Acute respiratory infection with mouse adenovirus type 1

Weinberg, Jason B.; Stempfle, Gregory S.; Wilkinson, John E.; Younger, John G.; Spindler, Katherine R.

doi:10.1016/j.virol.2005.06.021

Cited by 42 publications

(56 citation statements)

References 91 publications

(110 reference statements)

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“…Consistent with our previous reports (40,41), patchy areas of cellular inflammation developed in the lungs of infected adult mice beginning by 7 dpi (Fig. 4A, right columns).…”

Section: Mav-1 Viral Loads In Lungs Of Neonates and Adultssupporting

confidence: 92%

“…Acute MAV-1 infection induces the expression of multiple cytokines and chemokines in the lungs of adult mice (40,41). To determine whether virus-induced cytokine production differs between neonates and adults, we measured protein and mRNA levels of representative Th1 (IFN-␥) and Th2 (IL-4) cytokines along with those of chemokines (CCL5 and CXCL1) that are typically induced in the lung by acute MAV-1 respiratory infection.…”

Section: Mav-1 Viral Loads In Lungs Of Neonates and Adultsmentioning

confidence: 99%

“…Because mice are not fully permissive hosts for human adenovirus replication (14,18), it is difficult to study human adenovirus pathogenesis in vivo. We have established mouse adenovirus type 1 (MAV-1, also known as MAdV-1) as a useful model to study the pathogenesis of adenovirus respiratory infection in the natural host of the virus (5,40,41).…”

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confidence: 99%

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Susceptibility to Acute Mouse Adenovirus Type 1 Respiratory Infection and Establishment of Protective Immunity in Neonatal Mice

Procario

Levine

McCarthy

et al. 2012

J Virol

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There is an incomplete understanding of the differences between neonatal immune responses that contribute to the increased susceptibility of neonates to some viral infections. We tested the hypothesis that neonates are more susceptible than adults to mouse adenovirus type 1 (MAV-1) respiratory infection and are impaired in the ability to generate a protective immune response against a second infection. Following intranasal infection, lung viral loads were greater in neonates than in adults during the acute phase but the virus was cleared from the lungs of neonates as efficiently as it was from adult lungs. Lung gamma interferon (IFN-␥) responses were blunted and delayed in neonates, and lung viral loads were higher in adult IFN-␥ ؊/؊ mice than in IFN-␥ ؉/؉ controls. However, administration of recombinant IFN-␥ to neonates had no effect on lung viral loads. Recruitment of inflammatory cells to the airways was impaired in neonates. CD4 and CD8 T cell responses were similar in the lungs of neonates and adults, although a transient increase in regulatory T cells occurred only in the lungs of infected neonates. Infection of neonates led to protection against reinfection later in life that was associated with increased effector memory CD8 T cells in the lungs. We conclude that neonates are more susceptible than adults to acute MAV-1 respiratory infection but are capable of generating protective immune responses.

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“…Consistent with our previous reports (40,41), patchy areas of cellular inflammation developed in the lungs of infected adult mice beginning by 7 dpi (Fig. 4A, right columns).…”

Section: Mav-1 Viral Loads In Lungs Of Neonates and Adultssupporting

confidence: 92%

Section: Mav-1 Viral Loads In Lungs Of Neonates and Adultsmentioning

confidence: 99%

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Susceptibility to Acute Mouse Adenovirus Type 1 Respiratory Infection and Establishment of Protective Immunity in Neonatal Mice

Procario

Levine

McCarthy

et al. 2012

J Virol

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“…MAV-1 causes a widely disseminated infection in mice, targeting endothelial cells and cells of the monocyte lineage (13,21,28,31) and, after intranasal inoculation, respiratory epithelial cells (61). Defining the factors involved in the tropism of MAV-1 will include identifying the receptors used by the virus.…”

Section: Discussionmentioning

confidence: 99%

Usage of Integrin and Heparan Sulfate as Receptors for Mouse Adenovirus Type 1

Raman

Hsu

Ashley

et al. 2009

J Virol

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“…mouse adenovirus 1 (MAV-1) infection of C57BL/6 and BALB/c mice as a model to study the pathogenesis of adenovirus respiratory infection (19). One previous report demonstrated that intraperitoneal (i.p.)…”

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confidence: 99%

Proinflammatory Effects of Interferon Gamma in Mouse Adenovirus 1 Myocarditis

McCarthy

Procario

Twisselmann

et al. 2015

J Virol

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Adenoviruses are frequent causes of pediatric myocarditis. Little is known about the pathogenesis of adenovirus myocarditis, and the species specificity of human adenoviruses has limited the development of animal models, which is a significant barrier to strategies for prevention or treatment. We have developed a mouse model of myocarditis following mouse adenovirus 1 (MAV-1) infection to study the pathogenic mechanisms of this important cause of pediatric myocarditis. Following intranasal infection of neonatal C57BL/6 mice, we detected viral replication and induction of interferon gamma (IFN-␥) in the hearts of infected mice. MAV-1 caused myocyte necrosis and induced substantial cellular inflammation that was composed predominantly of CD3 ؉ T lymphocytes. Depletion of IFN-␥ during acute infection reduced cardiac inflammation in MAV-1-infected mice without affecting viral replication. We observed decreased contractility during acute infection of neonatal mice, and persistent viral infection in the heart was associated with cardiac remodeling and hypertrophy in adulthood. IFN-␥ is a proinflammatory mediator during adenovirus-induced myocarditis, and persistent adenovirus infection may contribute to ongoing cardiac dysfunction. IMPORTANCEStudying the pathogenesis of myocarditis caused by different viruses is essential in order to characterize both virus-specific and generalized factors that contribute to disease. Very little is known about the pathogenesis of adenovirus myocarditis, which is a significant impediment to the development of treatment or prevention strategies. We used MAV-1 to establish a mouse model of human adenovirus myocarditis, providing the means to study host and pathogen factors contributing to adenovirus-induced cardiac disease during acute and persistent infection. The MAV-1 model will enable fundamental studies of viral myocarditis, including IFN-␥ modulation as a therapeutic strategy.

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Acute respiratory infection with mouse adenovirus type 1

Cited by 42 publications

References 91 publications

Susceptibility to Acute Mouse Adenovirus Type 1 Respiratory Infection and Establishment of Protective Immunity in Neonatal Mice

Susceptibility to Acute Mouse Adenovirus Type 1 Respiratory Infection and Establishment of Protective Immunity in Neonatal Mice

Usage of Integrin and Heparan Sulfate as Receptors for Mouse Adenovirus Type 1

Proinflammatory Effects of Interferon Gamma in Mouse Adenovirus 1 Myocarditis

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