“…Sugars, amino acids, phytohormones, and macromolecules such as RNA, proteins are transported from source to distant sink through the vascular system, in which system macromolecules upload from companion cells (CC) to sieve tube (SE) via plasmodesmata (PD; Notaguchi and Okamoto, 2015 ). Till now, cDNA library and omics profiling have been commendably established to identify a wide range of RNA signaling various plants species, such as cucumber ( Cucumis sativus L.) ( Zhang et al, 2016 ; Liu et al, 2020 ), pumpkin ( Cucurbit maxima ) ( Omid et al, 2007 ), Nicotiana benthamiana/ tomato ( Solanum lycopersicum ) ( Xia et al, 2018 ), Arabidopsis ( Arabidopsis thaliana ) ( Thieme et al, 2015 ), and grapes ( Vitis vinifera ) ( Yang et al, 2015 ). Evidence of biological studies in vivo have indicated that the regulatory function of RNAs (non-coding RNA and mRNA) were involving plant growth, defense, biological/economic yield, and certain morphological characteristics ( Banerjee et al, 2009 ; Huang and Yu, 2009 ).…”