“…With the recent acquisition of high-throughput phenotype and genotype data, it is now possible to directly identify pleiotropic causal mutations (Wagner and Zhang, 2011 ). The abundance of such high-throughput data in conjunction with a plethora of tools available for quantifying genotype-to-phenotype associations (Marchini et al, 2007 ; Purcell et al, 2007 ; Lipka et al, 2012 ; Zhou and Stephens, 2014 ) is providing increasing evidence for pleiotropic genes involved in evolution (Smith, 2016 ; Auge et al, 2019 ), disease resistance (Wisser et al, 2011 ; Lopez-Zuniga et al, 2019 ; Qiu et al, 2020 ), yield (Ward et al, 2019 ), and many other traits (Jiang et al, 2019 ; Rice et al, 2020 ). These analyses have also led to opposing views for (Boyle et al, 2017 ) and against (Wray et al, 2018 ) the ubiquitousness of pleiotropy in complex trait variation, particularly in the form of the omnigenic model.…”