of Paracrine Factor Expressisupporting

confidence: 67%

MECHANISMS IN ENDOCRINOLOGY: Autocrine/paracrine regulatory mechanisms in adrenocortical neoplasms responsible for primary adrenal hypercorticism

Lefebvre

Prévost

Louiset

2013

European Journal of Endocrinology

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A wide variety of autocrine/paracrine bioactive signals are able to modulate corticosteroid secretion in the human adrenal gland. These regulatory factors, released in the vicinity of adrenocortical cells by diverse cell types comprising chromaffin cells, nerve terminals, cells of the immune system, endothelial cells, and adipocytes, include neuropeptides, biogenic amines, and cytokines. A growing body of evidence now suggests that paracrine mechanisms may also play an important role in the physiopathology of adrenocortical hyperplasias and tumors responsible for primary adrenal steroid excess. These intra-adrenal regulatory systems, although globally involving the same actors as those observed in the normal gland, display alterations at different levels, which reinforce the capacity of paracrine factors to stimulate the activity of adrenocortical cells. The main modifications in the adrenal local control systems reported by now include hyperplasia of cells producing the paracrine factors and abnormal expression of the latter and their receptors. Because steroid-secreting adrenal neoplasms are independent of the classical endocrine regulatory factors angiotensin II and ACTH, which are respectively suppressed by hyperaldosteronism and hypercortisolism, these lesions have long been considered as autonomous tissues. However, the presence of stimulatory substances within the neoplastic tissues suggests that steroid hypersecretion is driven by autocrine/paracrine loops that should be regarded as promising targets for pharmacological treatments of primary adrenal disorders. This new potential therapeutic approach may constitute an alternative to surgical removal of the lesions that is classically recommended in order to cure steroid excess.European Journal of Endocrinology 169 R115-R138

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Section: Pathophysiological Significance Of Paracrine Factor Expressisupporting

confidence: 67%

MECHANISMS IN ENDOCRINOLOGY: Autocrine/paracrine regulatory mechanisms in adrenocortical neoplasms responsible for primary adrenal hypercorticism

Lefebvre

Prévost

Louiset

2013

European Journal of Endocrinology

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“…In addition, stress-induced central release of oxytocin can ameliorate stress-associated symptoms, such as anxiety. [26] Synthesis of oxytocin in the male reproductive system was first revealed by Nicholson et al in 1984. [27] Oxytocin is present at higher concentrations in the prostate than in the plasma and can increase the resting tone of prostatic tissue.…”

Section: Discussionmentioning

confidence: 99%

“…[26] Synthesis of oxytocin in the male reproductive system was first revealed by Nicholson et al in 1984. [27] Oxytocin is present at higher concentrations in the prostate than in the plasma and can increase the resting tone of prostatic tissue. Oxytocin is involved in prostate contraction and in the resulting expulsion of prostatic secretions at ejaculation.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin in The Prevention of Injury Due to Testicular Torsion/Detorsion in Rats

Fırat¹,

Erdemır²,

Kölükçü³

et al. 2017

Ulus Travma Acil Cerrahi Derg

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“…Les capillaires ne sont les seuls moyens de transport puisque la sécrétion d'ocytocine dans le LCR a été parfaitement démontrée (HELLER, 1969, ROBINSON et ZIMMERMAN, 1973) [18,20].…”

Section: Figure4unclassified

L’ocytocine : données nouvelles et perspectives

Constantin¹

1992

bavf

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L’extrait post-hypophysaire a été introduit dans la Pharmacopée au début du siècle, l’indication principale était le traitement des insuffisances de la contraction utérine. Peu à peu, on a compris qu’il y avait deux hormones peptidiques dans l’extrait : l’ocytocine (1953) et la vasopressine (1964). La notion de neuro-sécrétion est apparue en même temps (1956). Des neurophysines spécifiques sont couplées à ces deux hormones. On a également analysé les hormones hypothalamiques dans toute la série animale, et constaté qu’elles étaient de bons marqueurs des étapes de la phylogénèse. L’hypothalamus n’a pas l’exclusivité de la synthèse de l’ocytocine, des cellules lutéales (granulosa) en font de même, mais en quantité beaucoup plus faibles. Enfin, des recherches sur le rat ont permis de mettre en évidence une action négative sur la mémorisation et une action positive sur le comportement maternel.

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Identification of oxytocin and vasopressin in the testis and in adrenal tissue

Cited by 155 publications

References 19 publications

MECHANISMS IN ENDOCRINOLOGY: Autocrine/paracrine regulatory mechanisms in adrenocortical neoplasms responsible for primary adrenal hypercorticism

MECHANISMS IN ENDOCRINOLOGY: Autocrine/paracrine regulatory mechanisms in adrenocortical neoplasms responsible for primary adrenal hypercorticism

Oxytocin in The Prevention of Injury Due to Testicular Torsion/Detorsion in Rats

L’ocytocine : données nouvelles et perspectives

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