A pan-cancer analysis of copper homeostasis-related gene lipoyltransferase 1: Its potential biological functions and prognosis values

Liu, Ying; Luo, Guopei; Yan, Yuanliang; Peng, Jinwu

doi:10.3389/fgene.2022.1038174

Cited by 13 publications

(9 citation statements)

References 40 publications

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“…Emerging research has revealed that cuproptosis participates in the development and treatment of cancers and that an imbalance of copper homeostasis leads to cancer cell growth and migration [26] . In our research, we observed that most CRGs were differentially expressed between CRC and normal tissues.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of Cuproptosis-related Genes in Prognosis and Tumor Microenvironment Infiltration in Colorectal Cancer

Chen

Liu

et al. 2023

Preprint

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Colorectal cancer (CRC) is a common malignancy, with high incidence and mortality rates. Cuproptosis, a novel form of copper-induced programmed cell death, contributes to tumor progression. Whether cuproptosis-related genes (CRGs) play a role in CRC remains unclear. Here, we systematically assessed CRG mutations in CRC. Seven of the 10 CRGs exhibited significant differential expression between CRC and normal tissues. CDKN2Aand DLAT were identified as independent risk factors for predicting overall survival (OS) in CRC using univariate and multivariate Cox analyses, and a risk score model was constructed based on CDKN2A and DLAT. Patients with CRC were categorized into high- and low-risk groups based on their median risk scores. Patients with CRC in the low-risk group had longer OS than those in the high-risk group. Receiver operating characteristic curve analysis indicated that the risk score model had good predictive accuracy for OS. Spearman’s analysis showed that CDKN2A and DLAT expressions were significantly associated with immune cell infiltration in CRC. Our research revealed CRGs’ prognostic value, particularly CDKN2A and DLAT, in CRC and demonstrated the relationship between CDKN2A/DLAT and immune infiltration in CRC, thereby contributing to the outcome evaluation of patients with CRC and identifying novel targets for CRC immunotherapy.

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Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of Cuproptosis-related Genes in Prognosis and Tumor Microenvironment Infiltration in Colorectal Cancer

Chen

Liu

et al. 2023

Preprint

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“…Emerging research has revealed that cuproptosis participates in the development and treatment of cancers and that an imbalance of copper homeostasis leads to cancer cell growth and migration [27] . In our research, we observed that most CRGs were differentially expressed between CRC and normal tissues.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of Cuproptosis-related Genes in Prognosis and Tumor Microenvironment Infiltration in Colorectal Cancer

Chen

Liu

et al. 2023

Preprint

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Colorectal cancer (CRC) is a common malignancy, with high incidence and mortality rates. Cuproptosis, a novel form of copper-induced programmed cell death, contributes to tumor progression. Whether cuproptosis-related genes (CRGs) play a role in CRC remains unclear. Here, we systematically assessed CRG mutations in CRC. Seven of the 10 CRGs exhibited significant differential expression between CRC and normal tissues. CDKN2A and DLAT were identified as independent risk factors for predicting overall survival (OS) in CRC using univariate and multivariate Cox analyses, and a risk score model was constructed based on CDKN2A and DLAT. Patients with CRC were categorized into high- and low-risk groups based on their median risk scores. Patients with CRC in the low-risk group had longer OS than those in the high-risk group. Receiver operating characteristic curve analysis indicated that the risk score model had good predictive accuracy for OS. Spearman’s analysis showed that CDKN2A and DLAT expressions were significantly associated with immune cell infiltration and immune checkpoints in CRC. Our research revealed CRGs’ prognostic value, particularly CDKN2A and DLAT, in CRC and demonstrated the relationship between CDKN2A/DLAT and immune infiltration in CRC, thereby contributing to the outcome evaluation of patients with CRC and identifying novel targets for CRC immunotherapy.

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“…The overexpression of LIPT-1 was associated with a favorable prognosis in patients with breast cancer, and it was also correlated with immune cell infiltration (B lymphocytes, fibroblasts, and CD8+ T lymphocytes) [128]. A role for LIPT-1 as a novel prognostic and immunologic biomarker in breast cancer has been proposed [128]. An analysis of the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) 2000 dataset showed that patients with breast cancer with a high expression of the CRG SLC31A1 had a worse prognosis than those with a low expression of this CRG [130].…”

Section: Coppermentioning

confidence: 98%

“…The role of CRG LIPT1 in carcinogenesis was established in a 2022 study by Liu et al [128]. This gene encodes LIPT1, a lipoic acid-specific sequence enzyme responsible for maintaining the oxidative and reductive metabolism of glutamine [129].…”

Section: Coppermentioning

confidence: 99%

“…This gene encodes LIPT1, a lipoic acid-specific sequence enzyme responsible for maintaining the oxidative and reductive metabolism of glutamine [129]. The overexpression of LIPT-1 was associated with a favorable prognosis in patients with breast cancer, and it was also correlated with immune cell infiltration (B lymphocytes, fibroblasts, and CD8+ T lymphocytes) [128]. A role for LIPT-1 as a novel prognostic and immunologic biomarker in breast cancer has been proposed [128].…”

Section: Coppermentioning

confidence: 99%

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Micronutrient Status and Breast Cancer: A Narrative Review

Forma,

Grunwald,

Zembala

et al. 2024

IJMS

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Breast cancer is one of the most common cancers worldwide, at the same time being one of the most prevalent causes of women’s death. Many factors such as alcohol, weight fluctuations, or hormonal replacement therapy can potentially contribute to breast cancer development and progression. Another important factor in breast cancer onset includes micronutrient status. In this narrative review, we analyzed 23 micronutrients and their possible influence on breast cancer onset and progression. Further, the aim of this study was to investigate the impact of micronutrient status on the prevention of breast cancer and its possible influence on various therapeutic pathways. We researched meta-analyses, systemic and narrative reviews, retrospective studies, as well as original studies on human and animal models. The results of these studies indicate a possible correlation between the different levels of micronutrients and a decreased risk of breast cancer as well as a better survival rate. However, further studies are necessary to establish adequate doses of supplementation of the chosen micronutrients and the exact mechanisms of micronutrient impact on breast cancer therapy.

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A pan-cancer analysis of copper homeostasis-related gene lipoyltransferase 1: Its potential biological functions and prognosis values

Cited by 13 publications

References 40 publications

Comprehensive Analysis of Cuproptosis-related Genes in Prognosis and Tumor Microenvironment Infiltration in Colorectal Cancer

Comprehensive Analysis of Cuproptosis-related Genes in Prognosis and Tumor Microenvironment Infiltration in Colorectal Cancer

Comprehensive Analysis of Cuproptosis-related Genes in Prognosis and Tumor Microenvironment Infiltration in Colorectal Cancer

Micronutrient Status and Breast Cancer: A Narrative Review

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