2006
DOI: 10.1016/j.bcmd.2006.07.003
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Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human β-globin gene cluster

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Cited by 21 publications
(35 citation statements)
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“…In another interesting study developed by Andrade et al, the pattern of gene expression was evaluated in reticulocytes of an individual with the deletional form of PHHF. In this study the authors also identified the up-regulation of chromatin remodeling proteins (ARID1B and TSPYL1 ) as also involved in the reactivation of  globin (de Andrade et al 2006).…”
Section: Molecular Biology and The Identification Of Targets To Treatmentioning
confidence: 98%
“…In another interesting study developed by Andrade et al, the pattern of gene expression was evaluated in reticulocytes of an individual with the deletional form of PHHF. In this study the authors also identified the up-regulation of chromatin remodeling proteins (ARID1B and TSPYL1 ) as also involved in the reactivation of  globin (de Andrade et al 2006).…”
Section: Molecular Biology and The Identification Of Targets To Treatmentioning
confidence: 98%
“…These conditions are characterized by large deletions to variable extents of the human b-like globin cluster, with decreased or absent b-globin chains and a compensatory variable increase of c-globin chains (Weatheral and Clegg 2001;Forget 1998). Some of the detectable transcripts may participate in globin gene regulation and RBC function and have had their altered mRNA expression confirmed by real-time PCR experiments, suggesting a novel, integrated model to explain the increased expression of c-globin in those conditions (De Andrade et al 2006). Herein, we investigate the expression of four new red cell-related genes in erythroid differentiation.…”
Section: Introductionmentioning
confidence: 94%
“…By the suppression subtractive hybridization method (Diatchenko et al 1996), we have previously identified genes differentially expressed in reticulocytes, morphologically identifiable cells, immediately prior to RBCs during erythroid differentiation, from subjects heterozygous for db-thalassemia and deletional hereditary persistence of fetal hemoglobin (HPFH) (De Andrade et al 2006). These conditions are characterized by large deletions to variable extents of the human b-like globin cluster, with decreased or absent b-globin chains and a compensatory variable increase of c-globin chains (Weatheral and Clegg 2001;Forget 1998).…”
Section: Introductionmentioning
confidence: 99%
“…Unlike other QTL, no candidate gene has been proposed in the region of chromosome 8q until recently. The gene encoding the zinc fingers and homeobox 2 (ZHX2) transcription factor located on 8q24 has emerged as a potential candidate gene for γ-globin regulation 7 . Deletion in β-globin cluster leads to unusually high levels of Hb F transcripts in reticulocytes, termed hereditary persistent of foetal haemoglobin.…”
Section: Introductionmentioning
confidence: 99%