Identification of Nine M6A-Related Long Noncoding RNAs as Prognostic Signatures Associated with Oxidative Stress in Oral Cancer Based on Data from The Cancer Genome Atlas

Li, Shan; Lu, Yu‐Chuan; Song, Yihua; Zhu, Xiaoli; Xiang, Chengcheng; Zuo, Er-Dong; Che, Xu

doi:10.1155/2022/9529814

Cited by 7 publications

(5 citation statements)

References 47 publications

(47 reference statements)

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“…Recent researches have shown that immune infiltration is associated with the initiation, progression, and metastasis in human cancers ( Stenstrom et al, 2021 ; Ren et al, 2022 ; Shan et al, 2022 ). Several algorithms, such as TIMER, EPIC, QUANTISEQ, XCELL, MCPCOUNTER, CIBERSORT, CIBERSORT-ABS, and TIDE, were applied to explore the correlation between LIPT1 expression and the infiltration of different immune cells in pan-cancer.…”

Section: Resultsmentioning

confidence: 99%

A pan-cancer analysis of copper homeostasis-related gene lipoyltransferase 1: Its potential biological functions and prognosis values

Liu

Luo²,

Yan³

et al. 2022

Front. Genet.

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As a key copper homeostasis-related molecule, lipoyltransferase 1 (LIPT1) is an essential enzyme for the activation of mitochondrial 2-ketoacid dehydrogenase, participating in fatty acylation. However, the biological significances of LIPT1 in the pan-cancer are unclear. Here, we comprehensively analyzed the functional characteristics of LIPT1 in human cancers and its roles in immune response. We found that LIPT1 was down-regulated in some cancers. And LIPT1 overexpression is associated with favorable prognosis in these patients, such as breast cancer, clear cell renal cell carcinoma, ovarian cancer and gastric cancer. We also explored the mutational status and methylation levels of LIPT1 in human cancers. Gene enrichment analysis indicated that abnormally expressed LIPT1 was significantly associated with immune cells infiltration, such as B cells, CD8+ T cells and cancer-associated fibroblast cells. The result from single cell sequencing reflected the important roles of LIPT1 in the regulation of several biological behaviors of cancer cells, such as DNA damage response and cell apoptosis. Taken together, our research could provide a comprehensive overview about the significances of LIPT1 in human pan-cancer progression, prognosis and immune.

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Section: Resultsmentioning

confidence: 99%

A pan-cancer analysis of copper homeostasis-related gene lipoyltransferase 1: Its potential biological functions and prognosis values

Liu

Luo²,

Yan³

et al. 2022

Front. Genet.

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show abstract

“…There is experimental evidence that activated naive B cells can inhibit tumor growth by promoting Th1 polarization 63 . In prostate cancer, naive B cells can prevent further development of tumor cells and contribute to a good prognosis for patients 64 . Plasma cells, the final functional state of the B cell lineage, are long-lived, non-proliferating, antibody-secreting cells 65 .…”

Section: Discussionmentioning

confidence: 99%

Angiogenesis-related lncRNAs index: A predictor for CESC prognosis, immunotherapy efficacy, and chemosensitivity

Huang,

Yi,

et al. 2024

J. Cancer

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Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) is a common gynecologic tumor and patients with advanced and recurrent disease usually have a poor clinical outcome. Angiogenesis is involved in the biological processes of tumors and can promote tumor growth and invasion. In this paper, we created a signature for predicting prognosis based on angiogenesis-related lncRNAs (ARLs). This provides a prospective direction for enhancing the efficacy of immunotherapy in CESC patients. We screened seven OS-related ARLs by univariate and multivariate regression analyses and Lasso analysis and developed a prognostic signature at the same time. Then, we performed an internal validation in the TCGA-CESC cohort to increase the precision of the study. In addition, we performed a series of analyses based on ARLs, including immune cell infiltration, immune function, immune checkpoint, tumor mutation load, and drug sensitivity analysis. Our created signature based on ARLs can effectively predict the prognosis of CESC patients. To strengthen the prediction accuracy of the signature, we built a nomogram by combining signature and clinical features.

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“…Some studies also described the role of m 6 A modification in regulating the redox balance of cells. For examples, several m 6 A-related lncRNAs are associated with oxidative stress in oral cancer and can predict the prognosis of oral squamous cell carcinoma [ 55 ]. The demethylase FTO promoted oxidative stress and apoptosis of ovarian cancer cells to inhibit tumour growth in nude mice [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

GPX8 deficiency–induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells

et al. 2023

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Glutathione peroxidase 8 (GPX8) is a key regulator of redox homoeostasis. Whether its antioxidant activity participates in the regulation of m 6 A modification is a crucial issue, which has important application value in cancer treatment. In this study, MeRIP-seq was used to explore the characteristics of transcriptome-wide m 6 A modification in GPX8-deficient oral cancer cells. Oxidative stress caused by the lack of GPX8 resulted in 1,279 hyper- and 2,287 hypo-methylated m 6 A peaks and 2,036 differentially expressed genes in GPX8-KO cells. Twenty-eight differentially expressed genes were related to the cell response to oxidative stress, and half of them changed their m 6 A modification. In GPX8-KO cells, m 6 A regulators IGF2BP2 and IGF2BP3 were upregulated, while FTO, RBM15, VIRMA, ZC3H13, and YTHDC2 were downregulated. After H 2 O 2 treatment, the expression changes of RBM15, IGF2BP2, and IGF2BP3 were further enhanced. These data indicated that GPX8-mediated redox homoeostasis regulated m 6 A modification, thereby affecting the expression and function of downstream genes. This study highlights the possible significance of GPX8 and the corresponding m 6 A regulatory or regulated genes as novel targets for antioxidant intervention in cancer therapy.

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Identification of Nine M6A-Related Long Noncoding RNAs as Prognostic Signatures Associated with Oxidative Stress in Oral Cancer Based on Data from The Cancer Genome Atlas

Cited by 7 publications

References 47 publications

A pan-cancer analysis of copper homeostasis-related gene lipoyltransferase 1: Its potential biological functions and prognosis values

A pan-cancer analysis of copper homeostasis-related gene lipoyltransferase 1: Its potential biological functions and prognosis values

Angiogenesis-related lncRNAs index: A predictor for CESC prognosis, immunotherapy efficacy, and chemosensitivity

GPX8 deficiency–induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells

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