Identification of Microbial Biofilms in Osteonecrosis of the Jaws Secondary to Bisphosphonate Therapy

Sedghizadeh, Parish P.; Kumar, Satish; Gorur, Amita; Schaudinn, Christoph; Shuler, Charles F.; Costerton, J. William

doi:10.1016/j.joms.2007.11.035

Cited by 197 publications

(156 citation statements)

References 23 publications

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“…[31,32] Histological studies have shown that microbial infection may be effective in the Figure 1. Clinical appearance of extraction sites: control group; complete mucosal healing, Group I; osteonecrosis with swelling and hyperaemia, Group II; osteonecrosis, Group III; complete mucosal healing.…”

Section: Resultsmentioning

confidence: 99%

Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

Duygu

Sapmaz-Metin

Kütan

et al. 2016

Biotechnology & Biotechnological Equipment

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The aim of this study is to investigate the effect of doxycycline collagen sponge on bisphosphonate-related osteonecrosis of the jaw (BRONJ) and the level of serum biomarkers as an indicator of osteonecrosis. Twenty-four rats were divided into four groups. Animals in the control group were injected with saline and animals in Groups I, II and III were injected with zoledronate three times a week for eight weeks. After eight weeks, the following procedures were performed in each group. In Group I: extraction of maxillary first molar, in Group II: extraction of maxillary first molar and mucoperiosteal coverage was performed and in Group III: extraction of maxillary first molar and mucoperiosteal coverage with doxycycline collagen sponges was performed. At the end of 16 weeks, all animals were sacrificed. Serum collagen type I C-telopeptide (CTx), tartrate-resistant acid phosphatase (TRACP 5b) and alkaline phosphatase (ALP) levels' analysis, clinical examination, histological and histomorphometrical analysis were performed. As a result no significant difference in CTx, TRACP 5b and ALP levels was observed between groups. Complete mucosal healing was observed in all animals in the control group and 66.7% of animals in Group III. The necrotic bone area in Group III was significantly lower than the other groups (p < 0.01). Statistically significant difference was observed between groups in terms of detached osteoclast number (p < 0.01). In conclusion, local application of doxycycline could have a positive effect in reducing the risk of BRONJ in rats.

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Section: Resultsmentioning

confidence: 99%

Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

Duygu

Sapmaz-Metin

Kütan

et al. 2016

Biotechnology & Biotechnological Equipment

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“…All of them are sensitive to penicillin, which is, thus, the drug of choice for the non-surgical treatment of ONJ. [12] The major goal of prevention for patients at risk for BRONJ or of treatment for those who have BRONJ is to preserve their quality of life, controlling pain and infections, and avoiding the development of new necrotic areas. [5] The risk is associated with the accumulation of drug doses during years of treatment.…”

Section: Diagnosismentioning

confidence: 99%

Bisphosphonate Induced Osteonecrosis of the Jaw

Tiwari¹,

Masih²,

Srivastava³

et al. 2018

AIMDR

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Osteonecrosis of the jaw is an important but uncommon side effect of bisphosphonate therapy. It may result in disabling and sometimes disfiguring complications that may affect the quality of life of patients. It occurs more frequently in patients on intravenous nitrogen-containing forms of bisphosphonates and is thought to be time and dose dependent. Currently, there is no recognized effective treatment apart from controlling pain and accompanied infection. Prevention of this complication is therefore important. In this article, some of the key issues of bisphosphonate-associated osteonecrosis of jaw are being reviewed.

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“…Antibiotics (amoxicillin 500 mg with clavulanic acid 125 mg, metronidazole 500 mg, and ciprofloxacin 500 mg) should be administered only in cases of BRONJ lesion exacerbation. Antibiograms are not applicable for determining correct BRONJ treatment as the bacterial flora found during microbiological culture correspond in the vast majority of cases to the habitual pathogenic buccal flora: Phorphyromonas gingivalis and Actinomyces actinomycetemcomitans (14). Antibiotic prophylaxis is therapeutically meaningless as BRONJ do not pose a threat for bacterial endocarditis, except when the patient is reached by the American Heart Association protocols for presurgical prescription.…”

Section: Clinical Care Protocol For Bronjmentioning

confidence: 99%

Clinical Healthcare Protocol for Bisphosphonate Related Osteonecrosis of the Jaw

Noemi¹

2017

IJDOH

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Identification of Microbial Biofilms in Osteonecrosis of the Jaws Secondary to Bisphosphonate Therapy

Cited by 197 publications

References 23 publications

Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

Bisphosphonate Induced Osteonecrosis of the Jaw

Clinical Healthcare Protocol for Bisphosphonate Related Osteonecrosis of the Jaw

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