“…The MAV-1 virion is structurally similar to that of human adenoviruses (Wigand et al, 1977), and its genomic organization is also similar to that of human adenovirus (Meissner et al, 1997). With the exception of the early region 3 (E3) gene (Beard et al, 1990), MAV-1 gene products have sequence similarity to those of human adenoviruses (Ball et al, 1988(Ball et al, , 1989(Ball et al, , 1991Beard et al, 1990;Cauthen and Spindler, 1996;Kring et al, 1992;Kring and Spindler, 1990). Of particular interest, given the potential association between the human adenovirus early region 1A (E1A) gene and long-term sequelae of infection such as COPD (Elliott et al, 1995;Matsuse et al, 1992), MAV-1 E1A has approximately 40% similarity to human adenovirus E1A, with the strongest similarity in conserved region 2 (CR2) (Ball et al, 1988).…”