Identification of Major Antioxidant Compounds from the Edible Mushroom Basidiomycetes-X (Echigoshirayukidake)

Sakamoto, Toshio; Li, Zhenshi; Nishida, Ayaka; Kadokawa, Asako; Yoshida, Takayuki; Wada, Naoki; Matsugo, Seiichi; Nakamura, Yutaka; Sato, Shigeo; Konishi, Tetsuya

doi:10.31083/j.fbe1402010

Cited by 3 publications

(7 citation statements)

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“…Functional studies of BDM-X are currently progressing and have unveiled several physiological and pharmacological functions such as being anti-oxidative, anti-obesity and diabetic, and offering liver damage protection including NASH, as reviewed elsewhere [27]. The search for a functional component is also simultaneously being developed [28,29].…”

Section: Basidiomycetes-x As a Mibyou-care Functional Food Resourcementioning

confidence: 99%

“…The metabolome data suggest that the major polyphenolics in BDM-X are flavonoids, and not simple phenolic compounds. Moreover, antioxidant compounds such as ergothioneine and vitamin E, which are another group of antioxidant components found in edible mushrooms [35], were also not found in BDM-X by metabolomics and subsequent selective isolation studies [28,29]. Although the flavonoids listed above were not detected as a major ingredient in BDM-X through the isolation study, this wide variety of flavonoid distribution is unique and will significantly contribute not only to the antioxidant potential of BDM-X, but also to other physiological functions, which are both already cleared or yet to be uncovered.…”

Section: Metabolome Analysis Of Bdm-xmentioning

confidence: 99%

“…A further analysis of the specific components which may play significant roles in the beneficial health functions of BDM-X was carried out by solvent extraction following HPLC and TLC. The major components with UV absorption and/or DPPH radical scavenging activity were targeted for isolation, and the structures of purified compounds were assigned using mass spectrometry (MS) and nuclear magnetic resonance (NMR) [28,29]. From these studies, three types of formyl pyrrole alkaloids (FPA), ergosterol, (10E,12Z)-octadeca-10,12-dienoic acid ((10E,12Z)-CLA), 2,3-dihydro-3,5dihydroxy-6-methyl-4H-pyran-4-one (DDMP), and two nucleosides, adenosine and uridine, were determined as the major ingredients existing at relatively high amounts and showing high or moderate DPPH radical scavenging activities in BDM-X.…”

Section: Selective Isolation and Quantification Of Major Ingredientsmentioning

confidence: 99%

Section: Selective Isolation and Quantification Of Major Ingredientsmentioning

confidence: 99%

“…1.6.2. DDMP DDMP was identified as a major component with strong DPPH radical scavenging activity in the aqueous extract of BDM-X [29]. It is also isolated from several resources other than fungi, such as lactobacterium [43] and onion [44], and reported to have several physiological functions, such as being anti-inflammatory, anti-mutagenic and having cancer cell toxicity and affecting autonomic neurons.…”

Section: Selective Isolation and Quantification Of Major Ingredientsmentioning

confidence: 99%

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Mushrooms as a Resource for Mibyou-Care Functional Food; The Role of Basidiomycetes-X (Shirayukidake) and Its Major Components

et al. 2022

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Mibyou has been defined in traditional oriental medicine as a certain physiological condition whereby an individual is not ill but not healthy; it is also often referred to as a sub-healthy condition. In a society focused on longevity, “Mibyou-care” becomes of primary importance for healthy lifespan expenditure. Functional foods can play crucial roles in Mibyou-care; thus, the search for novel resources of functional food is an important and attractive research field. Mushrooms are the target of such studies because of their wide variety of biological functions, such as immune modulation and anti-obesity and anticancer activities, in addition to their nutritional importance. Basidiomycetes-X (BDM-X; Shirayukidake in Japanese) is a mushroom which has several attractive beneficial health functions. A metabolome analysis revealed more than 470 components of both nutritional and functional interest in BDM-X. Further isolation and purification studies on its components using radical scavenging activity and UV absorbance identified ergosterol, (10E,12Z)-octadeca-10,12-dienoic acid (CLA), 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP), formyl pyrrole analogues (FPA), including 4-[2-foemyl-5-(hydroxymethyl)-1H-pyrrole-1-yl] butanamide (FPAII), adenosine and uridine as major components. Biological activities attributed to these components were related to the observed biological functions of BDM-X, which suggest that this novel mushroom is a useful resource for Mibyou-care functional foods and medicines.

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Section: Basidiomycetes-x As a Mibyou-care Functional Food Resourcementioning

confidence: 99%

Section: Metabolome Analysis Of Bdm-xmentioning

confidence: 99%

Section: Selective Isolation and Quantification Of Major Ingredientsmentioning

confidence: 99%

Section: Selective Isolation and Quantification Of Major Ingredientsmentioning

confidence: 99%

Section: Selective Isolation and Quantification Of Major Ingredientsmentioning

confidence: 99%

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Mushrooms as a Resource for Mibyou-Care Functional Food; The Role of Basidiomycetes-X (Shirayukidake) and Its Major Components

et al. 2022

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Anti‐inflammatory, Antioxidative, and Moisturizing Effects of Oxyceros horridus Lour. Ethanol Extract in Human Keratinocytes via the p38 Signaling Pathway

Sutopo,

Rahmawati,

Huang

et al. 2024

Chemistry & Biodiversity

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Skin is the largest and outermost organ in the human body; it serves as a vital defense mechanism against various external threats. Therefore, it is crucial to maintain its health through protection against harmful substances and adequate moisture levels. This study investigates the anti‐inflammatory, antioxidant, and moisturizing properties of Oxyceros horridus Lour. (Oh‐EE) in human keratinocytes. Oh‐EE demonstrates potent antioxidant activity and effectively protects against oxidative stress induced by external stimuli such as UVB radiation and H2O2. Additionally, it exhibits significant anti‐inflammatory effects proven by its ability to downregulate the expression of pro‐inflammatory cytokines, namely COX‐2 and IL‐6. The study also explores the involvement of the AP‐1 pathway, highlighting the ability of Oh‐EE to suppress the expression of p38 and its upstream regulator, MKK3/6, under UVB‐induced conditions. Interestingly, Oh‐EE can activate the AP‐1 pathway in the absence of external triggers. Furthermore, Oh‐EE enhances skin moisture by upregulating the expression of key genes involved in skin hydration, namely HAS3 and FLG. These findings underscore the potential of Oh‐EE as a versatile ingredient in skincare formulations, providing a range of skin benefits. Further research is warranted to comprehensively understand the underlying mechanisms through which Oh‐EE exerts its effects.

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Influence of Organic and Inorganic Compounds of Various Metals on the Synthesis of Polysaccharides by the Medicinal Mushroom Trametes versicolor

Mustafin,

Suleimenova,

Narmuratova

et al. 2023

Journal of AOAC International

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Background To date, basidiomycetes are considered as promising objects of biotechnology, due to a number of biologically active compounds, such as polysaccharides and triterpenes. These compounds have a high therapeutic potential and demonstrate immunomodulatory, antiviral, and antifungal activities. Objective The purpose of this study was to study the effect of various concentrations of metal citrates and sulphates on the content of exo- and endopolysaccharides of the fungus Trametes versicolor. Methods The mycelium was grown by deep cultivation on a semisyntheticglucose-peptone-yeast medium with different contents of zinc, copper, and manganese salts, after which the extraction and measurement of the concentration of polysaccharides were carried out. Results The results obtained showed that copper citrate at a concentration of 4 mg/l had the greatest positive effect on biomass yield. The intensity of biomass growth on a nutrient medium with copper citrate increased by 80%. Zinc citrate increased the content of exopolysaccharides by 29% compared to the medium without metal salts. When manganese citrate was added to the medium, the productivity of synthesis decreased, but an increase in the growth rate of mycelium biomass was observed. Sulphates of these metals led to a decrease in the productivity of exopolysaccharide synthesis by 12% for zinc and 35% for manganese. Conclusion The addition of both copper citrate and copper sulphate to the medium led to a decrease in the synthesis productivity by 66% and 24%, respectively. The introduction of both citrates and sulphates of these metals into the culture medium led to an increase in the percentage of endopolysaccharides in the mycelium of the fungus. Highlights Copper citrate enhances Trametes versicolor biomass by 80%. Zinc citrate increases exopolysaccharide content by 29%. Copper sulphate optimizes endopolysaccharide production.

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Identification of Major Antioxidant Compounds from the Edible Mushroom Basidiomycetes-X (Echigoshirayukidake)

Cited by 3 publications

References 0 publications

Mushrooms as a Resource for Mibyou-Care Functional Food; The Role of Basidiomycetes-X (Shirayukidake) and Its Major Components

Mushrooms as a Resource for Mibyou-Care Functional Food; The Role of Basidiomycetes-X (Shirayukidake) and Its Major Components

Anti‐inflammatory, Antioxidative, and Moisturizing Effects of Oxyceros horridus Lour. Ethanol Extract in Human Keratinocytes via the p38 Signaling Pathway

Influence of Organic and Inorganic Compounds of Various Metals on the Synthesis of Polysaccharides by the Medicinal Mushroom Trametes versicolor

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