Identification of Novel Tumor-Microenvironment-Regulating Factor That Facilitates Tumor Immune Infiltration in Colon Cancer

Wang, Ying; Wang, Yu; Xu, C.; Liu, Yuhang; Huang, Zhaohui

doi:10.1016/j.omtn.2020.08.029

Cited by 17 publications

(12 citation statements)

References 25 publications

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“…Immune microenvironment was implicated to play an important role in cancer progression ( Quail and Joyce, 2017 ; Zhang et al, 2020a ; Zhang et al, 2020b ; Wang et al, 2020 ). CD74 was the receptor of MIF and the CD74-MIF signaling pathway regulated the activity of macrophages and other immune cells ( Borghese and Clanchy, 2011 ; Figueiredo et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

CD74 Correlated With Malignancies and Immune Microenvironment in Gliomas

Tang

et al. 2021

Front. Mol. Biosci.

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Background: Cluster of differentiation 74 (CD74) is found to be highly involved in the development of various types of cancers and could affect the activities of infiltrated cells in the tumor microenvironment. However, these studies only focus on a few types of immune cells. Our study aims to comprehensively explore the role of CD74 in glioma prognosis and immune microenvironment.Methods: A total of 40 glioma specimens were collected in this study. We extracted data from The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and Gene-Expression Omnibus (GEO) databases to explore the expression pattern of CD74 in gliomas. gene sets enrichment analysis and gene set variation analysis analyses were conducted to characterize the immune features of CD74. ESTIMATE, ssGSEA, Tumor IMmune Estimation Resource, and CIBERSORT algorithms were applied to assess the immune infiltration. Kaplan-Meier analysis was used for survival analysis. Receiver operating characteristic analysis was used to evaluate the predictive accuracy of CD74 in glioma diagnosis and prognosis.Results: A total of 2,399 glioma patients were included in our study. CD74 was highly expressed in glioma tissue compared to normal brain tissue and its expression was significantly higher in the high-grade glioma compared to the lower grade glioma at transcriptional and translational levels. Besides, CD74 was positively associated with immune checkpoints and inflammatory cytokines as well as immune processes including cytokine secretion and leukocyte activation. The high expression of CD74 indicated a high infiltration of immune cells such as macrophages, dendritic cells, and neutrophils. Moreover, patients with high expression of CD74 had poor prognoses. CD74 had moderate predictive accuracy in the diagnosis of glioblastoma and prediction of survival.Conclusions: In conclusion, our study revealed that the high expression of CD74 was associated with poor prognosis and high immune infiltration. CD74 could be used as a potential target for glioma treatment and as a biomarker to predict the prognosis of glioma patients.

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Section: Discussionmentioning

confidence: 99%

CD74 Correlated With Malignancies and Immune Microenvironment in Gliomas

Tang

et al. 2021

Front. Mol. Biosci.

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“…Stromal and immune infiltration in the TME plays an important role in the progression of solid tumors. Higher ESTIMATE scores have been correlated with poor prognosis in multiple cancers, with higher scores associated with shorter overall survival in CRC patients [ 29 , 30 ]. Utilizing this algorithm with the TCGA CC and RC data, we calculated correlation coefficients between ESTIMATE scores and CSF3 ligand and receptor expression (all reported data has p-values < 0.0001).…”

Section: Resultsmentioning

confidence: 99%

Colony-stimulating factor 3 signaling in colon and rectal cancers: Immune response and CMS classification in TCGA data

et al. 2021

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Colorectal cancer is the 2nd leading cause of cancer-related deaths in the world. The mechanisms underlying CRC development, progression, and resistance to treatment are complex and not fully understood. The immune response in the tumor microenvironment has been shown to play a significant role in many cancers, including colorectal cancer. Colony-stimulating factor 3 (CSF3) has been associated with changes to the immune environment in colorectal cancer animal models. We hypothesized that CSF3 signaling would correlate with pro-tumor tumor microenvironment changes associated with immune infiltrate and response. We utilized publicly available datasets to guide future mechanistic studies of the role CSF3 and its receptor (CSF3R) play in colorectal cancer development and progression. Here, we use bioinformatics data and mRNA from patients with colon (n = 242) or rectal (n = 92) cancers, obtained from The Cancer Genome Atlas Firehose Legacy dataset. We examined correlations of CSF3 and CSF3R expression with patient demographics, tumor stage and consensus molecular subtype classification. Gene expression correlations, cell type enrichment, Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data scores and Gene Ontology were used to analyze expression of receptor and ligand, tumor microenvironment infiltration of immune cells, and alterations in biological pathways. We found that CSF3 and CSF3R expression is highest in consensus molecular subtype 1 and consensus molecular subtype 4. Ligand and receptor expression are also correlated with changes in T cell and macrophage signatures. CSF3R significantly correlates with a large number of genes that are associated with poor colorectal cancer prognosis.

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“…Tumor immune microenvironment has attracted more and more attention due to its crucial role in cancer progression ( Quail and Joyce, 2017 ; Wang et al, 2020 ; Zhang X. et al, 2020 ; Zhang Y. et al, 2020 ). Previous studies indicated that lncRNAs could affect tumor immune microenvironment and thus promote tumor progression ( Xu et al, 2019 ; Sun et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Bioinformatic Analyses Identify a Prognostic Autophagy-Related Long Non-coding RNA Signature Associated With Immune Microenvironment in Diffuse Gliomas

Tang

Liu

et al. 2021

Front. Cell Dev. Biol.

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BackgroundAutophagy and long non-coding RNA (lncRNA) play a critical role in tumor progression and microenvironment. However, the role of autophagy-related lncRNAs (ARLs) in glioma microenvironment remains unclear.MethodsA total of 988 diffuse glioma samples were extracted from TCGA and CGGA databases. Consensus clustering was applied to reveal different subgroups of diffuse gliomas. Kaplan-Meier analysis was used to evaluate survival differences between groups. The infiltration of immune cells was estimated by ssGSEA, TIMER, and CIBERSORT algorithms. The construction of ARL signature was conducted using principal component analysis.ResultsConsensus clustering revealed two clusters of diffuse gliomas, in which cluster 1 was associated with poor prognosis and enriched with malignant subtypes of gliomas. Moreover, cluster 1 exhibited high apoptotic and immune characteristics, and it had a low purity and high infiltration of several immune cells. The constructed ARL signature showed a promising accuracy in predicting the prognosis of glioma patients. ARL score was significantly elevated in the malignant subtype of glioma and the high ARL score indicated a poor prognosis. Besides, the high ARL score notably indicated low tumor purity and high infiltration of macrophages and neutrophils.ConclusionOur study developed and validated a novel ARL signature for the classification of diffuse glioma, which was closely associated with glioma immune microenvironment and could serve as a promising prognostic biomarker for glioma patients.

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Identification of Novel Tumor-Microenvironment-Regulating Factor That Facilitates Tumor Immune Infiltration in Colon Cancer

Cited by 17 publications

References 25 publications

CD74 Correlated With Malignancies and Immune Microenvironment in Gliomas

CD74 Correlated With Malignancies and Immune Microenvironment in Gliomas

Colony-stimulating factor 3 signaling in colon and rectal cancers: Immune response and CMS classification in TCGA data

Bioinformatic Analyses Identify a Prognostic Autophagy-Related Long Non-coding RNA Signature Associated With Immune Microenvironment in Diffuse Gliomas

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