Identification of miRNAs and their targets involved in the secondary metabolic pathways of Mentha spp.

Singh, Nidhi; Srivastava, Swati; Shasany, Ajit Kumar; Sharma, Ashok

doi:10.1016/j.compbiolchem.2016.06.004

Cited by 62 publications

(34 citation statements)

References 66 publications

(73 reference statements)

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“…This is in agreement with the previous findings in which these families (miR5021, and miR5658) were found as highly populated, with a large number of predicted targets . The involvement of miR5021 family miRNAs has been shown in diverse biological processes related to growth and development, e.g., stress responses, signal transduction, transport, cell division, trichome development, essential oil, and many other metabolic pathways . The members from miR5658 family have been reported to be involved in regulating starch and sugar metabolism, and stress responses .…”

Section: Discussionsupporting

confidence: 91%

“…A good percentage of GC content (> 40%) in the miRNA sequences further specified their stability . When examined terpene biosynthesis, the miRNA families, miR2108, miR4993, miR396, miR5015, and miR414, targeting terpene pathway genes were more or less in agreement with the previous findings on terpene biosynthesis occurring in different plant species, Mentha spp., Z. officinale , Coffea , W. somnifera and Viscum album L. . As far as tartaric acid biosynthesis is concerned, this study, for the first time, detected miRNAs, belonging to 11 miR families, which could be associated with the post‐transcriptional or translational regulation of this pathway.…”

Section: Discussionmentioning

confidence: 83%

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Long noncoding RNAs and miRNAs regulating terpene and tartaric acid biosynthesis in rose‐scented geranium

2019

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This study aimed to explore the noncoding RNAs, which have emerged as key regulatory molecules in biological processes, in rose‐scented geranium. We analyzed RNA‐seq data revealing 26 784 long noncoding RNAs (lncRNAs) and 871 miRNAs in rose‐scented geranium. A total of 466 lncRNAs were annotated using different plant lncRNA public databases. Furthermore, 372 lncRNAs and 99 miRNAs were detected that target terpene and tartarate biosynthetic pathways. An interactome, comprising of lncRNAs, miRNAs, and mRNAs, was constructed that represents a noncoding RNA regulatory network of the target mRNAs. Real‐time quantitative PCR expression validation was done for selected lncRNAs involved in the regulation of terpene and tartaric acid pathways. This study provides the first insights into the regulatory functioning of noncoding RNAs in rose‐scented geranium.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 83%

Long noncoding RNAs and miRNAs regulating terpene and tartaric acid biosynthesis in rose‐scented geranium

2019

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“…Most recently, bioinformatics approaches have been utilized to mine miRNAs involved in terpenoid metabolism in Mentha spp . (Singh et al, 2016a), Ginger (Singh et al, 2016b), C. roseus (Pani and Mahapatra, 2013), and P. hexandrum (Biswas et al, 2016; Table 1). …”

Section: Role Of Mirnas In Terpenoid Biosynthesismentioning

confidence: 99%

Contemporary Understanding of miRNA-Based Regulation of Secondary Metabolites Biosynthesis in Plants

et al. 2017

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Plant's secondary metabolites such as flavonoids, terpenoids, and alkaloids etc. are known for their role in the defense against various insects-pests of plants and for medicinal benefits in human. Due to the immense biological importance of these phytochemicals, understanding the regulation of their biosynthetic pathway is crucial. In the recent past, advancement in the molecular technologies has enabled us to better understand the proteins, enzymes, genes, etc. involved in the biosynthetic pathway of the secondary metabolites. miRNAs are magical, tiny, non-coding ribonucleotides that function as critical regulators of gene expression in eukaryotes. Despite the accumulated knowledge of the miRNA-mediated regulation of several processes, the involvement of miRNAs in regulating secondary plant product biosynthesis is still poorly understood. Here, we summarize the recent progress made in the area of identification and characterizations of miRNAs involved in regulating the biosynthesis of secondary metabolites in plants and discuss the future perspectives for designing the viable strategies for their targeted manipulation.

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“…A computational approach in Mentha spp., revealed that miR156, miR414, and miR5021 are essential for regulation of essential oil biosynthesis. miR156 participates in flavone, flavonol biosynthesis, and terpenoid backbone biosynthesis [38].…”

Section: Alkaloidsmentioning

confidence: 99%

“…miRNA156-targeted squamosa promoter binding protein-like (SPL) intervenes in the temporal space regulation of sesquiterpene biosynthesis [44]. miR5021 is also involved in terpenoid backbone biosynthesis and miR414 is related to sesquiterpenoid and triterpenoid biosynthesis [38].…”

Section: Terpenoidsmentioning

confidence: 99%

MicroRNAs Associated with Secondary Metabolites Production

Vargas-Hernández¹,

Vázquez-Marrufo²,

Agustín³

et al. 2019

Plant Physiological Aspects of Phenolic Compounds

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MicroRNAs (miRNAs) are noncoding RNAs that play an important role in the regulation of the genetic expression in animals and plants by targeting mRNAs for cleavage or translational repression. Several miRNAs regulate the plant development, the metabolism, and the responses to biotic and abiotic stresses. Characterization of an miRNA has helped to show its role in fine tuning the mechanisms of posttranscriptional gene regulation. Although there is a lot of information related to miRNA regulation of some processes, the role of miRNA involved in the regulation of biosynthesis of secondary plant product is still poorly understood. In this chapter, we summarize the identification and characterization of miRNAs that participate in the regulation of the biosynthesis of secondary metabolites in plants and their use in the strategies to manipulate a controlled manipulation.

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Identification of miRNAs and their targets involved in the secondary metabolic pathways of Mentha spp.

Cited by 62 publications

References 66 publications

Long noncoding RNAs and miRNAs regulating terpene and tartaric acid biosynthesis in rose‐scented geranium

Long noncoding RNAs and miRNAs regulating terpene and tartaric acid biosynthesis in rose‐scented geranium

Contemporary Understanding of miRNA-Based Regulation of Secondary Metabolites Biosynthesis in Plants

MicroRNAs Associated with Secondary Metabolites Production

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