Identification of new potent inhibitor of aldose reductase from Ocimum basilicum

Bhatti, Huma Aslam; Tehseen, Yildiz; Maryam, Kiran; Uroos, Maliha; Siddiqui, Bina Shaheen; Hameed, Abdul; Iqbal, Jamshed

doi:10.1016/j.bioorg.2017.08.011

Cited by 20 publications

(8 citation statements)

References 33 publications

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“…7 Thus, it has been used in the treatment of several diseases, such as cough, headache, kidney dysfunction, acne treatment, abdominal pain, inflammation, diabetes, and eye diseases, owing to its stimu-lating, anti-spasmodic, carminative, and digestive actions, and antifungal, insecticidal, and antibacterial activities. 9 Regarding the application of this species in the phytopharmaceutical sector, no studies are available in the literature; in contrast, there are some studies about O. basilicum coloured varieties and cultivars. 2,8 Concerning the red rubin basil (O. basilicum var.…”

Section: Introductionmentioning

confidence: 99%

Ocimum basilicum var. purpurascens leaves (red rubin basil): a source of bioactive compounds and natural pigments for the food industry

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Ocimum basilicum var. purpurascens leaves (red rubin basil): a source of bioactive compounds and natural pigments for the food industry

et al. 2019

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“…Basilicumin inhibited AKR1A1 at IC 50 value of 0.78 µM and 2.1 µM for AKR1B1 activity. It was suggested that coumarin and glucose scaffold in basilicumin moiety enhance the activity [ 64 ].…”

Section: Resultsmentioning

confidence: 99%

Cataract Preventive Role of Isolated Phytoconstituents: Findings from a Decade of Research

Lim

Schneider

et al. 2018

Nutrients

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Cataract is an eye disease with clouding of the eye lens leading to disrupted vision, which often develops slowly and causes blurriness of the eyesight. Although the restoration of the vision in people with cataract is conducted through surgery, the costs and risks remain an issue. Botanical drugs have been evaluated for their potential efficacies in reducing cataract formation decades ago and major active phytoconstituents were isolated from the plant extracts. The aim of this review is to find effective phytoconstituents in cataract treatments in vitro, ex vivo, and in vivo. A literature search was synthesized from the databases of Pubmed, Science Direct, Google Scholar, Web of Science, and Scopus using different combinations of keywords. Selection of all manuscripts were based on inclusion and exclusion criteria together with analysis of publication year, plant species, isolated phytoconstituents, and evaluated cataract activities. Scientists have focused their attention not only for anti-cataract activity in vitro, but also in ex vivo and in vivo from the review of active phytoconstituents in medicinal plants. In our present review, we identified 58 active phytoconstituents with strong anti-cataract effects at in vitro and ex vivo with lack of in vivo studies. Considering the benefits of anti-cataract activities require critical evaluation, more in vivo and clinical trials need to be conducted to increase our understanding on the possible mechanisms of action and the therapeutic effects.

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“…These compounds were evaluated in vitro against AR and aldehyde reductase activities. The results showed that C1 has a better and significant inhibitory activity on AR and aldehyde reductase with IC 50 values of 2.095 and 0.783 µM, respectively, followed by C2 (4.324 and 4.388 µM, respectively) [90]. Active compounds extracted from O. basilicum could be used in preventing cataract formation.…”

Section: Ocimum Basilicum (Lamiaceae)mentioning

confidence: 96%

Natural aldose reductase inhibitors for treatment and prevention of diabetic cataract: A review

2022

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Summary Introduction: Aldose reductase (AR) is an enzyme that catalyzes the reduction of glucose to sorbitol responsible for the development of diabetic complications like cataracts. Medicinal plants contain several phytocompounds that can inhibit this enzyme. Objective: The purpose of this review is to cite medicinal plants that have been tested for their ability to inhibit aldose reductase and consequently prevent cataracts and classify the major isolated compounds that have this activity. Methods: We reviewed 154 articles published between 1954 and 2020 in English via three databases: ScienceDirect, Web of Science, and PubMed. We have classified the plants that showed a significant anti-cataract effect, in the form of a list including the scientific and family names of each plant. Also, we have cited the IC50 values and the active constituents of each plant that showed inhibitory activity towards AR. Results: We have described 38 herbs belonging to 29 families. Besides, 47 isolated compounds obtained from the cited herbs have shown an AR inhibitory effect: luteolin, luteolin-7-O-β-D-glucopyranoside, apigenin, 3,5-di-O-caffeoyl-epi-quinic acid, delphinidin 3-O-β-galactopyranoside-3’-O-β-glucopyranoside, 3,5-di-O-caffeoylquinic acid methyl ester, andrographolide, 1,2,3,6-tetra-O-galloyl-β-D-glucose, 1,2,4,6-tetra-O-galloyl-β-D-glucose, 7-(3-hydroxypropyl)-3-methyl-8-β-O-D-glucoside-2H-chromen-2-one, E-4-(60-hydroxyhex-30-en-1-yl)phenyl propionate, delphinidin 3-O-β-galactopyranoside-3’,5’-di-O-β-glucopyranoside, 1,2,3-tri-O-galloyl-β-D-glucose, 1,2,3,4,6-penta-O-galloyl-β-D-glucose, 1,2,6-tri-O-galloyl-β-D-glucose, 2-(4-hydroxy-3-methoxyphenyl)ethanol, (4-hydroxy-3-methoxyphenyl)methanol, trans-anethole, gallic acid 4-O-β-D-(6’-O-galloyl)-glucoside, β-glucogallin, puerariafuran, quercetin, gallic acid 4-O-β-D-glucoside, 2,5-dihydroxybenzoic acid, 4-(4-hydroxy-3-methoxyphenyl)-2-butanone, protocatechuic acid, trans-cinnamic acid, gallic acid, p-coumaric acid and syringic acid. Conclusion: natural therapy becomes an interesting alternative in the treatment and prevention of cataract by using medicinal plants rich in active compounds considered as AR inhibitors.

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Identification of new potent inhibitor of aldose reductase from Ocimum basilicum

Cited by 20 publications

References 33 publications

Ocimum basilicum var. purpurascens leaves (red rubin basil): a source of bioactive compounds and natural pigments for the food industry

Ocimum basilicum var. purpurascens leaves (red rubin basil): a source of bioactive compounds and natural pigments for the food industry

Cataract Preventive Role of Isolated Phytoconstituents: Findings from a Decade of Research

Natural aldose reductase inhibitors for treatment and prevention of diabetic cataract: A review

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