2015
DOI: 10.1371/journal.pntd.0003680
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Identification of microRNA Genes in Three Opisthorchiids

Abstract: Background Opisthorchis felineus, O. viverrini, and Clonorchis sinensis (family Opisthorchiidae) are parasitic flatworms that pose a serious threat to humans in some countries and cause opisthorchiasis/clonorchiasis. Chronic disease may lead to a risk of carcinogenesis in the biliary ducts. MicroRNAs (miRNAs) are small noncoding RNAs that control gene expression at post-transcriptional level and are implicated in the regulation of various cellular processes during the parasite- host interplay. However, to date… Show more

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Cited by 25 publications
(13 citation statements)
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“…Xu et al identified and cloned 6 new and 62 512 conserved adult C. sinensis miRNAs which are grouped into 284 families [ 97 ]. In another study, 33 novel and 18 conserved miRNAs were identified in C. sinensis (adult worms), including csi-miR-36b, which was not found by Xu et al [ 97 , 98 ]. The miRNAs of C. sinensis were concentrated along three branches of the phylogenetic tree leading to bilaterians, insects and coelomates.…”
Section: Reviewmentioning
confidence: 87%
“…Xu et al identified and cloned 6 new and 62 512 conserved adult C. sinensis miRNAs which are grouped into 284 families [ 97 ]. In another study, 33 novel and 18 conserved miRNAs were identified in C. sinensis (adult worms), including csi-miR-36b, which was not found by Xu et al [ 97 , 98 ]. The miRNAs of C. sinensis were concentrated along three branches of the phylogenetic tree leading to bilaterians, insects and coelomates.…”
Section: Reviewmentioning
confidence: 87%
“…Altogether, in total, 1 billion small RNAseq reads of sixteen published miRNA NGS datasets for all 3 opisthorchiids [11, 12], the references genomes for O. viverrini [14], C. sinensis [15] and the draft assembly of O. felineus (Ershov et al in prep) were used. For RNAseq data we used annotations and expression levels directly from Pomanznoy et al [5].…”
Section: Figurementioning
confidence: 99%
“…miRNAs are small non-coding RNAs that are post-transcriptional gene regulators with important roles in many biological processes [10]. Previously, miRNA complements of the 3 opisthorchiids were published and they showed a surprisingly variable number of miRNA genes (between 16 and 18 conserved and between 20 and 43 novel genes) that was unexpected [11,12]. The number of identified genes was also very low given the predictions from studies on miRNA evolution in flatworms [13] but most importantly no abundantly expressed miRNA was identified that showed sequential differences in all 3 species.…”
mentioning
confidence: 99%
“…Altogether, in total, billion small RNAseq reads of sixteen published miRNA NGS datasets for all 3 opisthorchiids [11,12], the references genomes for O. viverrini [14], C. sinensis [15] and the draft assembly of O. felineus (Ershov et al in prep) were used. For RNAseq data we used annotations and expression levels directly from Pomanznoy et al [5].…”
mentioning
confidence: 99%
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