Identification of Novel Fluorinated Surfactants in Aqueous Film Forming Foams and Commercial Surfactant Concentrates

D’Agostino, Lisa A.; Mabury, Scott A.

doi:10.1021/es403729e

Cited by 290 publications

(425 citation statements)

References 48 publications

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“…One serious glitch in the regulation of production and use of long-F-chain PFASs is that companies that did not adhere to the USEPA Stewardship Program immediately started or increased production of these PFASs in order to meet increasing market demands and Multiplication of components in a technical product [16][17][18] also complicates the regulators' task.…”

Section: The Need For and Compliance With Regulation Is Not Globalmentioning

confidence: 99%

Per- and polyfluorinated substances (PFASs): Environmental challenges

Krafft

Riess²

2015

Current Opinion in Colloid & Interface Science

215

122

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Section: The Need For and Compliance With Regulation Is Not Globalmentioning

confidence: 99%

Per- and polyfluorinated substances (PFASs): Environmental challenges

Krafft

Riess²

2015

Current Opinion in Colloid & Interface Science

215

122

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“…10−12 This has led to a phasing out of PFAAs with more than six perfluorinated carbons 13−15 and to a proliferation of possible replacement substances. 16,17 However, little is known about the inherent hazards or the environmental behavior of these replacement structures. Lack of chemical standards continues to impede monitoring and experimental investigation.…”

Section: ■ Introductionmentioning

confidence: 99%

Exploring the Use of Molecular Docking to Identify Bioaccumulative Perfluorinated Alkyl Acids (PFAAs)

Hungerbuehler

2015

Environ. Sci. Technol.

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Methods to predict the bioaccumulation potential of per- and polyfluorinated alkyl substances (PFAS) are sorely needed, given the proliferation of these substances and lack of data on their properties and behavior. Here, we test whether molecular docking, a technique where interactions between proteins and ligands are simulated to predict both bound conformation and interaction affinity, can be used to predict PFAS binding strength and biological half-life. We show that an easy-to-implement docking program, Autodock Vina, can successfully redock perfluorooctanesulfonate (PFOS) to human serum albumin with deviations smaller than 2 Å. Furthermore, predicted binding strengths largely fall within one standard deviation of measured values for perfluorinated alkyl acids (PFAAs). Correlations with half-lives suggest both membrane partitioning and protein interactions are important, and that serum albumin is only one of a number of proteins controlling the fate of these chemicals in organisms. However, few data are available for validation of our approach as a broad screening tool, and available data are highly variable. We therefore call for collection of new data, particularly including proteins other than serum albumin and substances beyond perfluorooctanoic acid (PFOA) and PFOS. The methods we discuss in this work can serve as a framework for guiding such data collection.

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“…Perfluoroalkyl substances are key components in this formulation because they lower the surface tension at the air-foam interface and form a film over the hydrocarbon fuel to prevent re-ignition [6][7][8]. The concentration and composition of PFASs in AFFF vary by year of production, fabrication process and by manufacturer [6,9]. AFFF have been widely used at sites such as airports, oil refineries and military bases for emergency and training purposes [6].…”

Section: Introductionmentioning

confidence: 99%